Adenine synthesis technology

A synthesis process and adenine technology, applied in the field of adenine synthesis technology, can solve the problems of large amount of three wastes treatment, many reaction steps, low yield and the like, and achieve the effects of improving production efficiency, reducing processing cost and simple process

Inactive Publication Date: 2014-07-16
XINXIANG RUICHENG TECH DEV
View PDF0 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to being prepared by the total synthesis of diethyl malonate, the current industrial production of adenine in domestic manufacturers is based on hypoxanthine as a starting material, which is mixed wi

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0007] Example 1,

[0008] First add 110 parts by weight of acetic anhydride to the dry reaction kettle, and at the same time turn on the stirring, slowly add 38 parts by weight of adenosine, heat to 110°C with a jacket, and use the residual temperature of the jacket to dissolve the adenosine. After cleaning, add 2.5 parts by weight of boric acid, keep the reaction at 110°C, and the reaction solution will gradually become turbid after 1.5 hours. Continue the reaction at 110°C for 10 hours and then cool down overnight; (2) Separate the reaction solution by suction, and the filter cake is Acetyl adenine, dried for later use; (3) The mother liquor in step (2) is concentrated by negative pressure to dry the mixture of acetic acid and acetic anhydride, and the obtained syrup is added to the pre-prepared reaction kettle with a measured 100 weight After aliquots of water, the syrup was pumped into the kettle, washed with water, cooled to 20°C to crystallize, and filtered to obtain crude...

Example Embodiment

[0009] Example 2,

[0010] First add the measured 115 parts by weight of acetic anhydride into the dry reaction kettle, and at the same time turn on the stirring, slowly add 39 parts by weight of adenosine, heat it to 110°C with a jacket, and use the residual temperature of the jacket to dissolve the adenosine. After cleaning, add 3 parts by weight of boric acid and keep the reaction at 115°C. After 2 hours, the reaction solution will gradually become turbid. Continue the reaction at 115°C for 10 hours and then cool down overnight; (2) Separate the reaction solution by suction and filter cake. Acetyl adenine, dried for later use; (3) The mother liquor in step (2) is concentrated by negative pressure to dry the mixture of acetic acid and acetic anhydride, and the resulting syrup is added to the pre-prepared reaction kettle with a measured weight of 105 After aliquots of water, the syrup was pumped into the kettle, washed with water, cooled to 20°C to crystallize, and filtered to o...

Example Embodiment

[0011] Example 3,

[0012] First add the measured 120 parts by weight of acetic anhydride into the dry reaction kettle, and at the same time turn on the stirring, slowly add 40 parts by weight of adenosine, heat it to 110°C with a jacket, and use the residual temperature of the jacket to dissolve the adenosine. After cleaning, add 3.5 parts by weight of boric acid and keep the reaction at 113°C. After 2.5 hours, the reaction solution will gradually become turbid. Continue the reaction at 112°C for 10 hours and then cool down overnight; (2) Separate the reaction solution by suction and filter cake. Acetyl adenine, dried for later use; (3) The mother liquor in step (2) is concentrated by negative pressure to dry the mixture of acetic acid and acetic anhydride, and the resulting syrup is added to the pre-prepared reaction kettle with a measured 110 weight After aliquots of water, the syrup was pumped into the kettle, washed with water, cooled to 20°C to crystallize, and filtered to ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an adenine synthesis technology. The adenine synthesis technology comprises the following steps: acetylating adenosine serving as a substrate by using acetic anhydride so as to obtain acetylated adenine and tetraacetylribose, carrying out alkaline hydrolysis on the acetylated adenine, and neutralizing the acetylated adenine so as to obtain adenine. The adenine synthesis technology is simple, very beneficial to the large-scale production of the adenine and capable of greatly reducing the processing cost of the adenine and improving the production efficiency of the adenine.

Description

Technical field: [0001] The invention relates to the manufacture of adenine, in particular to an adenine synthesis process. Background technique: [0002] Adenine, whose chemical name is 6-aminopurine, is the main raw material for the synthesis of vitamin B4. Every year, hundreds of tons of adenine are exported to the international market for the preparation of purine derivatives and other drugs. In addition to being prepared by the total synthesis of diethyl malonate, the current industrial production of adenine in domestic manufacturers is based on hypoxanthine as a starting material, which is mixed with phosphorus oxychloride and N,N-dimethylaniline. Chlorination, hydrolysis, pressurized ammoniation, refining and other reaction synthesis, many reaction steps, low yield, large amount of three wastes treatment. Invention content: [0003] The purpose of the present invention is to provide an adenine synthesis process with simple process and favorable for large-sc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D473/34
CPCC07D473/34
Inventor 张成立
Owner XINXIANG RUICHENG TECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap