Hemodialyzer and hematodialysis device

A hemodialysis and dialysate technology, applied in the field of medical devices, can solve the problems of biocompatibility and hemocompatibility, hydrophilicity, smoothness and low removal rate, and reduce the phenomenon of concentration polarization, blood Low residue and excellent biocompatibility

Active Publication Date: 2014-06-25
广东达爱斯医用科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Polyethersulfone hollow fiber membranes are used as dialysis membranes for hemodialyzers due to their excellent properties (such as high clearance of medium molecular solutes), but the biocompatibility and Blood compatibility, hydrophilicity, smoothness and removal rate are relatively low

Method used

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  • Hemodialyzer and hematodialysis device
  • Hemodialyzer and hematodialysis device
  • Hemodialyzer and hematodialysis device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Example 1 Preparation of polyethersulfone hollow fiber membrane 1

[0087] 1. Preparation of each component:

[0088] Hydroxy titanium dioxide mixture: mix 300g of 1-10nm water-soluble titanium dioxide with 700g of ethylene glycol, and stir at 45°C for 30 minutes under nitrogen protection to obtain a hydroxyl titanium dioxide mixture.

[0089] Modified polyethersulfone blend: mix 900g polyethersulfone P-3500, 100g polyvinylpyrrolidone k90, 0.05g sodium hydroxide and 0.5g sodium persulfate, and mix them under nitrogen protection at 95°C for 35 minutes to make each The components undergo a cross-linking reaction to prepare a modified polyethersulfone blend.

[0090] 2. Preparation of polyethersulfone hollow fiber membrane:

[0091] Add 300g of modified polyethersulfone blend, 90g of polyvinylpyrrolidone k90, 30g of nano-modified hydroxy titanium dioxide mixture and 70g of polyethylene glycol (2000) into dimethyl sulfoxide, and use dry-wet method at 60°C under nitrogen...

Embodiment 2

[0092] Example 2 Preparation of polyethersulfone hollow fiber membrane 2

[0093] 1. Preparation of each component:

[0094] Hydroxy titanium dioxide mixture: mix 255g of 1-10nm water-soluble titanium dioxide with 745g of ethylene glycol, and stir at 45°C for 30 minutes under nitrogen protection to obtain a hydroxyl titanium dioxide mixture.

[0095]Modified polyethersulfone blend: mix 980g polyethersulfone P-3500, 20g polyvinylpyrrolidone k90, 0.08g sodium hydroxide and 0.8g sodium persulfate, and mix under nitrogen protection at 100°C for 60 minutes to make each The components undergo a cross-linking reaction to prepare a modified polyethersulfone blend.

[0096] 2. Preparation of polyethersulfone hollow fiber membrane:

[0097] Add 280g of modified polyethersulfone blend, 70g of polyvinylpyrrolidone k90, 20g of nano-modified hydroxy titanium dioxide mixture and 90g of polyethylene glycol (1800) into dimethylacetamide, and adopt a dry-wet method at 60°C under nitrogen pr...

Embodiment 3

[0098] Example 3 Preparation of polyethersulfone hollow fiber membrane 3

[0099] 1. Preparation of each component:

[0100] Hydroxy titanium dioxide mixture: mix 200g of 1-10nm water-soluble titanium dioxide with 800g of ethylene glycol, and stir at 50°C for 30 minutes under nitrogen protection to obtain a hydroxyl titanium dioxide mixture.

[0101] Modified polyethersulfone blend: mix 950g polyethersulfone P-3500, 50g polyvinylpyrrolidone k90, 0.05g sodium hydroxide and 0.8g sodium persulfate, and mix under nitrogen protection at 95°C for 30 minutes to make each The components undergo a cross-linking reaction to prepare a modified polyethersulfone blend.

[0102] 2. Preparation of polyethersulfone hollow fiber membrane:

[0103] Add 320g of modified polyethersulfone blend, 120g of polyvinylpyrrolidone k90, 80g of nano-modified hydroxy titanium dioxide mixture and 50g of polyethylene glycol (2000) into dimethyl sulfoxide, and use dry-wet method at 80°C under nitrogen Sti...

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Abstract

Provided are a hemodialyzer and a hematodialysis device. The hemodialyzer comprises an outer shell, a fiber bundle formed by a hollow fiber pipe, an end cover, packaging glue, an annular flow guiding distribution ring, a dialyzate inlet, a dialyzate outlet, a blood inlet and a blood outlet. The annular flow guiding distribution ring is placed at the positions right opposite to the dialyzate inlet and/or the dialyzate outlet, one end of the annular flow guiding distribution ring is connected to the tail end of the outer shell, and the other end of the annular flow guiding distribution ring inclines in the longitudinal direction of the outer shell toward the dialyzate inlet or the dialyzate outlet right opposite to the annular flow guiding distribution ring. The hollow fiber pipe is made of a polyether sulfone hollow fiber film, and the spinning dope of the polyether sulfone hollow fiber film comprises, by weight, 250 parts-650 parts of modified polyether sulfone blends, 20 parts-400 parts of hydrophilia molecular compounds, 1 part-90 parts of nano-modification hydroxide radical titanium dioxide blends and 20 parts-120 parts of alcohols solvents. The hemodialyzer improves the contact area and the removal rate of dialyzate and the surface of the fiber pipe, and the high removal rate and the high ultrafiltration coefficient are achieved.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a hemodialyzer and a hemodialysis device. Background technique [0002] Hemodialyzers are mainly used for hemodialysis and blood filtration in the treatment of kidney diseases. The structure of existing hemodialyzer mainly comprises: shell, the fiber bundle that is made up of fiber silk tube, encapsulant, end cover, dialysate inlet, dialysate outlet, blood inlet, blood outlet and be positioned at dialysate inlet and outlet. The liquid blocking plate, wherein the fiber bundle is put into the shell, the dialysate inlet and the blood outlet are located at one end of the shell, and the dialysate outlet and the blood inlet are located at the other end of the shell, the two ends of the fiber bundle are sealed with sealing glue, and the liquid blocking plate is respectively located at The two ends of the housing are facing the dialysate inlet and the dialysate outle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/18
CPCA61M1/16B01D69/08B01D71/68
Inventor 韩全张恒
Owner 广东达爱斯医用科技有限公司
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