42 results about "Manganese porphyrin" patented technology

The invention relates to a manufacturing method of a graphene-porphyrin modified electrode and application of the electrode, aiming to solve the problems of complex operation, long time and relatively high price in the conventional method for detecting the content of ascorbic acid in a living body. The method comprises the following steps: I, preparing pre-oxidized graphene; II, preparing a graphene oxide solid; III, preparing acyl-chlorinated graphene; IV, preparing tetraphenylporphyrin; V, preparing 5-(4-nitro)-10,15,20-triphenyl porphyrin; VI, preparing 5-(4-amino)phenyl-10,15-20-triphenyl porphyrin; VII, preparing a pure manganese porphyrin coordination compound; VIII, preparing a functional composite material of graphene oxide and porphyrin; IX, modifying a glassy carbon electrode. The modified electrode has excellent interference resistance, stability and reproducibility, and can be taken as a biosensor for detecting ascorbic acid in practical samples.

The invention provides a preparation method of intermediate 4AA of the penem medicine, which belongs to the technology field of medicine. The method uses compound shown as formula I as the raw material in the presence of manganese-porphyrin complex compound as the catalyst, decarboxylation oxidizing with oxidizer, and oxidizing with O3 for removing the protective group to obtain 4AA.

The invention relates to a preparation method and application of a graphene oxide supported quadri (4-carboxyphenyl) manganese porphyrin catalysis material. The preparation method comprises the following steps of: firstly preparing graphene oxide by an improved Hummers method, enabling graphite oxide to be ultrasonically dispersed in water to obtain the graphene oxide, then adding the graphene oxide to quadri (4-carboxyphenyl) manganese porphyrin dissolved by N. N-dimethyl formamide, performing ultrasonic treatment at the temperature of 50 DEG C for 5 hours, and performing pressure reduction and suction filtration so as to obtain filter cakes; and drying the obtained filter cakes at 70 DEG C for 36h so as to obtain the required catalysis material. The preparation method of the catalysis material is raid and simple, low in cost, and low in energy consumption; the catalysis material is used for catalyzing oxygen for oxidizing toluene so as to generate benzaldehyde and benzyl alcohol, the highest conversion ratio reaches 16.3%, and the yield of alcohol ketone is 5.8%; and in addition, the catalyst is convenient to recover, after cyclic catalysis for 7 times, the catalysis efficiency is not reduced obviously, and the catalysis material has practical application values, and is an ideal biomimic catalyst.

The invention discloses a preparation method of a graphene oxide@polymerizing metalloporphyrin composite nanometer catalyst with a shell-core coating structure for high-efficiency electrocatalytic reduction of nitrobenzene. The preparation method comprises the following steps of fixedly loading tetraaminophenyl manganese porphyrins onto the surface of graphene oxide by a covalent bonding method, and then coupling with the loaded manganese porphyrins via a conjugated bridging agent, so as to obtain a graphene oxide compound coated by a manganese porphyrins polymer film, namely the graphene oxide@polymerizing metalloporphyrin composite nanometer material. Proofed by the experiment results of electrocatalytic reduction of nitrobenzene using the graphene oxide@polymerizing metalloporphyrin compound, the preparation method has the advantages that under the synergistic function of the graphene oxide and the polymerizing metalloporphyrin film, compared with the glass carbon electrode modifiedby the graphene oxide, the reduction potential of the glass carbon electrode modified by the graphene oxide@polymerizing metalloporphyrin composite nanometer material is positively displaced with 50mV or above, and the more positive reduction potential is displayed; the response of the reduction current is more sensitive, the property is more stable, the property of nitrobenzene after catalytic reduction is more excellent, and the higher application value is realized in the electrochemical detection of trace nitrobenzene in the environment.

The invention provides a preparation method of a super-molecular nano fiber for magnetic resonance imaging radiography. A construction unit takes diPMCD as a main body; manganese porphyrin is taken as a secondary body; and a super-molecular assembly body is constructed by mutual inclusion and complexation effects of the main body and the secondary body. The preparation method comprises the following steps of: dissolving 6-isothiocyano-6-deoxy-fully methylated beta-cyclodextrin and ethanediamine into acetonitrile under the protection of argon; agitating at a room temperature for one night; carrying out spinning evaporation to remove a solvent; purifying a residual solid by using column chromatography to obtain a white diPMCD solid; dissolving the diPMCD and the manganese porphyrin into water and mixing uniformly; and adding sodium ascorbate to obtain a target object. The preparation method has the advantage of being is simple and the components have relatively strong bonding capability; the super-molecular nano fiber can be effectively imaged in a body of a mouse and has a wide application prospect in the field of a magnetic resonance imaging contrast agent; and the invention provides a novel method for preparing the contrast agent.

