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Method for preparing nano curcumin particles by utilizing ultrasonic-assisted supercritical anti-solvent

A supercritical anti-solvent and curcumin technology, which is applied in application, food forming, ketone active ingredients, etc., can solve the problems of high organic residue, curcumin denaturation, long processing time, etc., and shorten the anti-solvent transmission. Quality process, particle size is small, the effect of uniform distribution

Active Publication Date: 2014-04-09
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has a long processing time and high temperature, which will denature part of curcumin, and the organic residues are relatively high, so it is difficult to be widely used in the production of drugs and functional foods.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Dissolve curcumin in ethanol under dark conditions, and the concentration of curcumin is 10mg / ml. will CO 2 Pump it into a high-pressure reactor, and after the reactor reaches the preset temperature of 35°C and pressure of 14MPa and stabilizes for 5 minutes, pump the mixed solution of lutein and hydrogenated phospholipids at a flow rate of 1ml / min. After the solution is pumped, continue to pass through the CO 2 After 0.5h, stop feeding CO 2 , release the pressure, and collect the particles in the reactor to obtain curcumin nanoparticles. Its average particle diameter is 945nm, and the recovery rate is 64.5%.

Embodiment 2

[0022] Dissolve curcumin in ethyl acetate under dark conditions, and the concentration of curcumin is 10 mg / ml. will CO 2 Pump into the high-pressure reaction kettle, after the reaction kettle reaches the preset temperature of 35°C and pressure of 10MPa and stabilizes for 5 minutes, pump the mixed solution of lutein and hydrogenated phospholipid at a flow rate of 1ml / min. Turn on the ultrasound and adjust the ultrasound power to 150W. After the solution is pumped, continue to pass through the CO 2 After 0.5h, stop feeding CO 2 , release the pressure, and collect the particles in the reactor to obtain curcumin nanoparticles. Its average particle diameter is 487nm, and the recovery rate is 49.2%.

Embodiment 3

[0024] Dissolve curcumin in ethanol under dark conditions, and the concentration of curcumin is 10mg / ml. will CO 2 Pump into the high-pressure reaction kettle, after the reaction kettle reaches the preset temperature of 35°C and pressure of 14MPa and stabilizes for 5 minutes, pump the mixed solution of lutein and hydrogenated phospholipid at a flow rate of 1ml / min. Turn on the ultrasound and adjust the ultrasound power to 150W. After the solution is pumped, continue to pass through the CO 2 After 0.5h, stop feeding CO2, release the pressure, and collect the particles in the reactor to obtain curcumin nanoparticles. Its average particle diameter is 225nm, and the recovery rate is 62.5%.

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Abstract

The invention relates to a method for preparing nano curcumin particles by utilizing an ultrasonic-assisted supercritical anti-solvent. The method comprises the following steps: adding curcumin into an organic solvent to prepare an organic solution, pumping CO2 into a high-pressure reaction kettle, and regulating the valve opening of the reaction kettle; pumping the prepared organic solution and starting an ultrasonic device after the pressure and temperature in the high-pressure reaction kettle are stabilized and reach preset values, continuing introducing CO2 after the solution is pumped, and keeping the pressure and temperature values in the high-pressure reaction kettle until the organic solvent is dried up to obtain the curcumin particles in the reaction kettle. Compared with the prior art, the method has the advantages of short treatment time, high product purity and low amount of organic solvent residues.

Description

technical field [0001] The invention relates to the fields of medicine and functional food, in particular to a method for preparing nano-curcumin particles by ultrasonic-assisted supercritical antisolvent. Background technique [0002] Curcumin is a natural pigment extracted from turmeric, a plant in the ginger family. It is currently mainly used in the food field as an edible pigment to replace synthetic fuels. Curcumin has a long history as a medicine. Traditional Chinese medicine records that curcumin is pungent, bitter, warm in nature, non-toxic, and can promote blood circulation, promote qi, stimulate menstruation, and relieve pain. Modern medicine has further proved the pharmacological effects of curcumin, such as anti-oxidation, anti-tumor, anti-inflammatory, anti-microbial and so on. [Research Progress of Curcumin. Chinese Herbal Medicine 2009, 40(5), 828-831] Recent studies have found that curcumin has a significant effect in the treatment of cardiovascular and cer...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/12A23P1/02A23P10/20
Inventor 忻娜法蒂玛萨比利贾竞夫王武聪赵亚平
Owner SHANGHAI JIAO TONG UNIV
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