Medicine eutectic of ciprofloxacin and salicylic acid and preparation process thereof

A technology of ciprofloxacin and salicylic acid, which is applied in the field of drug co-crystals, can solve the problems of lack of double synergy, broad-spectrum antibacterial, and narrow application range of mandelic acid, so as to improve drug efficacy and bioavailability, High yield and reproducible results
CN103864683BActive Publication Date: 2015-07-01JIANGSU SENRAN CHEM
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU SENRAN CHEM
Publication Date
2015-07-01

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Abstract

The invention discloses a medicine eutectic of ciprofloxacin and salicylic acid and a preparation process thereof. The preparation method of the eutectic comprises the steps: adding ciprofloxacin and salicylic acid in an alcohol water solution or methane water solution, stirring, standing, filtering, naturally volatilizing filtrate at a room temperature, obtaining a solid-liquid mixture containing a colorless blocky crystal after 1-3 weeks, collecting the colorless blocky crystal after filtering, and drying to obtain the medicine eutectic of ciprofloxacin and salicylic acid. The invention further provides an industrialized rapid preparation method of the eutectic. The preparation method comprises the steps: adding ciprofloxacin and salicylic acid in the alcohol water solution, mixing, stirring, heating to 70-80 DEG C, reflowing for 2 hours, and stopping reaction after a reaction solution is clarified, filtering at a temperature of 70-80 DEG C, loading filtrate in a closed container, and standing for 6-24 hours at a room temperature to obtain the medicine eutectic of ciprofloxacin and salicylic acid. The method for synthesizing the medicine eutectic of ciprofloxacin and salicylic acid, disclosed by the invention, is low in equipment requirement, good in eutectic heat stability, and high in yield; and the industrialized production is easily realized.
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Description

technical field

[0001] The invention relates to the technical field of drug co-crystals, in particular to drug co-crystals of ciprofloxacin and salicylic acid and a preparation method thereof. technical background

[0002] Due to the importance of hydrogen bonding in crystal engineering, great efforts have been made in materials science, molecular recognition and biological entities, and pharmaceutical industries to understand the structure of hydrogen-bonded systems and to exploit them (G. R. Desiraju, Crystal Engineering: The Design of Organic Solids. Elsevier: New York, 1989; Shen Jiacong, Sun Junqi. Advances in Supramolecular Science Research. Chinese Academy of Sciences, 2004, 19, 420?424.). Over the past two decades, the crystalline form of active pharmaceutical ingredients has received increasing attention. It is generally accepted that crystalline forms of drugs include polymorphs, hydrates, solvates, salts, and co-crystals. The molecules of active pharmaceutical i...

Claims

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