The invention discloses a magnetic nanoparticle compound for a T1 and T2 bimodal magnetic resonance contrast medium and a preparation method thereof. The magnetic nanoparticle compound is of a three-layered core-shell structure. The cores are Fe3O4 nanoparticles, the middle layer is a silicon dioxide layer of manganese-porphyrin hydrochloride, and the outermost layer is an acrylic acid polymer layer of cyclopeptide radial-cRGD of a targeted integrin receptor. The preparation method comprises the following steps: 1, preparing OA@Fe3O4@nSiaO2@mSiO2; 2, preparing OA@Fe3O4@nSiO2@mSiO2@PAA-cRGD; 3, preparing manganese-porphyrin hydrochloride; and 4, preparing Mn-IOSP. The magnetic nanoparticle compound is used for preparing a new generation T1 and T2 bimodal magnetic resonance contrast medium which is high in relaxation rate, low in toxicity and long in circulating time. The magnetic nanoparticle compound can improve the imaging performance and accuracy, and has good biocompatibility.

The invention relates to a preparation method and catalytic application of a graphene oxide immobilized tetra(4-hydroxyphenyl) manganese porphyrin catalytic material. The preparation method consists of the following steps: first, preparing graphite oxide by an improved Hermes method, preparing fluffy graphene oxide by microwave heating of the graphite oxide, then adding the fluffy graphene oxide into a tetra(4-hydroxyphenyl) manganese porphyrin solution dissolved by N,N-dimethylformamide, carrying out ultrasonic treatment at normal temperature for 6 hours, carrying out vacuum filtration, collecting filter cakes, and drying the filter cakes at 60 DEG C for 48 hours to obtain the required catalytic material. The catalytic material is applied to catalyzing oxygen to oxidize ethylbenzene to generate acetophenone and DL-1-phenylethanol; and under a reaction condition without adding any solvent or reducing agent, the conversion rate reaches 62.7%, and the yield of alcohol ketone is 42.0%. Inaddition, the catalyst can be reused for 5 times for cyclic catalysis, and still shows a good catalytic effect, and the catalyst has a practical application value and is an ideal biomimetic catalyst.

The invention provides preparation of supramolecular dendritic nano aggregate for magnetic resonance imaging contrast. A construction unit utilizes bridged trimer full-methylated beta-cyclodextrin as a subject and utilizes manganese porphyrin as an object, and a supramolecular assembly is constructed through subject-object inclusion complexation interaction. The preparation method comprises the following steps: 1) dissolving 6-isothiocyano-6-deoxy-fully methylated beta-cyclodextrin and tri(2-aminoethyl) in acetonitrile under argon protection, stirring the solution at room temperature overnight, removing the solvent by rotary evaporating, purifying the residual solid through column chromatography to obtain faint yellow solid; and 2) dissolving the solid and manganese porphyrin in water, and uniformly mixing the ingredients, and adding sodium ascorbate to prepare the target object. The preparation method provided by the invention has the advantages that the ingredients of the supramolecular dendritic nano aggregate have strong bonding ability and can effectively improve the water relaxation ability, thereby having a broad application prospect in the field of magnetic resonance imaging contrast agents; and the preparation method is simple and is beneficial to realizing large-scale popularization and application.

The invention provides a measuring method of porphyrin and metal porphyrin content. Firstly, the invention adopts thin-layer chromatography to detect sample purity, adopts a spectroscopic method for quantitative determination, adopts a spectrophotometer to respectively measure the absorbance value of tetraphenylporphyrin, tetraphenyl cobalt porphyrin, tetraphenyl iron porphyrin and tetraphenyl manganese porphyrin at the maximum wavelength adsorption position and utilizes measuring data to calculate porphyrin compound content in the sample. The invention has stable and accurate measuring result, favourable repeatability, few needed devices, simple operation and strong practicality, is especially suitable for synthesizing tetraphenylporphyrin and metal complex thereof and is suitable for quantitative determination of catalyst content when biomimetic catalysis cyclohexane produces cyclohexanol and cyclohexanone by taking tetraphenyl metal porphyrin as catalyst. The invention can provide convenient, quick, accurate, stable and practical analysis means for measuring content of porphyrin and metal porphyrin thereof and the content in biomimetic catalysis researching process, and is especially suitable for quickly analysis and tracking measurement of tetraphenyl metal porphyrin content.

