Preparation of supramolecular dendritic nano aggregate for magnetic resonance imaging contrast

Abstract

The invention provides preparation of supramolecular dendritic nano aggregate for magnetic resonance imaging contrast. A construction unit utilizes bridged trimer full-methylated beta-cyclodextrin as a subject and utilizes manganese porphyrin as an object, and a supramolecular assembly is constructed through subject-object inclusion complexation interaction. The preparation method comprises the following steps: 1) dissolving 6-isothiocyano-6-deoxy-fully methylated beta-cyclodextrin and tri(2-aminoethyl) in acetonitrile under argon protection, stirring the solution at room temperature overnight, removing the solvent by rotary evaporating, purifying the residual solid through column chromatography to obtain faint yellow solid; and 2) dissolving the solid and manganese porphyrin in water, and uniformly mixing the ingredients, and adding sodium ascorbate to prepare the target object. The preparation method provided by the invention has the advantages that the ingredients of the supramolecular dendritic nano aggregate have strong bonding ability and can effectively improve the water relaxation ability, thereby having a broad application prospect in the field of magnetic resonance imaging contrast agents; and the preparation method is simple and is beneficial to realizing large-scale popularization and application.

Description

technical field [0001] The invention belongs to nano supramolecular materials, in particular to the preparation of supramolecular dendritic nano aggregates for magnetic resonance imaging contrast. Background technique [0002] Magnetic Resonance Imaging (Magnetic Resonance Imaging) is a new type of high-tech imaging examination method in recent years, which uses non-invasive radiation to obtain spatially and temporally resolved three-dimensional (3D) images of the entire living body. Although this new diagnostic technique was only used in clinical medicine in the early 1980s, it has no ionizing radiation (radiation) damage, no bony artifacts, and can be multi-directional (transverse, coronal, sagittal, etc.) With unique advantages such as multi-parameter imaging, high soft tissue resolution, and the ability to display vascular structures without the use of contrast agents, it has become the main means of diagnosis and monitoring of some diseases, see: 1) C. H. Polman, S. C....

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Problems solved by technology

However, the disadvantages of magnetic resonance imaging detection are low sensitivity, long detection time and high detection cost. Therefore, it is necessary to use magnetic resonance contrast agents to enhance and expand the application of magnetic resonance imaging in the field of molecular imaging. See: E. Terreno, D. D. Castelli, A. Viale, S. Aime. Chem. Rev. 2010,110, 3019?3042

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