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Drug for treatment of rheumatoid arthritis and preparation method thereof

A technology for arthritis and rheumatoid arthritis, applied in the field of rheumatoid arthritis drugs, to achieve fast drug effect time, reduce toxic and side effects, good drug dispersibility and absorbability

Active Publication Date: 2014-04-30
YUANHE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Synovectomy can relieve the condition to a certain extent, but when the synovium re-proliferates, the condition tends to recur, so DMARD must be used at the same time

Method used

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  • Drug for treatment of rheumatoid arthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]

[0028] Preparation:

[0029] Weigh Aconitum Aconitum, Piper longum, and Myrobalan according to the prescription and crush them into coarse powder, heat and reflux with 70% ethanol to extract twice, the first time for 2 hours, the second time for 1 hour, and the amount of solvent used each time is 8 times the amount of medicinal materials , collect the extract by filtration, recover ethanol under reduced pressure, concentrate to a relative density of 1.12-1.22 (50°C) (about 200ml), add propylene glycol, Tween-80, azone, and sorbic acid to make a uniform dispersion A for later use. Separately take carbomer and distilled water to fully swell to form a 3% coagulation, add triethanolamine and mix to obtain matrix B for later use. Slowly add A into B and continue to stir for 2 hours, pass through a colloid mill to make 1000g of gel.

Embodiment 2

[0031] 500 patients suffering from mild and moderate rheumatoid arthritis are divided into two groups of 250 each, one group takes the gel of the present invention, and the matched group takes Naru Sanwei Pills for treatment, and takes 8 weeks to show significant improvement. The relationship between efficiency and taking time is shown in the table below.

[0032] Table 1, experimental curative effect comparison test (relationship between taking period and marked effect, cure rate in brackets)

[0033]

2 weeks

4 weeks

6 weeks

8 weeks

Drugs of the present invention

60％(12％)

98％(52％)

100％(86％)

100％(96％)

Naru Sanwei Wan

40％(0％)

78％(20％)

90％(66％)

98％(70％)

[0034] Individual cases:

[0035] Feng XX, 40 years old, an employee of a private enterprise in Inner Mongolia, suffered from severe active inflammatory joint pain symptoms, morning stiffness and fatigue were obvious, severe synovitis was found d...

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Abstract

The invention discloses a drug for treatment of rheumatoid arthritis. The drug comprises by weight: the following medicinal components: 300 parts of Radix Aconiti Kusnezoffii Praeparata, 180 parts of piper longum, and 600 parts of Terminalia chebula Retz; the following gel matrix: 12 parts of carbomer 940, 14 parts of triethanolamine, 90 parts of propylene glycol, and 45 parts of Twain-80; the following transdermal penetration enhancers: 45 parts of azone, and 1.5 parts of sorbic acid; a moderate amount of distilled water, with a total of 1000 parts. And the materials are made into a gel, which has the characteristics of quick and good curative effect.

Description

technical field [0001] The invention relates to the field of drugs for rheumatoid arthritis, in particular to a Mongolian medicine for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is a heterogeneous, systemic, autoimmune disease with symmetric polyarthritis as the main clinical manifestation. Heterogeneity means that patients have different genetic backgrounds, and the etiology may not be single, so the pathogenesis is not the same. Clinically, there may be different subtypes (subsets), which are manifested by differences in disease course, severity, prognosis, and outcome. However, the disease is a chronic, progressive, and aggressive disease. If it is not properly treated, the disease will gradually worsen and develop. Therefore, early diagnosis and early treatment are very important. The disease is distributed globally and is one of the main causes of human loss of labor force and disability. [0003] Because the etiology and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61K9/06A61P29/00A61P19/02
Inventor 邬林祥王玉文常绍琴
Owner YUANHE PHARMA CO LTD
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