Tylosin in situ gel drug composition for livestock and preparation method thereof

A technology of in-situ gel and tylosin, which is applied in the direction of drug combination, antibacterial drugs, and pharmaceutical formulations, can solve problems such as difficulty in medication for piglets, reluctance of piglets to eat, and cumbersome injection operations.

Inactive Publication Date: 2014-04-09
佟丽 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to administer medicine to piglets. The operation of injection administration is cumbersome, time-consuming and low in efficiency, and the taste of the mixed feed is poor, and the piglets are unwilling to eat it, so the effect is poor.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1. Preparation of tylosin temperature-sensitive in-situ gel pharmaceutical composition

[0017] Take tylosin phosphate and add water to dissolve, add poloxamer 407 and poloxamer 188, add water to 50mL to fully swell into a uniform solution, add sodium bisulfite and disodium edetate, stir to dissolve, and finally phosphoric acid The concentrations of tylosin, poloxamer 407, poloxamer 188, sodium bisulfite and disodium edetate in the in situ gel were 20% (W / V) and 15% (W / V), respectively. V), 15% (W / V), 2% (W / V), 0.5% (W / V), divided into containers or spray devices for later use.

Embodiment 2

[0018] Example 2. Preparation of tylosin temperature / ion-sensitive in situ gel pharmaceutical composition

[0019] Take tylosin phosphate and add water to dissolve, add poloxamer 407, poloxamer 188, gellan gum, add water to 50mL to fully swell into a uniform solution, add sodium bisulfite and disodium edetate, Stir to dissolve, and finally the concentrations of tylosin phosphate, poloxamer 407, poloxamer 188, gellan gum, sodium bisulfite and disodium edetate in the in situ gel were 20% (W / V), 15% (W / V), 15% (W / V), 0.7% (W / V), 2% (W / V), 0.5% (W / V), divided into containers or sprayed The device is spare.

[0020] The following is an experimental example on the demonstration of the effect of the veterinary tylosin in situ gel pharmaceutical composition.

experiment example

[0021] Experimental example. Therapeutic effect of Tylosin in situ gel pharmaceutical composition on sick piglets

[0022] Experimental animals: randomly select 60 diseased piglets with a body weight of 15-30 kg.

[0023] Test drug: the tylosin in situ gel pharmaceutical composition prepared according to Example 1; 20% tylosin injection (prepared in our laboratory).

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PUM

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Abstract

The invention provides a tylosin in situ gel drug composition which is used for solving the problem that animals, especially piglets, are infected with mycoplasmata, treponematosis, staphylococcus, streptococcus, pasteurella and haemophilus influenzae. Before the piglets suck, the tylosin in situ gel drug composition is directly sprayed or smeared on nipples of sows and can quickly become gel with relatively high viscosity so as to be retained locally, so that the piglets take in tylosin while sucking. The tylosin in situ gel drug composition is convenient to use and ensures the curative effect.

Description

technical field [0001] The invention relates to anti-infection veterinary drugs, in particular to a tylosin in situ gel pharmaceutical composition. Background technique [0002] Mycoplasma pneumonia is a chronic pneumonia caused by Mycoplasma hyopneumoniae, also known as porcine endemic pneumonia. The local pig breeds of this disease in my country are obviously more susceptible than the imported breeds, and the pigs with bacteria are the main source of infection of the disease. The pathogen is transmitted by aerosol or direct contact with respiratory secretions of sick pigs. Passage of the pathogen from sows to piglets perpetuates the disease in the herd, and its severity often varies greatly with changes in management level, season, ventilation conditions, pig density, and other environmental factors. The earliest may occur in piglets aged 2 to 3 weeks, but generally the transmission is slow, infection is more common at 6 to 10 weeks of age, and many pigs do not show obvi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/7048A61P31/00A61P31/04
Inventor 佟丽咸洪军
Owner 佟丽
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