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Preparation method and application of supramolecular nanoscale polymer for multi-functional imaging

A nano-polymer and supramolecular technology, applied in the preparations and pharmaceutical formulations for in vivo experiments, can solve the problems of damage, low sensitivity, long detection time, etc., and achieve broad application prospects, strong bonding ability, and enhanced relaxation. The effect of hedonicity

Inactive Publication Date: 2014-06-18
NANKAI UNIV
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Problems solved by technology

For example, spectral imaging has high sensitivity and high temporal resolution, but its penetration and spatial resolution have limited its further application; magnetic resonance imaging has no ionizing radiation (radiation) damage, no bone artifacts, and can Direction (transverse, coronal, sagittal, etc.) Long and expensive to test
At the same time, a single imaging technology cannot meet the increasing needs of medical diagnosis

Method used

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  • Preparation method and application of supramolecular nanoscale polymer for multi-functional imaging
  • Preparation method and application of supramolecular nanoscale polymer for multi-functional imaging
  • Preparation method and application of supramolecular nanoscale polymer for multi-functional imaging

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Embodiment

[0030] A preparation method for supramolecular nanopolymers, comprising the steps of:

[0031] 1) Add 2.3g of 6-azido-6-deoxy-b-cyclodextrin and 1g of 6-azido-6-deoxy-permethylated b-cyclodextrin in sequence under the protection of argon to dissolve 100 mL of dimethyl In formamide solvent, stirred at 25°C for 24 hours, the solvent was removed by rotary evaporation, and the remaining solid was purified with a dialysis bag to obtain a white trisCD solid with a yield of 60%.

[0032] 1 H NMR (400 MHz, D 2 O) δ 8.11 (s, 3H), 7.33 – 6.49 (m, 12H), 5.46 – 4.84 (m, 27H), 4.63 – 2.61 (m, 246H), 2.02 (s, 3H). 13 C NMR (100 MHz, D 2 O) δ 156.0, 154.1, 146.4, 143.5, 140.8, 140.5, 129.1, 126.3, 118.2, 118.1, 114.8, 102.2, 97.3, 83.3, 82.3, 82.0, 81.5, 81.0, 80.5, 80.1, 79.1, 78.4, 77.6, 77.4 , 73.2, 72.0, 71.4, 70.7, 70.4, 69.7, 62.8, 61.6, 61.3, 61.1, 60.6, 60.0, 59.6, 59.5, 59.0, 58.7, 58.3, 58.1, 51.4, 32.6, 290.6 m / z: [M+Na] + calcd for C 195 h 311 o 105 N 9 Na + 4481.91...

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Abstract

The invention relates to a preparation method of a supramolecular nanoscale polymer for multi-functional imaging. A building unit uses bridging tri-b-cyclodextrin as a main body, and polyethylene glycol modified metal manganese porphyrins as an object, so that a molecule assembly body is built by the inclusion complexation interaction of the main body and the object. The supramolecular nanoscale polymer for multi-functional imaging is used for target imaging in MCF7 cells and target imaging in KB cells. The preparation method provided by the invention has the advantages that the supramolecular nanoscale polymer is assembled and built by the bridging tri-b-cyclodextrin and water-soluble metal porphyrin binary supramolecule, the process is simple, the ability of bonding between components is stronger; the prepared supramolecular nanoscale polymer itself can effectively enhance the relaxation degree of water, and can be used as a magnetic resonance imaging (mri) contrast agent, and meanwhile, the natural cyclodextrin provides sites for multi-functionalization, the requirement of on-demand preparation can be realized, and the supramolecular nanoscale polymer has broad application prospects in the filed of medical contrast agents.

Description

technical field [0001] The invention belongs to nano-supramolecular materials, in particular to the preparation and application of a supramolecular nano-polymer for multifunctional imaging. Background technique [0002] X-ray computed tomography (CT), positron emission tomography (PET), single photon emission computed tomography (single photon emission CT, SPECT), spectral imaging (?uorescence imaging ) and Magnetic Resonance Imaging (Magnetic Resonance Imaging) are commonly used medical imaging techniques today. Different imaging technologies have their own advantages and disadvantages and scope of application. For example, spectral imaging has high sensitivity and high temporal resolution, but its penetration and spatial resolution have limited its further application; magnetic resonance imaging has no ionizing radiation (radiation) damage, no bony artifacts, and more Direction (transverse, coronal, sagittal, etc.) Long and expensive to test. At the same time, a singl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K49/00
Inventor 刘育孙默张衡益赵倩胡心悦刘博闻
Owner NANKAI UNIV
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