Magnetic nanoparticle compound for T1 and T2 bimodal magnetic resonance contrast medium and preparation method thereof

A technology of magnetic nanoparticles and magnetic resonance contrast agents, which is applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agents, preparations for in vivo experiments, pharmaceutical formulations, etc., to enhance targeting, enhance T1 imaging effects, cells and tissues less toxic effect

Active Publication Date: 2017-07-07
WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Magnetic nanoparticle compound for T1 and T2 bimodal magnetic resonance contrast medium and preparation method thereof
  • Magnetic nanoparticle compound for T1 and T2 bimodal magnetic resonance contrast medium and preparation method thereof
  • Magnetic nanoparticle compound for T1 and T2 bimodal magnetic resonance contrast medium and preparation method thereof

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Embodiment 1

[0046] 1. Fe coated with oleic acid 3 o 4 Preparation of nanoparticles:

[0047] 1.1, 1.08g FeCl 3 ·6H 2 O, 3.65g of sodium oleate was dissolved in a mixed solvent of 8ml of ethanol, 6ml of distilled water and 14ml of hexane to obtain a mixed solution, the mixed solution was heated to 70°C and refluxed for 4h, after the reflux was completed, cooled to room temperature, layered and separated Obtain the upper organic layer, wash the organic layer 3 times with distilled water, and dry to obtain iron oleate;

[0048] 1.2. Weigh 1.8g iron oleate and 0.62g oleic acid into the Erlenmeyer flask, then add 10g trioctylamine, heat the Erlenmeyer flask to 340°C at a speed of 25°C / min under stirring, and keep stirring for 1h, then stir Then flow through the Erlenmeyer flask with a stream of nitrogen gas, the mixed product in the Erlenmeyer flask is cooled to room temperature, and the mixed product is precipitated with ethanol-hexane mixed solvent-redispersed (each purification uses eth...

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Abstract

The invention discloses a magnetic nanoparticle compound for a T1 and T2 bimodal magnetic resonance contrast medium and a preparation method thereof. The magnetic nanoparticle compound is of a three-layered core-shell structure. The cores are Fe3O4 nanoparticles, the middle layer is a silicon dioxide layer of manganese-porphyrin hydrochloride, and the outermost layer is an acrylic acid polymer layer of cyclopeptide radial-cRGD of a targeted integrin receptor. The preparation method comprises the following steps: 1, preparing OA@Fe3O4@nSiaO2@mSiO2; 2, preparing OA@Fe3O4@nSiO2@mSiO2@PAA-cRGD; 3, preparing manganese-porphyrin hydrochloride; and 4, preparing Mn-IOSP. The magnetic nanoparticle compound is used for preparing a new generation T1 and T2 bimodal magnetic resonance contrast medium which is high in relaxation rate, low in toxicity and long in circulating time. The magnetic nanoparticle compound can improve the imaging performance and accuracy, and has good biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of preparation of novel nuclear magnetic resonance contrast agents and tumor diagnosis and treatment imaging, and specifically relates to a method for T 1 , T 2 Magnetic nanoparticle composites of dual-modal magnetic resonance contrast agents and methods for their preparation. Background technique [0002] Magnetic resonance imaging (MRI) is considered to be one of the most effective means of disease diagnosis due to its inherent advantages of non-invasiveness, biological safety and high spatial resolution. In MRI, differences in proton density and turnover time affect relaxation rates, leading to MRI contrasts in which different biological tissues and organs exhibit characteristics. However, when the contrast effect between the target organ and the surrounding parts is not obvious, it is difficult to accurately detect the target area. MRI contrast agents can accelerate T at the target site 1 or T 2 Rel...

Claims

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Application Information

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IPC IPC(8): A61K49/14A61K49/08A61K49/18
CPCA61K49/08A61K49/14A61K49/183A61K49/1833A61K49/1866
Inventor 周欣黄曦陈世桢孙献平刘买利
Owner WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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