Medicament composition for treating angina and application of medicament composition

A composition and technology for angina pectoris, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as sulfhydryl depletion, achieve the effects of enhancing curative effect, drug safety, and improving myocardial blood supply

Inactive Publication Date: 2014-03-12
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After 48-72 hours of continuous application of nitrates, drug resistance can be produced. The main mechanisms of drug resistance are depletion of sulfhydryl groups, inhibition of biotransformation of nitroglycerin or desensitization of guanylate cyclase, and sensitivity of blood vessels to vasoconstrictor active substances. However, there is still no theory that can fully explain the mechanism of nitrate resistance.

Method used

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  • Medicament composition for treating angina and application of medicament composition
  • Medicament composition for treating angina and application of medicament composition
  • Medicament composition for treating angina and application of medicament composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Crude drug prescription: 48 parts of peanut shells, 25 parts of burdock seeds, 12 parts of purslane, 25 parts of cassia seeds, 25 parts of corn silk, and 80 parts of mung beans.

[0016] Preparation method: Weigh and combine the above-mentioned medicinal materials, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 2 hours, add water for the second time to 8 times the weight of the medicinal materials, and decoct for 1.5 hours , combined decoction, concentrated under reduced pressure at 0.08MPa and 70°C to a relative density of 1.15 at 70°C, added 95% (v / v) ethanol to make the alcohol content reach 75% (v / v), stirred, and stood overnight , filtered, and the filtrate was concentrated under reduced pressure at 0.08MPa and 65°C to a relative density of 1.30 at 65°C, and was prepared into an oral liquid by adding water and sucrose.

Embodiment 2

[0018] Crude drug prescription: 50 parts of peanut shells, 20 parts of burdock seeds, 15 parts of purslane, 30 parts of cassia seeds, 18 parts of corn silk, and 70 parts of mung beans.

[0019] Preparation method: Weigh and combine the above-mentioned medicinal materials, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 2 hours, add water for the second time to 8 times the weight of the medicinal materials, and decoct for 1.5 hours , combined decoction, concentrated under reduced pressure at 0.08MPa and 70°C to a relative density of 1.15 at 70°C, added 95% (v / v) ethanol to make the alcohol content reach 85% (v / v), stirred, and stood overnight , filtered, and the filtrate was concentrated under reduced pressure at 0.08MPa and 65°C to a relative density of 1.30 at 65°C, and was prepared into an oral liquid by adding water and sucrose.

Embodiment 3

[0021] Crude drug prescription: 60 parts of peanut shells, 30 parts of burdock seeds, 10 parts of purslane, 20 parts of cassia seeds, 28 parts of corn silk, and 80 parts of mung beans.

[0022] Preparation method: Weigh and combine the above-mentioned medicinal materials, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 2 hours, add water for the second time to 8 times the weight of the medicinal materials, and decoct for 1.5 hours , combined decoction, concentrated under reduced pressure at 0.08MPa and 70°C until the relative density was 1.20 at 70°C, added 95% (v / v) ethanol to make the alcohol content reach 80% (v / v), stirred, and stood overnight , filtered, and the filtrate was concentrated under reduced pressure at 0.08MPa and 65°C to a relative density of 1.30 at 65°C, and was prepared into an oral liquid by adding water and sucrose.

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Abstract

The invention discloses a medicament composition for treating angina and an application of the medicament composition. The composition is prepared from the following traditional Chinese herbal medicines in parts by weight: 40-60 parts of peanut shells, 18-30 parts of burdock, 8-16 parts of portulaca oleracea, 18-30 parts of semen cassiae, 18-30 parts of corn stigma and 50-100 parts of mung bean. The medicament composition disclosed by the invention is definite in curative effect in treating angina, can improve myocardium blood supply, can prevent nitrate medicine resistance, and can improve the curative effect of nitrate on angina.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating angina pectoris and its application, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Angina pectoris refers to a group of syndromes with precordial pain as the main clinical manifestation caused by coronary artery insufficiency caused by coronary atherosclerotic stenosis, temporary myocardial ischemia and hypoxia. Nitrate drugs have been used in the treatment of cardiovascular diseases for more than 100 years. Their main pharmacological activity is to relax vascular smooth muscle, especially for venous blood vessels and large coronary artery branches, which lead to vasodilation. Reduce cardiac preload and postload, improve myocardial blood supply, reduce oxygen consumption, used for anti-myocardial ischemia, anti-angina pectoris, widely used for various types of coronary heart disease. The mechanism of action of nitrates to relax vascular...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P9/10
Inventor 潘巍巍玛黎清赵琛
Owner QINGDAO MUNICIPAL HOSPITAL
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