Leukocyte-depleted cell filter with multiple filtering units

A technology of filtering device and filtering unit, which is applied in the fields of blood filtering, drug devices, other medical devices, etc., to avoid the loss of platelets and sensitive coagulation factors, improve the effect, and improve the removal rate of white blood cells.

Active Publication Date: 2014-03-12
上海输血技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to study and design a flexible leukocyte-removing filter device with multiple filter units, which can realize integrated production with blood bags, integral high-pressure steam sterilization, and separation of required blood components such as platelets first. , and then for the purpose of leukocyte filtration; at the same time, the area of ​​a single filter unit is greatly reduced, which greatly alleviates the deformation during blood filtration, and also improves the blood recovery rate and reduces the waste of blood resources

Method used

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  • Leukocyte-depleted cell filter with multiple filtering units

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Effect test

Embodiment 1

[0032] see figure 1, the leukocyte-removing soft filter device of the present invention has a plurality of filter units, including a liquid inlet pipe 1, a flexible housing 2, a first liquid inlet chamber 3, a second liquid inlet chamber 4, filter elements 5 and 13, a partition 6, and a support tube 7. The first liquid outlet chamber 8, the second liquid outlet chamber 9, the liquid outlet pipe 10, the inner membrane 11 and the auxiliary membrane 12; the filter elements 5 and 1 are respectively connected to the upper and lower parts of the partition 6, and are made of non-woven fabric The shape of the filter elements 5 and 13 when they are integrated is similar to the shape of the flexible shell 2, and is melted and sealed in the flexible shell 2 after being pre-processed by the peripheral high-frequency or high-frequency method. The liquid inlet pipe 1, the first liquid inlet chamber 3, the filter element 5 and the first liquid outlet chamber 4 constitute the first filter uni...

Embodiment 2

[0049] Through experiments, the inventor sterilized the leukocyte-removing soft filter device with multiple filter units in Example 1 of the present invention at 115-121°C for 30 minutes by high-pressure steam, and there was no adhesion or deformation inside and outside the device after sterilization; Example 1 of the present invention The leukocyte-removing soft filter device with multiple filter units is sealed at one end, and the other end is fed with a gas with a pressure of 50 kPa higher than the atmospheric pressure, immersed in water at 20°C to 30°C for 2 minutes, and there is no leakage.

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Abstract

The invention provides a leukocyte-depleted cell filter with multiple filtering units. The filter is composed of a liquid inlet pipe (1), a flexible shell body (2), a first liquid inlet chamber (3), a first liquid outlet chamber (4), filter elements (5,13), a partition (6), a supporting pipe (7), a second liquid inlet chamber (8), a second liquid inlet chamber (9), a liquid outlet pipe (10), an inner film (11) and an auxiliary film (12). The liquid inlet pipe (1), the first liquid inlet chamber (3), the filter element (5) and the first liquid outlet chamber (4) compose the first filtering unit. The second liquid inlet chamber (8), the filtering element (13), the second liquid outlet chamber (9) and the liquid outlet pipe (10) compose the second filtering units. Totally, the two filtering units which are independent to each other are formed. Blood passes through the two filtering units, the leukocyte-depleting effect is greatly improved, and meanwhile the phenomena that the area of the single filtering unit is prevented from being excessively large, the utilization efficiency of filtering materials is not high and lateral leakage happens to the edge of the filter are avoided. By means of the leukocyte-depleted cell filter, non-leakage can be kept for two minutes under the 50Kpa compressed air. Under the temperature ranging from 115 DEG C to 121 DEG C, high-pressure steam sterilizing is carried out for half an hour. After sterilization, adhesion and deformation do not happen to the inside and the outside of the device and the large application value is achieved.

Description

technical field [0001] The invention relates to medical equipment, in particular to a blood filter device, in particular to a leukocyte-removing filter device with a plurality of filter units. Background technique [0002] Due to clinical needs, especially during surgery, blood transfusions are often given to patients. And when blood or blood components containing leukocytes are transfused, some adverse reactions can be caused. Such as non-hemolytic febrile reaction (FNHTR), HLA alloimmunization, transfusion-associated graft-versus-host disease (TA-GVHD), ineffective platelet transfusion, etc. At the same time, white blood cells are also carriers of leukotropic viruses, such as cytomegalovirus (MCV), human T-lymphoblastic leukemia virus (HTLV-I / II) and human immunodeficiency virus (HIV), and blood transfusion may also cause these viruses to spread through the blood and Activation of latent virus. After years of clinical verification, it has been proved that the filtration...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/34
CPCA61M1/3496A61M2205/75A61M2207/00
Inventor 李云
Owner 上海输血技术有限公司
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