The invention discloses preparation and application of a heterogeneous binuclear metallic complex. The heteronuclear complex consists of an iridium complex and a manganese porphyrin complex; the structure formula of the heteronuclear complex is shown as follows. The complex is high in relaxivity and is capable of realizing magnetic resonance imaging application; and meanwhile, the complex is highin singlet oxygen quantum yield; ROS can be produced in cells, and the good photodynamic treatment can be confirmed by observing the change of the cellular morphology before and after the operation. The complex has a good application prospect in the magnetic resonance imaging and the photodynamics therapy.

The present invention discloses a photoelectric chemical biosensor based on a DNA nanometer dendrite amplifying signal as well as a preparation method and application of the photoelectric chemical biosensor. A technical solution of the present invention is that trace DNA triggers an exonuclease III to provide assistance for a cyclic amplification reaction so as to generate a great number of product chains, DNA rolling circle amplification is combined with chained hybridization to form a nanometer dendrite, a great deal of manganese porphyrin is embedded into the nanometer dendrite to quench abismuth sulfide photoelectric signal, and thus, a simple, convenient and practical photoelectric chemical (PEC) sensor is prepared to realize ultrasensitive detection of the trace DNA and achieve a favorable application potential in fields such as clinical diagnosis, gene therapy, environmental monitoring and food safety.

A preparation method of camphor manganese porphyrin comprises the following steps: reducing 5,10,15,20-tetra(4-nitro substituted phenyl) porphyrin to 5,10,15,20-tetra(4-amido substituted phenyl) porphyrin with stannous chloride in a system of concentrated hydrochloric acid; acylating with camphorone acyl chloride to synthesize 5,10,15,20-tetra(4-camphorone amido substituted phenyl) porphyrin; andintroducing manganese metal with an epoxidation catalysis performance into a center of 5,10,15,20-tetra(4-camphorone amido substituted phenyl) porphyrin to coordinate with porphyrin to form manganese(III) porphyrin. Camphor manganese porphyrin prepared in the present invention can be applied to the epoxidation reaction of alpha, beta-unsaturated ketone, and can be used to catalyze the epoxidation of alpha, beta-unsaturated ketone by hydrogen peroxide in an alkaline condition, so alpha, beta-unsaturated ketone can be almost completely converted into epoxidation products of alpha, beta-unsaturated ketone in a short time, and the catalysis efficiency is high.

The invention discloses a preparation method of a T1-MRI imaging guided photo-active therapeutic agent. The method comprises the following steps: preparing nano-particles having a gadolinium (manganese)-porphyrin metal organic frame structure; preparing a protein / sulfadiazine compound; mixing the nanoparticles with the compound to prepare a bovine serum albumin / sulfadiazine-gadolinium (manganese) porphyrin composite nanomaterial, and using the photo-active effect of the composite nanomaterial under the guidance of T1-MRI to prepare the photo-active therapeutic agent. The T1-MRI imaging guided photo-active therapeutic agent is a composite material having a protein / sulfadiazine-gadolinium (manganese) porphyrin metal organic frame structure, the prepared composite material has very good biocompatibility and low cytotoxicity, and a result of MTT test proves that the composite material can trigger the photo-active effect under the illumination of 660 nm laser, and can kill the tumor cells. The prepared composite material is a very good T1-MRI contrast agent, can be used for the screening and guided photo-active therapy of tumors, and has great potential application values in the field of treatment of tumors.

The invention relates to an aptamer and manganese porphyrin catalysis-based chemiluminescence protein detection method, which aims at solving the technical problems that an aptamer-based protein detection method is low in sensitivity, poor in stability, complicated in steps, high in cost and the like. The method comprises the following steps: (1) preparing a manganese porphyrin probe; and (2) detecting protein, namely adding 20mM Tris-HCl, 25microM luminol and 0.05% Triton X-100 into a chemical reactor, then adding the manganese porphyrin probe, finally, adding a solution containing an aptamer and the to-be-detected protein, placing the chemical reactor into a chemiluminescence detector, finally, adding 1000mM H2O2 with a trace injector, and recording the change of chemiluminescence along time. The method is an aptamer induction-based fast, sensitive, specific and simple protein detection method which is established by gathering manganese porphyrin.

