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Biological 3D printing test platform based on CNC milling machine

A CNC milling machine and 3D printing technology, which is applied in the field of biological 3D printing test platform, can solve the problems that the precision of the biological test platform cannot be satisfied, the support cannot be well satisfied, etc., and the modification process is simple and easy, easy to disassemble and assemble, and easy to industrialize. The effect of automation

Active Publication Date: 2017-01-11
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to aim at the existing methods for preparing tissue engineering scaffolds by using traditional methods. The prepared scaffolds cannot well meet the requirements of tissue engineering for scaffolds, and the existing 3D printing manufacturing technology cannot meet the requirements for scaffolds in the field of tissue engineering. The material requirements and the biological experiment platform built by researchers at home and abroad related to the manufacture of tissue engineering scaffolds cannot meet the requirements of the specific contour structure of the scaffold due to reasons such as precision. A biological 3D printing test platform based on a CNC milling machine is provided. The test platform can be applied to a variety of degradable biomaterials, especially suitable for hot-melt polymer materials. It makes full use of the CNC system of the CNC milling machine, and can accurately walk out the contours with more complex shapes, so that it can prepare structures with specific contours Required Tissue Engineering Scaffolds

Method used

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  • Biological 3D printing test platform based on CNC milling machine
  • Biological 3D printing test platform based on CNC milling machine
  • Biological 3D printing test platform based on CNC milling machine

Examples

Experimental program
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Effect test

Embodiment 1

[0032] See figure 1 ~ Image 6 , The biological 3D printing test platform based on CNC milling machine includes: a CNC milling machine (I), which is characterized in that there is also a piston extrusion feeding device (II) and a special connecting piece (III), through the special The connecting piece (Ⅲ) connects the piston extrusion and feeding device with the taper shank of the CNC milling machine (Ⅰ) in a threaded form, thereby obtaining a biological 3D printing test platform, which can make full use of the CNC system of the CNC milling machine (Ⅰ) to make the piston The extrusion feeding device (Ⅱ) is programmed by the CNC milling machine to accurately follow the X / Y / Z three directions to go out of the complicated shape path, while the single-chip microcomputer (29) controls the piston extrusion feeding device (II) to extrude the organism The material is deposited on the receiving platform to realize the preparation of an ideal tissue engineering scaffold.

Embodiment 2

[0034] This embodiment is basically the same as the first embodiment, and the special features are as follows:

[0035] The piston extrusion feeding device (II) includes an extrusion feeding module (21), a feeding controller module (22) and a feeding detection module (23), and the extrusion feeding module (21) is connected to The material controller module (22) and the material supply detection module (23) are connected to the material supply controller module (22) to form a control loop system.

[0036] The special connecting piece (III) is composed of an internally threaded tubular member (31) and a supporting plate (32); one end of the internally threaded tubular member (31) is connected to one end of the supporting plate (32) through 4 bolts Connected, the threaded hole at the other end of the internal threaded tubular member (31) is screwed to the taper shank thread end of the CNC machine tool (I), and the other end of the support plate (32) is fixed with the piston extrusion ...

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Abstract

The invention relates to a biological 3D (three dimensional) printing test platform based on a numerical control milling machine. The biological 3D printing test platform comprises the numerical control milling machine, a piston extrusion supplying device and a special connection member, wherein the special connection member and a taper shank of the numerical control milling machine are connected in a threaded connection mode; a tissue engineering scaffold with high precision, high stability and reasonable profile can be manufactured by fully using a CNC (Computer Numerical Control) system of the numerical control milling machine. The biological 3D printing test platform is based on the improvement of the numerical control milling machine, conventional reduction type manufacturing is changed to 3D printing increase type manufacturing, so that the biological 3D printing test platform cannot be limited by materials, is high in precision, low in cost and convenient to dismount and mount, can be used for achieving the industrial production of the tissue engineering scaffold and has important practical significance for the repair of tissue damage.

Description

Technical field [0001] The invention relates to a biological 3D printing test platform based on a numerical control milling machine, and belongs to the field of biological manufacturing. Background technique [0002] Tissue and organ defects or dysfunction caused by various reasons are the main cause of harm to human health and one of the main causes of patient death. The repair and functional reconstruction of tissue and organ defects are challenges in the medical field. Traditional treatment methods often require the sacrifice of autologous tissues for transplantation repair, which can easily lead to trauma and functional limitation of the donor site. It is a helpless move to "repair wounds with trauma", while allogeneic tissue and organ transplantation suffers from the lack of suitable donors. Great limitation. With the development of medical science, the treatment concept of tissue and organ defects has gradually changed from tissue transplantation to tissue regeneration mod...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C67/00
Inventor 刘媛媛向科李瑜张付华江郑龙胡庆夕
Owner SHANGHAI UNIV