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Application of poly-dopamine nano-particles

A nanoparticle, polydopamine technology, applied in the application field of polydopamine nanoparticles, can solve the problems of difficult to obtain imaging effect, weak absorption, etc.

Inactive Publication Date: 2014-07-09
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, it also has optical and magnetic properties, and is also used for magnetic resonance imaging and photoacoustic imaging, but its absorption in the near-infrared region is weak when it is used as a photoacoustic imaging contrast agent, and it is difficult to obtain good imaging effects

Method used

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  • Application of poly-dopamine nano-particles
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  • Application of poly-dopamine nano-particles

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preparation example Construction

[0053] The present invention has no special limitation on the source of the polydopamine nanoparticles, and the polydopamine nanoparticles well-known to those skilled in the art can be used. For example, commercially available products can be used, or polydopamine nano-particles well-known to those skilled in the art can be used. The technical scheme of the particles is self-prepared. Specifically, in the present invention, the preparation method of the polydopamine nanoparticles preferably comprises the following steps:

[0054] performing oxidative polymerization reaction of dopamine hydrochloride in a mixed solvent to obtain polydopamine nanoparticles;

[0055] The mixed solvent includes water, alcohol compound and ammonia water.

[0056] In the present invention, there is no special limitation on the order of mixing the dopamine hydrochloride and the mixed solvent, preferably, dopamine hydrochloride is added to the mixed solvent. In the present invention, the dopamine hy...

Embodiment 1

[0085] Put 20mL of ethanol, 45mL of deionized water and 1mL of ammonia water with a mass fraction of 25% in a 100mL reaction flask, and stir at 30°C for 30min to obtain a mixed solvent;

[0086] Dissolve 0.2528g of dopamine hydrochloride in 5mL of deionized water, then add the aqueous solution of dopamine hydrochloride into the above mixed solvent, avoid light, stir at 30°C, and carry out oxidative polymerization reaction for 24 hours, the reaction system gradually changes from colorless to It is light brown, and finally turns black. The obtained product is subjected to high-speed centrifugation and washed with deionized water three times to obtain polydopamine nanoparticles.

[0087] The present invention carries out transmission electron microscope analysis to the obtained polydopamine nanoparticle, the result is as follows figure 1 as shown, figure 1 It is a transmission electron microscope image of the polydopamine nanoparticles obtained in Example 1 of the present invent...

Embodiment 2

[0097] Put 20mL of ethanol, 45mL of deionized water and 1.5mL of ammonia water with a mass fraction of 28% in a 100mL reaction flask, and stir at 30°C for 30min to obtain a mixed solvent;

[0098] Dissolve 0.2510g of dopamine hydrochloride in 5mL of deionized water, then add the aqueous solution of dopamine hydrochloride into the above mixed solvent, keep away from light, stir at 30°C, carry out oxidative polymerization for 24 hours, the reaction system gradually changes from colorless to It is light brown, and finally turns black. The obtained product is subjected to high-speed centrifugation and washed with deionized water three times to obtain polydopamine nanoparticles.

[0099] The present invention carries out transmission electron microscope observation to polydopamine nanoparticle, and observation result is as follows: Figure 9 as shown, Figure 9 It is a transmission electron microscope image of the polydopamine nanoparticles prepared in Example 2 of the present inv...

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Abstract

The invention provides an application of poly-dopamine nano-particles. By researches, the inventor discovers that the poly-dopamine nano-particles have strong absorbability in the near-infrared area, and have an excellent imaging effect when being used as a photoacoustic imaging contrast agent. Experiment results indicate that the poly-dopamine nano-particles have strong photoacoustic signals, high photoacoustic imaging contrast degree and clear images.

Description

technical field [0001] The invention relates to the field of photoacoustic imaging contrast agents, in particular to the application of polydopamine nanoparticles. Background technique [0002] Photoacoustic imaging is a non-destructive medical imaging method developed in recent years. It is a mixed-mode imaging method based on the photoacoustic effect, which combines the high contrast of pure optical imaging and the high penetration of pure ultrasound imaging. Acoustic imaging, which can obtain high-resolution and high-contrast tissue imaging. Recent studies have confirmed that photoacoustic imaging can be used in many life and medical fields such as the detection of tumor neovascularization, blood oxygen saturation scanning, brain functional imaging, and skin melanoma detection. [0003] Currently, in the field of imaging, photoacoustic imaging uses a thermoelastic expansion mechanism. The photoacoustic imaging process based on the thermoelastic mechanism refers to: when...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
Inventor 汤朝晖李明强林坚宋万通陈学思
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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