The invention discloses an Au@MnPS catalyst as well as a preparation method and use thereof. According to the preparation method, MnPS is prepared and is loaded with nanogold to form the Au@MnPS catalyst, wherein MnPS is used as a carrier of the catalyst, and a manganese porphyrin structure in Au and MnPS is taken as a main active component of the catalyst and has relatively high loading efficiency and relatively good dispersion degree. The catalyst provided by the invention has the characteristics of high activity and good selectivity in the preparation of cyclohexene oxide from cyclohexene through epoxidation and meets the requirements of industrial production.

To provide a therapeutic agent for disease capable of delivering iron or manganese porphyrin complex possessing the ability to remove active oxygen, principally to abnormal tissue in a living body to effectively remove the active oxygen therefrom, with a high degree of pharmacological effectiveness and without side effects. [Solution] A therapeutic agent for disease containing, in nano-size nanocapsules, iron or manganese containing porphyrin complex encapsulated iron or manganese porphyrin complex nanocapsules, to treat diseases of abnormal tissue by delivering iron or manganese porphyrin complex in nanocapsules into the abnormal tissue that has a high concentration of active oxygen, without affecting normal tissue that has a low concentration of active oxygen and without side effects.

The invention relates to a preparation method of a supramolecular nanoscale polymer for multi-functional imaging. A building unit uses bridging tri-b-cyclodextrin as a main body, and polyethylene glycol modified metal manganese porphyrins as an object, so that a molecule assembly body is built by the inclusion complexation interaction of the main body and the object. The supramolecular nanoscale polymer for multi-functional imaging is used for target imaging in MCF7 cells and target imaging in KB cells. The preparation method provided by the invention has the advantages that the supramolecular nanoscale polymer is assembled and built by the bridging tri-b-cyclodextrin and water-soluble metal porphyrin binary supramolecule, the process is simple, the ability of bonding between components is stronger; the prepared supramolecular nanoscale polymer itself can effectively enhance the relaxation degree of water, and can be used as a magnetic resonance imaging (mri) contrast agent, and meanwhile, the natural cyclodextrin provides sites for multi-functionalization, the requirement of on-demand preparation can be realized, and the supramolecular nanoscale polymer has broad application prospects in the filed of medical contrast agents.

The invention relates to a method for preparing epoxy compounds by catalyzing the oxidation of alpha-olefins by metalloporphyrins. The steps are: in the presence of oxidant air or oxygen, dichloromethane or ethanol is used as a solvent, and a mononuclear metalloporphyrin or μ-oxo binuclear metalloporphyrin with a concentration of 1-50PPM is selected as a catalyst. ℃ and under normal pressure for 0.5-10 hours to catalyze the oxidation of α-olefins to generate epoxy compounds. The aforementioned α-olefins are C6-C18 α-olefins, preferably C11-C18 α-olefins. The catalyst is preferably mononuclear metalloporphyrin or μ-oxo binuclear metalloporphyrin whose metal atoms M1 and M2 are manganese, and the catalyst concentration is preferably 2-20PPM. The method has mild reaction conditions, high conversion rate of olefin, high selectivity of epoxy compound and high yield.

The invention discloses a manganese (III) porphyrin pentamer contrast agent applied to magnetic resonance imaging and application thereof. A preparation method of the contrast agent comprises the following steps of: mixing 5- (4-formylphenyl-10, 15, 20-tri (4-sulfophenyl) manganese (III) porphyrin (Mn-FTPPS) with 5, 10, 15, 20-tetra (4-aminophenyl) manganese (III) porphyrin (Mn-TATPP) according to a molar ratio of 4: 1, dissolving the mixture in DMSO to form a solution with a concentration of 8mg / mL, reacting at 60 DEG C for 4 hours, removing the solvent after the reaction is finished, dialyzing in a dialysis bag of 1000kDa for 48-72 hours, and performing freeze drying for 24-36 hours, thereby obtaining the final carbon-nitrogen double bond bonded manganese (III) porphyrin pentamer contrast agent (MnP5). The contrast agent is high in molecular relaxation efficiency and excellent in biocompatibility and has excellent magnetic resonance imaging capacity in aqueous solution and mouse bodies.

