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A method for analyzing nitrosamine precursors using solid-phase extraction cartridges of different polarities

A technology for nitrosamine precursors and solid-phase extraction cartridges is applied in the field of analyzing nitrosamine precursors, which can solve the problems of complex sources of nitrosamine precursors, achieve simple equipment and operations, and improve treatment effects. , Analysis of the effect of low cost

Active Publication Date: 2015-09-30
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] The sources of nitrosamine precursors are very complex, including natural organic matter, organic matter in sewage plant effluent, industrial and domestic sewage, some pharmaceuticals and personal care products, some chemical raw materials, quaternary ammonium salt flocculants used in water treatment processes and Ion exchange resins, etc.; at the same time, the concentration level of nitrosamine precursors is generally tens to thousands of ng / L, and analysis and testing require the use of very expensive gas chromatography-tandem mass spectrometry or liquid chromatography-tandem chromatography. Currently, there are only a few Research institutes can carry out

Method used

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  • A method for analyzing nitrosamine precursors using solid-phase extraction cartridges of different polarities
  • A method for analyzing nitrosamine precursors using solid-phase extraction cartridges of different polarities
  • A method for analyzing nitrosamine precursors using solid-phase extraction cartridges of different polarities

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Embodiment approach 1

[0043] A method for analyzing precursors of nitrosamines according to different polarities. The main equipment required includes a medical multi-head syringe pump that can precisely adjust the injection speed, which can process multiple samples at the same time; total organic Carbon analyzer (TOC instrument), total nitrogen analyzer, UV-visible spectrophotometer; liquid chromatography-tandem mass spectrometer for the analysis of nitrosamines in water.

[0044] Filter the water sample to be studied with a 0.45um filter membrane to remove particulate matter. Draw the water sample into a 20ml or 50ml all-glass syringe, drain the air bubbles in the water, then connect a C18 or SCX solid-phase extraction column, and place it on a medical syringe pump. Adjust the speed of the syringe pump to control the flow rate of water passing through the solid phase extraction column to 1.5-3.0ml / min. Use a vial that has been treated without carbonization at 500°C to receive the effluent from t...

Embodiment approach 2

[0047] A method for analyzing nitrosamine precursors according to different polarities. The main equipment required includes a solid phase extraction instrument (manual, semi-automatic or fully automatic) that can precisely adjust the flow rate, and can process multiple Samples; total organic carbon analyzer (TOC instrument), total nitrogen analyzer, ultraviolet-visible spectrophotometer for water quality analysis; liquid chromatography-tandem mass spectrometer for water nitrosamine analysis.

[0048] Filter the water sample to be studied with a 0.45um filter membrane to remove particulate matter. Connect the water sample to the solid phase extraction instrument, then connect the C18 or SCX solid phase extraction column, adjust the flow rate of the solid phase extraction instrument, and control the flow rate of water passing through the solid phase extraction column to 1.5-3.0ml / min. Use a vial that has been treated without carbonization at 500°C to receive the effluent from...

Embodiment approach 3

[0051] A method for analyzing nitrosamine precursors according to different polarities, the main equipment required includes a peristaltic pump that can precisely adjust the flow rate, and can process multiple samples at the same time; total organic carbon for water quality analysis Analyzer (TOC instrument), total nitrogen analyzer, UV-visible spectrophotometer; liquid chromatography-tandem mass spectrometer for the analysis of nitrosamines in water.

[0052] Filter the water sample to be studied with a 0.45um filter membrane to remove particulate matter. Connect the water sample to the peristaltic pump, then connect the C18 or SCX solid-phase extraction column, adjust the flow rate of the solid-phase extraction instrument, and control the flow rate of water passing through the solid-phase extraction column to 1.5-3.0ml / min. Use a vial that has been treated without carbonization at 500°C to receive the effluent from the solid phase extraction cartridge.

[0053] Test the nit...

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Abstract

The invention discloses a method for analyzing a nitrosamine precursor by using solid-phase extraction cartridges with different polarities, and belongs to the field of water supply and drainage. The method is characterized in that chromatographic pure methanol and pure water are used for cleaning the solid-phase extraction cartridges when basic polarity characteristics of the nitrosamine precursor in water are analyzed; a water sample is filtered through a 0.45 micron filter membrane, and passes through the solid-phase extraction cartridges at constant flow speed of 1.0 to 2.0ml / min, and indexes including generation potential and the like of the nitrosamine in inflow and effluent are tested respectively; when nonpolar octoalkane solid-phase extraction cartridge (called C18 for short) is selected, polar and nonpolar nitrosamine precursor concentration distribution information can be obtained; when a strong cation exchange resin solid-phase extraction cartridge (called SCX for short) is selected, electronegative and uncharged nitrosamine precursor concentration distribution information can be obtained.

Description

technical field [0001] The invention relates to a method for analyzing precursors of nitrosamines according to different polarities and charges, and belongs to the field of water supply and drainage treatment. Background technique [0002] Nitrosamines are a class of strong carcinogens. At present, research has confirmed that nine kinds of nitrosamines, such as dimethylnitrosamine (NDMA), diethylnitrosamine (NDEA), and dipropylnitrosamine (NDPA), can be produced in the process of water supply and drainage disinfection treatment. . In water treatment, nitrosamine substances mainly come from precursors containing dialkylamine structures in water. For example, dimethylamine is the direct precursor of dimethylnitrosamine. In addition, some medicines, water purification agents, Sewage plant effluent and domestic sewage can also contribute high levels of nitrosamine precursors. Chloramine disinfectants commonly used in water treatment can react with nitrosamine precursors to ge...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06G01N1/34G01N33/18
Inventor 陈超张晓健廖晓斌汪隽李士翔
Owner TSINGHUA UNIV