Method for preparing epoxy compound standard solution and method for measuring concentration of epoxy compound

A technology of epoxy compounds and standard solutions, which is applied in the direction of measuring devices, preparation of test samples, instruments, etc., can solve the problems of difficult accurate preparation of standard solutions, and achieve the effects of low detection limit, simple operation and high precision

Active Publication Date: 2014-04-16
LIAONING OXIRANCHEM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Due to the low boiling point of epoxy compounds, easy gasification, flammability, explosion, and the difficulty of accurate preparation of standard solutions, departments and units that often need to detect the residual amount of epoxy compounds hope to provide a simple and accurate preparation environment. Oxygen compound standard solution method

Method used

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  • Method for preparing epoxy compound standard solution and method for measuring concentration of epoxy compound
  • Method for preparing epoxy compound standard solution and method for measuring concentration of epoxy compound
  • Method for preparing epoxy compound standard solution and method for measuring concentration of epoxy compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Embodiment 1: prepare the oxirane standard solution of different target concentrations (absorption solvent is deionized water)

[0098] Use the following general operations to prepare ethylene oxide standard solutions with different target concentrations of Cs:

[0099] Take a clean and dry volumetric flask 1 with a stopper and put it on the balance, and reset the balance to zero;

[0100] Add a certain amount of solvent into the volumetric flask, and accurately weigh its mass, denoted as M 1 ;

[0101] Take another 25mL volumetric flask 2 with a certain amount of ethylene oxide liquid, and connect the two volumetric flasks with a latex tube;

[0102] Put the volumetric flask 2 containing the ethylene oxide liquid in a 30°C water bath, let the ethylene oxide gas enter the volumetric flask containing the solvent, and make the absorption equal to or greater than that required for the target ethylene oxide concentration. the amount of ethylene oxide;

[0103] Plug the ...

Embodiment 2

[0115] Embodiment 2 (contrast): adopt the method of prior art to prepare oxirane standard solution

[0116] The national standard GB / T14233.1-2008 of the People's Republic of China provides the preparation method of ethylene oxide standard solution, which involves directly adding liquid ethylene oxide to deionized water as a solvent at low temperature.

[0117] The inventor attempts to prepare ethylene oxide solutions with target concentrations of 0.1%, 0.2%, 0.3%, 0.4%, and 0.5% according to the above method. The specific operations are as follows: take 5 volumetric flasks respectively, and a certain amount of deionized water is housed , accurately weigh the amount of deionized water, take different volumes of ethylene oxide liquid with a precision sampler at -16°C, inject the above-mentioned ethylene oxide liquid into each volumetric flask, and weigh them on the balance. Measure its exact mass. Under the chromatographic condition identical with embodiment 1, the sample of 5...

Embodiment 3

[0119] Embodiment 3: the repeatability of preparing the ethylene oxide standard solution of the same target concentration

[0120] Using the general operation described in Example 1, prepare five standard solutions with target concentrations of 0.1%, that is, absorb different amounts of ethylene oxide and add different amounts of solvents to prepare the same concentration standard solutions, as shown in Table 2 .

[0121] Table 2: According to the preparation method of the present invention target concentration is the ethylene oxide standard solution of 0.1%

[0122] m 1 / g

[0123] As can be seen from the results in Table 2, the method of the present invention can obtain accurate target concentrations for different solution amounts, and the repeatability of the operation is very good.

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Abstract

The invention discloses a method for preparing an epoxy compound standard solution, which comprises the following steps: a, accurately weighing a certain quantity of epoxy compound lyosorption by a weight reduction weighing method; b, adsorbing epoxy compound gas into the epoxy compound lyosorption obtained in the step a so as to obtain a primary epoxy compound solution and determining the quantity of the adsorbed epoxy compound by the weight reduction weighing method; c, adding a certain quantity of epoxy compound lyosorption into the primary epoxy compound solution obtained in the step b and determining the quantity of the added epoxy compound lyosorption by the weight reduction weighing method so as to obtain the epoxy compound standard solution with the target concentration. The invention also discloses a method for measuring the concentration of the epoxy compound by utilizing the epoxy compound standard solution. The methods disclosed by the invention are simple and safe to operate and have high accuracy and good repeatability.

Description

technical field [0001] The invention relates to a detection method for epoxy compounds, more specifically, the invention relates to a method for preparing standard solutions of epoxy compounds and a method for measuring the concentration of epoxy compounds. Background technique [0002] Epoxy compounds are widely used raw materials in chemical, pharmaceutical and other fields. With the expansion of the production and application of epoxy compounds, epoxy compounds also bring certain hazards to human health and the environment, so their content should be strictly tested. [0003] According to the provisions of "The Pharmacopoeia of the People's Republic of China (2010 Edition, Part II)" (edited by the National Pharmacopoeia Committee, China Medical Science and Technology Press, January 2010, pages 1242 to 1244), the medicinal products produced by epoxy compounds should be tested. Residual amount of epoxy compounds in excipients, for example, in polyethylene glycol drug excip...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N30/02G01N30/06
Inventor 朱建民刘兆滨董振鹏周立明徐文斌
Owner LIAONING OXIRANCHEM INC
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