The invention discloses an Au@MnPS catalyst as well as a preparation method and use thereof. According to the preparation method, MnPS is prepared and is loaded with nanogold to form the Au@MnPS catalyst, wherein MnPS is used as a carrier of the catalyst, and a manganese porphyrin structure in Au and MnPS is taken as a main active component of the catalyst and has relatively high loading efficiency and relatively good dispersion degree. The catalyst provided by the invention has the characteristics of high activity and good selectivity in the preparation of cyclohexene oxide from cyclohexene through epoxidation and meets the requirements of industrial production.

A disease treatment drug having high pharmacological effects and no side effects is provided, the disease treatment drug being capable of intensively delivering an iron or manganese porphyrin complex capable of removing active oxygen to abnormal tissue within a living body, and effectively removing the active oxygen within the abnormal tissue. The disease treatment drug contains an iron or manganese porphyrin complex nanocapsule housing an iron or manganese porphyrin complex within a nanosized capsule. In the disease treatment drug, disease of abnormal tissue having a high concentration of active oxygen can be treated by the iron or manganese porphyrin complex delivered into the abnormal tissue as a result of the nanocapsule, without affecting normal tissue having a low concentration of active oxygen, and side effects can be suppressed.

The invention mainly relates to a method for synthesizing folic acid by oxidizing 6-R-tetrahydrofolic acid. The process for synthesizing folic acid by oxidizing 6-R-tetrahydrofolic acid is realized by the following method: adding a certain amount of hydrogen peroxide and a nickel porphyrin / manganese porphyrin composite catalyst loaded on a macroporous molecular sieve into the remaining mother liquor obtained by resolving 6-S-tetrahydrofolic acid benzoate crystals by taking benzoate as a resolving agent, and reacting for a period of time at low temperature to obtain folic acid. And monitoring the reaction by TLC, and filtering and recovering the composite catalyst after the reaction is finished. And carrying out vacuum concentration on the reaction liquid, cooling and standing to obtain a folic acid crude product. According to HPLC analysis, the purity of the crude product folic acid is greater than 95.2%, the purity of the refined folic acid after ethanol recrystallization is greater than 98.5%, and the yield of the refined folic acid is greater than 90% according to the content of 6-R-tetrahydrofolic acid in the resolution mother liquor.

The invention relates to a method for selectively oxidizing styrene in water, which comprises the following steps: adding styrene, a catalyst and an oxidant into a reaction solvent, carrying out oxidation reaction at 25-55 DEG C, and filtering the obtained product after the oxidation reaction to obtain filtrate; wherein the reaction solvent is water; the oxidizing agent is cumyl hydroperoxide or a hydrogen peroxide solution; the catalyst is polymanganese porphyrin. A reaction solvent for oxidizing styrene is water which replaces a traditionally used organic solvent, the method is safe, cheap, non-toxic and pollution-free and conforms to the modern green chemistry concept, a polymanganese porphyrin catalyst is used and matched with an oxidizing agent, a selective catalytic reaction is efficiently carried out in a water solvent, and the system is short in reaction time, high in conversion rate and relatively high in selectivity.

The invention discloses preparation and application of a heterogeneous binuclear metallic complex. The heteronuclear complex consists of an iridium complex and a manganese porphyrin complex; the structure formula of the heteronuclear complex is shown as follows. The complex is high in relaxivity and is capable of realizing magnetic resonance imaging application; and meanwhile, the complex is highin singlet oxygen quantum yield; ROS can be produced in cells, and the good photodynamic treatment can be confirmed by observing the change of the cellular morphology before and after the operation. The complex has a good application prospect in the magnetic resonance imaging and the photodynamics therapy.

The invention discloses a magnetic nanoparticle compound for a T1 and T2 bimodal magnetic resonance contrast medium and a preparation method thereof. The magnetic nanoparticle compound is of a three-layered core-shell structure. The cores are Fe3O4 nanoparticles, the middle layer is a silicon dioxide layer of manganese-porphyrin hydrochloride, and the outermost layer is an acrylic acid polymer layer of cyclopeptide radial-cRGD of a targeted integrin receptor. The preparation method comprises the following steps: 1, preparing OA@Fe3O4@nSiaO2@mSiO2; 2, preparing OA@Fe3O4@nSiO2@mSiO2@PAA-cRGD; 3, preparing manganese-porphyrin hydrochloride; and 4, preparing Mn-IOSP. The magnetic nanoparticle compound is used for preparing a new generation T1 and T2 bimodal magnetic resonance contrast medium which is high in relaxation rate, low in toxicity and long in circulating time. The magnetic nanoparticle compound can improve the imaging performance and accuracy, and has good biocompatibility.

