Tylosin in situ gel drug composition for livestock and preparation method thereof
A technology of in-situ gel and tylosin, which is applied in the direction of drug combination, antibacterial drugs, and pharmaceutical formulations, can solve problems such as difficulty in medication for piglets, reluctance of piglets to eat, and cumbersome injection operations.
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Embodiment 1
[0016] Example 1. Preparation of tylosin temperature-sensitive in-situ gel pharmaceutical composition
[0017] Take tylosin phosphate and add water to dissolve, add poloxamer 407 and poloxamer 188, add water to 50mL to fully swell into a uniform solution, add sodium bisulfite and disodium edetate, stir to dissolve, and finally phosphoric acid The concentrations of tylosin, poloxamer 407, poloxamer 188, sodium bisulfite and disodium edetate in the in situ gel were 20% (W / V) and 15% (W / V), respectively. V), 15% (W / V), 2% (W / V), 0.5% (W / V), divided into containers or spray devices for later use.
Embodiment 2
[0018] Example 2. Preparation of tylosin temperature / ion-sensitive in situ gel pharmaceutical composition
[0019] Take tylosin phosphate and add water to dissolve, add poloxamer 407, poloxamer 188, gellan gum, add water to 50mL to fully swell into a uniform solution, add sodium bisulfite and disodium edetate, Stir to dissolve, and finally the concentrations of tylosin phosphate, poloxamer 407, poloxamer 188, gellan gum, sodium bisulfite and disodium edetate in the in situ gel were 20% (W / V), 15% (W / V), 15% (W / V), 0.7% (W / V), 2% (W / V), 0.5% (W / V), divided into containers or sprayed The device is spare.
[0020] The following is an experimental example on the demonstration of the effect of the veterinary tylosin in situ gel pharmaceutical composition.
experiment example
[0021] Experimental example. Therapeutic effect of Tylosin in situ gel pharmaceutical composition on sick piglets
[0022] Experimental animals: randomly select 60 diseased piglets with a body weight of 15-30 kg.
[0023] Test drug: the tylosin in situ gel pharmaceutical composition prepared according to Example 1; 20% tylosin injection (prepared in our laboratory).
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