Animal sleep deprivation device and application thereof

An animal sleep and animal cage technology, applied in animal taming devices, hypnosis devices, applications, etc., can solve the problems of animals unable to sleep, complex experimental devices, and large manual workload, achieve accurate and reliable experimental results, and improve experimental efficiency. , The effect of the overall structure is simple

Inactive Publication Date: 2014-03-12
TENTH PEOPLES HOSPITAL OF TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The obvious disadvantage of this device is that the animals are subjected to a series of stimuli such as isolation, braking, and immersion in water, and can only be used to deprive REM sleep; ground movement, making it impossible to fall asleep, the more representative ones are the horizontal turntable sleep deprivation method and the intermittent treadmill deprivation method
The disadvantage of this device is that the experimental device is complicated, and the animal is subject to a series of reactions caused by long-term exercise; 3) The drug model achieves the purpose of insomnia through drug administration, but the disadvantage is that the drug has obvious toxic and side effects, and the long-term drug administration has a large manual

Method used

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  • Animal sleep deprivation device and application thereof
  • Animal sleep deprivation device and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0048] Example 1 The animal sleep deprivation mechanical power device of the present invention

[0049] Please refer to figure 1 , figure 1 It is a schematic diagram of the structure of the animal sleep deprivation device of the present invention. The animal sleep deprivation device is provided with an animal cage 1, a stimulus pad 2 and a multi-lead program controller 3. The animal cage 1 is a rectangular parallelepiped cage. The stimulation generating pad 2 is placed in the animal cage 1. The stimulating backing plate 2 is sequentially provided with a sieve plate 21, a stimulating plate 22 and a supporting plate 23 from top to bottom. The sieve plate 21 is rectangular, and a plurality of sieve holes 211 are provided on the sieve plate 21. The sieve holes 211 are circular and arranged in an array. The stimulation plate 22 is also rectangular, and the upper surface is provided with a plurality of stimulation posts 221, and the stimulation posts 221 are also arranged in an arr...

Example Embodiment

[0052] Example 2 Method of using the animal sleep deprivation mechanical power device of the present invention

[0053] 1) According to the animal cage 1, select the matching stimulus backing plate 2, put the stimulating backing plate 2 into the animal cage 1, pass the wire 27 through the wire column 25 and then pass it out of the animal cage 1, connect the multi-lead program control 仪3;

[0054] 2) Connect the multi-lead program controller 3 to the power supply, observe the status of the indicator 33 to confirm that the wire 27 has been successfully connected, and then set the experimental parameters through the adjustment panel 34;

[0055] 3) Press the key 31 to start providing stimulation to the experimental animals, and determine the duration of the experiment according to the experimental plan.

[0056] In the experiment, one or more stimulus generation panels 2 can be connected according to actual needs.

Example Embodiment

[0057] Example 3 Exploring the parameter setting of SD rat sleep deprivation model

[0058] 1) Purchase a number of SD rats at 6-8 weeks, use Morris water maze to screen out animals with poor learning and memory abilities, and keep 12 of them. They were randomly divided into experimental group (stimulated group) and control group (non-stimulated group), each with 6 animals, and they were divided into 2 cages. Use standard large mouse group cage M-5 (size 475×350×200mm), choose a pallet size of 46.5×34×19cm for stimulation generation.

[0059] 2) Set the parameters of the multi-lead program controller: explore and adjust the stimulation amplitude 1-3cm, the stimulation / interval parameters such as 3s on / 12s off, 1min on / 4min off or 15min on / 60 min off, deprivation of sleep for 18 hours per day (16 per day) :00-10:00 of the next day), and then resume sleep for 6 hours (10:00-16:00 of the same day). Place the stimulus pad in the squirrel cage, turn on the power and then work, and f...

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Abstract

The invention relates to an animal sleep deprivation device and application of the animal sleep deprivation device. The animal sleep deprivation device is provided with a stimulation occurrence base plate and a multi-lead program control instrument. The stimulation occurrence base plate is sequentially provided with a sieve plate, a stimulation plate and a supporting plate from top to bottom. The sieve plate is provided with sieve holes. The upper end face of the stimulation plate is provided with stimulation columns which correspond to the sieve holes in position and can penetrate through the sieve holes. A mechanical power device is arranged between the stimulation plate and the supporting plate, and is connected with the multi-lead program control instrument through a guide line. The multi-lead program control instrument is provided with a switch key, a guide line interface and a parameter adjusting panel. When the animal sleep deprivation device is used for building an insomnic animal model, no harmful stimulation is produced on experimental animals, experimental results are more accurate and reliable, the repeatability is good, multiple insomnia models can be obtained, and operation is convenient. The animal sleep deprivation device is simple in structure and low in cost.

Description

technical field [0001] The invention relates to an animal experiment device, in particular to an animal sleep deprivation device and its application. Background technique [0002] Insomnia is a common clinical disease and problem that plagues modern people. According to reports, about 30% of adults in the world suffer from insomnia, and 20%-30% in my country, of which 1 / 3 is severe insomnia. Therefore, the research and prevention of insomnia is imminent. [0003] In biomedical research, we often rely on the use of animal models to verify experimental hypotheses and clinical hypotheses, in order to more effectively understand the occurrence and development of human diseases, and study prevention and treatment measures. Therefore, the use of animal models has become an extremely important experimental method and means in modern biomedical research, and rats and mice are currently the most commonly used experimental animals, accounting for more than 90% of experimental animals....

Claims

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Application Information

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IPC IPC(8): A61M21/00A01K15/02A01K67/027
Inventor 李双徐亚伟薛少博彭文辉李文嘉俞戈郭留杰徐大春
Owner TENTH PEOPLES HOSPITAL OF TONGJI UNIV
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