The invention relates to a manufacturing method of a graphene-porphyrin modified electrode and application of the electrode, aiming to solve the problems of complex operation, long time and relatively high price in the conventional method for detecting the content of ascorbic acid in a living body. The method comprises the following steps: I, preparing pre-oxidized graphene; II, preparing a graphene oxide solid; III, preparing acyl-chlorinated graphene; IV, preparing tetraphenylporphyrin; V, preparing 5-(4-nitro)-10,15,20-triphenyl porphyrin; VI, preparing 5-(4-amino)phenyl-10,15-20-triphenyl porphyrin; VII, preparing a pure manganese porphyrin coordination compound; VIII, preparing a functional composite material of graphene oxide and porphyrin; IX, modifying a glassy carbon electrode. The modified electrode has excellent interference resistance, stability and reproducibility, and can be taken as a biosensor for detecting ascorbic acid in practical samples.

The invention discloses a method for preparing cyclic carbonate by a manganese-based catalyst. On the basis of carbon dioxide and epoxides as raw materials, a conjugated manganese porphyrin dipyridine / conjugated manganese porphyrin dipyrrole microporous polymer material as a heterogeneous catalyst and tetra-n-butylammonium bromide as a promoter, efficient and green catalyzed synthesis of cyclic carbonate is realized under the condition of normal temperature and normal pressure in the absent of a solvent. The method has the main advantages that a preparation method of the catalyst is simple, and the catalyst is low in cost, high in catalytic activity, stable in structural performance, easy to recover and recyclable. Reaction conditions are mild, the reaction rate is high, and operation is safe, so that the method is suitable for large-scale industrial production.

The invention discloses a preparation method of a graphene quantum dot modified metalloporphyrin nanotube-cadmium sulfide composite photosensitive sensing material. The preparation method comprises the following steps: firstly preparing tetraphenylporphyrin, then preparing water soluble manganese tetrasulfophenyl porphyrin by taking fuming sulfuric acid as a sulfur source, and growing manganese tetrasulfophenyl porphyrin nanotubes on a porous alpha-alumina substrate; then by taking thioacetamide and cadmium acetate as sources, growing cadmium sulfide nanosheet blades on stems of the manganesetetrasulfophenyl porphyrin nanotubes by utilizing a hydrothermal method, and dropwise adding polydimethylsiloxane solution dissolved with graphene quantum dots on the surface of a composite material,and reserving a manganese tetrasulfophenyl porphyrin nanotube / cadmium sulfide composite material after the porous alpha-alumina substrate is removed, so that protective effect of a support material istaken, and then stability of the sensing material and electron conductivity are improved.

The invention provides a manganese porphyrin compound, which is four-p-ferrocenyl undecyloxyphenyl manganese porphyrin, and its chemical structural formula is as follows: Four-p-ferrocenyl undecyloxyphenyl When manganese porphyrin compounds are used as electrode materials for supercapacitors, the synergistic effect of ferrocene groups and manganese porphyrin structural units makes them have excellent redox characteristics, fast charge and discharge, and good cycle stability, which can further improve Properties of manganese-based pseudocapacitors.

The invention provides a preparation method of a super-molecular nano fiber for magnetic resonance imaging radiography. A construction unit takes diPMCD as a main body; manganese porphyrin is taken as a secondary body; and a super-molecular assembly body is constructed by mutual inclusion and complexation effects of the main body and the secondary body. The preparation method comprises the following steps of: dissolving 6-isothiocyano-6-deoxy-fully methylated beta-cyclodextrin and ethanediamine into acetonitrile under the protection of argon; agitating at a room temperature for one night; carrying out spinning evaporation to remove a solvent; purifying a residual solid by using column chromatography to obtain a white diPMCD solid; dissolving the diPMCD and the manganese porphyrin into water and mixing uniformly; and adding sodium ascorbate to obtain a target object. The preparation method has the advantage of being is simple and the components have relatively strong bonding capability; the super-molecular nano fiber can be effectively imaged in a body of a mouse and has a wide application prospect in the field of a magnetic resonance imaging contrast agent; and the invention provides a novel method for preparing the contrast agent.