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A kind of Poss-containing superparamagnetic nanomicelle and preparation method thereof

A nanomicelle and superparamagnetic technology, which is applied in the field of POSS-containing superparamagnetic nanomicelle and its preparation, can solve the problems of unsuitability for practical application, low yield, complicated method, etc.

Active Publication Date: 2016-09-07
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of micelles is suitable as a drug controlled release carrier, but the preparation process is relatively complicated, especially the preparation of amphiphilic polymers by the RAFT method, the method is complicated, the yield is low, and it is not suitable for practical application
[0005] At present, superparamagnetic nanomicelle containing POSS has not been reported

Method used

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  • A kind of Poss-containing superparamagnetic nanomicelle and preparation method thereof
  • A kind of Poss-containing superparamagnetic nanomicelle and preparation method thereof
  • A kind of Poss-containing superparamagnetic nanomicelle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Preparation of parental macromolecules containing POSS

[0033] 8.00g POSS, 0.90g maleic anhydride (MA), 0.045g hydroquinone and 50mL toluene were mixed uniformly, nitrogen gas was passed, and POSS-MA was separated and purified after reaction at 90°C for 24 hours; 2.00g POSS-MA , 4.11g PEG2000, 0.025g p-toluenesulfonic acid, 0.051g hydroquinone and 50mL toluene are uniformly mixed, nitrogen gas is passed, and the amphiphilic macromolecule POSS-MA-PEG2000-MA-POSS is obtained by separation and purification after reaction at 135°C for 24 hours .

[0034] (2) Fe 3 o 4 Preparation and Modification of Particles

[0035] 8.12g FeCl 3 ·6H 2 O and 4.17 g FeSO 4 ·7H 2 O was dissolved in 60mL of deionized water; 5.31g of NaOH was dissolved in 10mL of deionized water, and added slowly. After reacting at 65°C for 1 hour, 3.00mL of oleic acid was added, and the temperature was raised to 75°C for 1 hour to obtain a super-silicone with a size of 8-12nm. Magnetic Magnetic Fe...

Embodiment 2～5

[0039]The same process as in Example 1, changing the molecular weight of PEG in step (1) to 600, 800, 1000, 4000 respectively, the results are shown in Table 1.

Embodiment 6～8

[0041] With embodiment 1 technique, change Fe in step (3) 3 o 4 The feeding of particles is 0.020g, 0.025g, 0.30g, and the results are shown in Table 2.

[0042] Table 1

[0043] Example

Micellar particle size (nm)

Micelle Specific Saturation Magnetic Strength (emu / g)

2

88.4

24.6

3

90.1

25.8

4

96.5

23.9

5

120.7

26.2

[0044] Table 2

[0045] Example

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PUM

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Abstract

The invention provides a superparamagnetic nano micelle containing POSS (polyhedral oligomeric silsesquioxane) and a preparation method thereof, and relates to a composite material and a preparation method thereof. The preparation method comprises the following steps: performing simple esterification reaction on aminopropyl POSS, maleic anhydride and polyethylene glycol, thus synthesizing self-crosslinkable amphipathic large molecules containing POSS; preparing Fe3O4 particles of which the particle size is 8-12 nm through a chemical coprecipitation method, and modifying the Fe3O4 particles; and finally, directly assembling the amphipathic large molecules containing POSS and the Fe3O4 particles in the presence of selective solvent, thus obtaining the Fe3O4-inlaid superparamagnetic nano micelle containing POSS. According to the invention, the prepared micelle is high in stability; and the preparation process is simple and favorable in controllability. Thus, the invention has wide application value in the fields of biomedical materials such as catalyst carriers, controlled release of medicaments, chemical separation, magnetic resonance imaging and the like.

Description

technical field [0001] The invention relates to a superparamagnetic nano-micelle and a preparation method thereof, in particular to a POSS-containing superparamagnetic nano-micelle and a preparation method thereof. Background technique [0002] Polyhedral oligomeric silsesquioxane, referred to as POSS, is a compound with a nanometer size. The three-dimensional size is 1-3 nm. It is the smallest silicon particle, and its physical size is on the same order of magnitude as most polymer chain segments. The unique hexahedral structure has small size effect, surface interface effect, quantum size effect, macro quantum tunnel effect, and exhibits special thermal, optical, magnetic and acoustic properties. POSS-based polymer materials are known as "a new generation of high-performance polymer materials". [0003] Polymer macromolecules often contain chain segments with differences in composition, polarity, and solubility. In the polymer body or solution, due to the difference in c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L71/08C08K9/04C08K3/22C08J3/00C08G65/48
Inventor 戴李宗陈凌南吴悦广曾碧榕毛杰王爽许一婷罗伟昂何凯斌刘新瑜
Owner XIAMEN UNIV