Compound albendazole dry suspension and preparation method thereof

Abstract

The invention discloses a compound albendazole dry suspension and a preparation method thereof. The dry suspension comprises albendazole, ivermectin, diluting agent, wetting agent, dispersing agent and suspending agent in a weight ratio of 10:0.2:(10-15):1:2:(0.3-0.6). The suspension is simple in preparation process, can be quickly and uniformly dispersed in water in clinical application, is beneficial to clinical administration, is good in absorption and quick in response. Furthermore, addition of ivermectin into albendazole can enlarge the parasite-expelling spectrum of a medicine, and the dry suspension can be used for expelling and killing trematode, cestode, nematode and ectozoa.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations. A method for preparing an anthelmintic compound albendazole dry suspension for animals is specifically designed. Background technique [0002] Albendazole is a low-toxicity, high-efficiency, broad-spectrum antiparasitic drug of the benzimidazole class. It has a strong killing effect on nematodes, tapeworms and trematodes in animals. Its mechanism of action is mainly to bind to the tubulin of the worm body to destroy the basic structure of the worm body, and block cells such as mitosis, protein assembly and energy metabolism. reproductive process. Albendazole not only has a strong effect on adults, but also has a strong killing effect on immature insects, larvae, and eggs. Oral absorption is better. [0003] Ivermectin is an antibiotic anthelmintic. In addition to its supplementary and synergistic effect on albendazole to kill trematodes, nematodes and tapeworms in the body, it also ...

AI Technical Summary

Problems solved by technology

① After the tablet enters the body, it must be wetted and disintegrated before the drug can be released and absorbed slowly, with a long peak time, slow action and low bioavailability

②Powder is used for mixing and administration, but due to the influence of feed type, particle size, feed intake, etc., uneven mixing and uneven intake result in inaccurate deworming effec...