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Medicinal modified starch type blank pellet

A blank ball core and starch technology, which is applied in the direction of pharmaceutical formula, medical preparations of non-active ingredients, block transportation, etc., can solve the problems of poor roundness and brittleness of the ball core, and achieve roundness and brittleness. The effect of improved fragmentation and good market application prospects

Active Publication Date: 2014-07-16
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, the above-mentioned prior art still has the defects of poor roundness and friability of the ball core. We were pleasantly surprised to find that a combination of pregelatinized hydroxypropyl starch and cross-linked starch in a specific proportion was selected as the ball core. The main material of modified starch can solve the above problems. Therefore, the technical problem solved by the present invention is to provide a new type of blank ball core, which enhances the roundness of the ball core and improves its friability through some special properties of modified starch. , there will be no corrosion and collapse in the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Pregelatinized hydroxypropyl starch: 50kg

[0025] Medicinal sucrose: 8kg

[0026] Purified water: 5kg

[0027] The medicinal sucrose (50kg) was pulverized in a pulverizer, and the obtained granules were passed through an 80 sieve. Get 3kg of pulverized sucrose and mix evenly with 40kg of pregelatinized hydroxypropyl starch. Dissolve the remaining sucrose with purified water, pass the solution through an 80-mesh sieve, and set aside. The well-mixed sucrose and pregelatinized hydroxypropyl starch are added to the rotating host at a rotation speed of 200 rpm, and then sprayed into the prepared sucrose solution at a speed of 12 rpm. The air source pressure is 0.7MPa. During the granulation process, the remaining amount of pregelatinized hydroxypropyl starch (10 kg) was added. After 45 minutes of granulation in the main machine, it is out of the pot.

[0028] The produced granules were blast-dried at 80°C. Dried until the water content of the granules is less than...

Embodiment 2

[0030] Wheat cross-linked starch: 50kg

[0031] Medicinal sucrose: 8kg

[0032] Purified water: 5kg

[0033] The medicinal sucrose (8kg) was pulverized in a pulverizer, and the obtained granules were passed through an 80 sieve. Get 3kg of pulverized sucrose and mix evenly with 40kg of wheat cross-linked starch. Dissolve the remaining sucrose with purified water, pass the solution through an 80-mesh sieve, and set aside. The well-mixed sucrose and wheat cross-linked starch are added to the rotating host at a rotation speed of 200 rpm, and then the prepared sucrose solution is sprayed in at a speed of 12 rpm. is 0.7MPa. During the granulation process, the remaining amount of wheat cross-linked starch was added. After 50 minutes of granulation in the main machine, it is out of the pot.

[0034] The produced granules were blast-dried at 80°C. Dried until the water content of the granules is less than 4%, and then out of the pan. The pellets out of the pan are screened with...

Embodiment 3

[0036]Corn cross-linked starch: 50kg

[0037] Medicinal sucrose: 8kg

[0038] Purified water: 5kg

[0039] The medicinal sucrose (8kg) was pulverized in a pulverizer, and the obtained granules were passed through an 80 sieve. Get 3kg of pulverized sucrose and mix evenly with 40kg of corn cross-linked starch. Dissolve the remaining sucrose with purified water, pass the solution through an 80-mesh sieve, and set aside. The well-mixed sucrose and corn cross-linked starch are added to the rotating host at a rotation speed of 200 rpm, and then the prepared sucrose solution is sprayed in at a speed of 12 rpm. is 0.7MPa. During the granulation process, the remaining amount of corn cross-linked starch was added. After 52 minutes of granulation in the main machine, it is out of the pot.

[0040] The produced granules were blast-dried at 80°C. Dried until the water content of the granules is less than 4%, and then out of the pan. The pellets out of the pan are screened with a si...

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Abstract

The invention provides a medicinal modified starch type blank pellet, which is prepared from modified starch, saccharose and the like. The starch modification material serves as a main material. The medicinal modified starch type blank pellet is characterized by comprising the main material, an adhesive and solvent, wherein the main material is pregelatinized hydroxypropylated starch. The roundness of the prepared blank pellet is enhanced, and the friability of the blank pellet can be improved.

Description

technical field [0001] The invention relates to a sucrose-modified starch type medicinal blank core and a preparation method thereof, and relates to the field of medicine manufacture. Background technique [0002] Oral sustained and controlled release drug delivery system is one of the research hotspots in release pharmacy. The sustained and controlled release drug delivery system has the characteristics of stable, reliable and uniform drug release behavior. The sustained and controlled release drug delivery system uses different coating structures to endow the drug pellets with functions such as positioning in the human body and slow and controlled release, which reduces the stimulation of the drug to the gastrointestinal tract and avoids the phenomenon of sudden dose release. The duration of action and reduce the frequency of taking the drug. The characteristics of the sustained and controlled release system improve the effectiveness and safety of clinical medication. ...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K9/16
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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