Medicinal modified starch type blank pellet

A blank ball core and starch technology, which is applied in the direction of pharmaceutical formula, medical preparations of non-active ingredients, block transportation, etc., can solve the problems of poor roundness and brittleness of the ball core, and achieve roundness and brittleness. The effect of improved fragmentation and good market application prospects

Active Publication Date: 2014-07-16
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, the above-mentioned prior art still has the defects of poor roundness and friability of the ball core. We were pleasantly surprised to find that a combination of pregelatinized hydroxypropyl starch and cross-linked starch in a specific proportion was selected as the ball core. The main material of modified s

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0023] Example 1:

[0024] Pregelatinized hydroxypropyl starch: 50kg

[0025] Medicinal sucrose: 8kg

[0026] Purified water: 5kg

[0027] The medicinal sucrose (50kg) is crushed in a pulverizer, and the resulting granules are passed through 80 meshes. Take 3kg of crushed sucrose and 40kg of pregelatinized hydroxypropyl starch and mix them evenly. The remaining sucrose is dissolved in purified water, and the solution is passed through an 80-mesh sieve for use. The well-mixed sucrose and pregelatinized hydroxypropyl starch are added to the rotating host at a speed of 200 revolutions per minute, and then sprayed into the above-prepared sucrose solution at a speed of 12 revolutions per minute. The air source pressure is 0.7MPa. Add the remaining amount of pregelatinized hydroxypropyl starch (10kg) during the granulation process. After 45 minutes of granulating in the main machine, it is out of the pot.

[0028] The pellets were dried at 80°C by blowing air. After drying until the...

Example Embodiment

[0029] Example 2:

[0030] Wheat cross-linked starch: 50kg

[0031] Medicinal sucrose: 8kg

[0032] Purified water: 5kg

[0033] The medicinal sucrose (8kg) is pulverized in a pulverizer, and the obtained particles are passed through 80 mesh. Take 3 kg of crushed sucrose and 40 kg of wheat cross-linked starch and mix uniformly. The remaining sucrose is dissolved in purified water, and the solution is passed through an 80-mesh sieve for use. The well-mixed sucrose and wheat cross-linked starch are added to the rotating host at a speed of 200 revolutions per minute, and then sprayed into the above-prepared sucrose solution, the spraying speed is 12 revolutions per minute, and the air pressure It is 0.7MPa. During the granulation process, add the remaining amount of cross-linked wheat starch. After 50 minutes of granulating in the host, it is out of the pot.

[0034] The pellets were dried at 80°C by blowing air. After drying until the water content of the particles is lower than 4%...

Example Embodiment

[0035] Example 3:

[0036] Corn cross-linked starch: 50kg

[0037] Medicinal sucrose: 8kg

[0038] Purified water: 5kg

[0039] The medicinal sucrose (8kg) is pulverized in a pulverizer, and the obtained particles are passed through 80 mesh. Take 3 kg of crushed sucrose and 40 kg of corn cross-linked starch and mix them evenly. The remaining sucrose is dissolved in purified water, and the solution is passed through an 80-mesh sieve for use. The well-mixed sucrose and corn cross-linked starch are added to the rotating host at a speed of 200 revolutions per minute, and then sprayed into the above-prepared sucrose solution at a speed of 12 revolutions per minute and air pressure It is 0.7MPa. The remaining amount of corn cross-linked starch is added during the pelleting process. After 52 minutes of granulating in the main machine, it is out of the pot.

[0040] The pellets were dried at 80°C by blowing air. After drying until the water content of the particles is lower than 4%, they...

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PUM

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Abstract

The invention provides a medicinal modified starch type blank pellet, which is prepared from modified starch, saccharose and the like. The starch modification material serves as a main material. The medicinal modified starch type blank pellet is characterized by comprising the main material, an adhesive and solvent, wherein the main material is pregelatinized hydroxypropylated starch. The roundness of the prepared blank pellet is enhanced, and the friability of the blank pellet can be improved.

Description

technical field [0001] The invention relates to a sucrose-modified starch type medicinal blank core and a preparation method thereof, and relates to the field of medicine manufacture. Background technique [0002] Oral sustained and controlled release drug delivery system is one of the research hotspots in release pharmacy. The sustained and controlled release drug delivery system has the characteristics of stable, reliable and uniform drug release behavior. The sustained and controlled release drug delivery system uses different coating structures to endow the drug pellets with functions such as positioning in the human body and slow and controlled release, which reduces the stimulation of the drug to the gastrointestinal tract and avoids the phenomenon of sudden dose release. The duration of action and reduce the frequency of taking the drug. The characteristics of the sustained and controlled release system improve the effectiveness and safety of clinical medication. ...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K9/16
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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