Three-dimensional graphene/hydroxyapatite hydrogel material

A hydroxyapatite and graphene technology, applied in the field of nanocomposite materials and biological materials, can solve the problems of increased preparation cost, insufficient porosity, complicated regulation process, etc., and achieves good drug release effect, high porosity and convenience. effect used
CN103751850AInactive Publication Date: 2014-04-30SOUTHWEST JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN Ā· China
Current Assignee / Owner
SOUTHWEST JIAOTONG UNIV
Publication Date
2014-04-30
Estimated Expiration
Not applicable Ā· inactive patent

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Abstract

The invention provides a three-dimensional graphene / hydroxyapatite hydrogel material. The material is prepared in the following steps: mixing a graphene oxide solution with concentration of 6-10mg / ml and hydroxyapatite size, sufficiently and uniformly stirring to obtain a mixed solution, wherein the mass ratio of the graphene oxide to hydroxyapatite in the mixed solution is 1:(0.5-5); transferring the mixed solution into a hydrothermal reaction kettle, insulating for 0.5-24 hours at 160-200 DEG C to react; cooling to room temperature, and absorbing free water on the surface of the product to obtain the three-dimensional graphene / hydroxyapatite hydrogel material. The material is hydrogel with a network structure, is high in porosity, large in specific surface area and excellent in mechanical performance, can be directly used as bone tissue repairing materials and drug carriers with good treatment and repair effect and excellent drug-loading and drug-release effects.
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Description

technical field

[0001] The invention relates to a three-dimensional graphene / hydroxyapatite hydrogel material, belonging to nanocomposite materials and biological materials. Background technique

[0002] Hydroxyapatite (HA) is a typical biomaterial, the main inorganic component of human bone tissue and teeth, has good biocompatibility and osteogenic activity, and is recognized as a good candidate in the field of bone repair and replacement Bone replacement biomaterials. However, as a bone repair material, hydroxyapatite also has disadvantages such as high brittleness, poor load bearing capacity, and inability to adapt well to different application requirements of clinical bone repair. To solve this problem, hydroxyapatite is often compounded with other materials to achieve the purpose of enhancing mechanical properties.

[0003] Graphene (Graphene or Reduced-Graphene Oxide, RGO), as an emerging nano-scale material, has excellent electrical, mechanical, optical and thermal ...

Claims

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