A kind of medicine for treating rheumatoid arthritis and preparation method thereof

A technology for arthritis and rheumatoid arthritis, applied in the field of rheumatoid arthritis drugs, to achieve fast drug effect time, good curative effect, and reduce toxic and side effects

Active Publication Date: 2016-03-30
YUANHE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Synovectomy can relieve the condition to a certain extent, but when the synovium re-proliferates, the condition tends to recur, so DMARD must be used at the same time

Method used

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  • A kind of medicine for treating rheumatoid arthritis and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]

[0028] Preparation:

[0029] According to the prescription, weigh and pulverize Caowu, longan and myrobalan into coarse powder, and extract twice with 70% ethanol under reflux, the first time is 2 hours, the second time is 1 hour, and the amount of solvent is 8 times the amount of the medicinal materials each time. , the extract was collected by filtration, ethanol was recovered under reduced pressure, concentrated to a relative density of 1.12-1.22 (50° C.) (about 200 ml), and propylene glycol, Tween-80, azone, and sorbic acid were added to make uniform dispersion A for subsequent use. Separately, carbomer was fully swollen with distilled water to make a 3% coagulum, and triethanolamine was added and mixed to obtain a matrix B for later use. Slowly add A into B and continue stirring for 2 hours, pass through a colloid mill, and prepare 1000 g of gel.

Embodiment 2

[0031] 500 patients with mild and moderate rheumatoid arthritis were divided into two groups of 250 each, one group took the gel of the present invention, and the control group took Naru Sanwei Pill for treatment, and after taking 8 weeks, it was significantly The relationship between efficiency and taking time is shown in the table below.

[0032] Table 1, experimental efficacy comparison test (the relationship between taking cycle and markedly effective, the cure rate in parentheses)

[0033]

Two weeks

4 weeks

6 weeks

8 weeks

The medicine of the present invention

60％(12％)

98％(52％)

100％(86％)

100％(96％)

That's like a three-flavored pill

40％(0％)

78％(20％)

90％(66％)

98％(70％)

[0034] Individual cases:

[0035] Feng XX, 40 years old, employee of a private enterprise in Inner Mongolia, suffered from severe active inflammatory joint pain, morning stiffness and fatigue, and severe synovitis was found du...

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PUM

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Abstract

The invention discloses a drug for treatment of rheumatoid arthritis. The drug comprises by weight: the following medicinal components: 300 parts of Radix Aconiti Kusnezoffii Praeparata, 180 parts of piper longum, and 600 parts of Terminalia chebula Retz; the following gel matrix: 12 parts of carbomer 940, 14 parts of triethanolamine, 90 parts of propylene glycol, and 45 parts of Twain-80; the following transdermal penetration enhancers: 45 parts of azone, and 1.5 parts of sorbic acid; a moderate amount of distilled water, with a total of 1000 parts. And the materials are made into a gel, which has the characteristics of quick and good curative effect.

Description

technical field [0001] The present invention relates to the field of rheumatoid arthritis medicines, in particular, to a Mongolian medicine for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is a heterogeneous, systemic, autoimmune disease with symmetrical polyarthritis as the main clinical manifestation. Heterogeneity refers to patients with different genetic backgrounds, and the etiology may not be single, so the pathogenesis is not the same. There may be different clinical subtypes (subsets), manifested in the course, severity, prognosis and outcome will be different. However, this disease is a chronic, progressive and invasive disease. If not properly treated, the disease will gradually worsen and develop. Therefore, early diagnosis and early treatment are very important. The disease has a global distribution and is one of the main causes of human loss of labor and disability. [0003] Because the etiology and pathogenesis of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/714A61K9/06A61P29/00A61P19/02
Inventor 邬林祥王玉文常绍琴
Owner YUANHE PHARMA CO LTD
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