Illumination-magnesium ion double-crosslinking alginate hydrogel and preparation method thereof

A technology of alginate and hydrogel, which is applied in the field of biomedicine, can solve the problems of poor biological activity and poor stability of photocrosslinked alginate hydrogel, and achieve improved mechanical strength, enhanced adhesion, and improved biological properties Effect

Active Publication Date: 2014-07-16
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The present invention provides a stable Illumination-magnesium ion double cross-linked alginate hydrogel with property, controllability and biological activity and preparation method thereof

Method used

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  • Illumination-magnesium ion double-crosslinking alginate hydrogel and preparation method thereof
  • Illumination-magnesium ion double-crosslinking alginate hydrogel and preparation method thereof
  • Illumination-magnesium ion double-crosslinking alginate hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (2) Preparation of Mg-100 gel precursor solution: Dissolve photocrosslinkable alginate at a ratio of 2.5% (w / v) in deionized water containing 0.0625% (w / v) photoinitiator I2959 ; Prepare MgSO with a concentration of 500 mmol / L 4 solution, MgSO 4 The solution was uniformly mixed with the above alginate solution at a volume ratio of 1:4 to obtain a gel precursor solution. The concentration of each component was as follows: photocrosslinkable alginate, 2% (w / v); I2959, 0.05% (w / v); MgSO 4 , 100 mmol / L.

[0034] (3) Drop the gel precursor solution into the mold, let it stand for 30 min, and then place it under a wavelength of 365 nm and an intensity of 8 mW / cm 2 The light-magnesium ion double-crosslinked alginate hydrogel (Mg-100) was obtained by irradiating under the ultraviolet lamp for 10 min. Its operation diagram is as figure 1 shown.

[0035] The carbon-carbon double bonds grafted on MA were broken under the joint action of ultraviolet rays and photoinitiators,...

Embodiment 2

[0038] (2) Drop the gel precursor solution into the mold, let it stand for 30 min, and then place it under a wavelength of 365 nm and an intensity of 8 mW / cm 2 The light-magnesium ion double cross-linked alginate hydrogel (Mg-1) was obtained by irradiating under the ultraviolet lamp for 10 min.

[0039] Example 3

Embodiment 3

[0041] (2) Drop the gel precursor solution into the mold, let it stand for 30 min, and then place it under a wavelength of 365 nm and an intensity of 8 mW / cm 2 The light-magnesium ion double-crosslinked alginate hydrogel (Mg-10) was obtained by irradiating under the ultraviolet lamp for 10 min.

[0042] Performance Testing

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Abstract

The invention discloses an illumination-magnesium ion double-crosslinking alginate hydrogel and a preparation method thereof. The illumination-magnesium ion double-crosslinking alginate hydrogel can be prepared by preparing a precursor solution via an alginate solution with photo-crosslinking function, a photoinitiator and magnesium ions with bioactivity and carrying out of ionic reaction and ultraviolet illumination double-crosslinking reaction. According to the illumination-magnesium ion double-crosslinking alginate hydrogel and the preparation method thereof, the magnesium ions are imported into a bracket through an ion crosslinking manner, so that the biological characteristic of the bracket is simply and effectively improved; at the same time, a main framework is formed through photo-crosslinking, so that the stability of the bracket is ensured; and through ultraviolet initiation and the slow crosslinking characteristic of the magnesium ions, the favorable controllability of the bracket is ensured. The preparation method is simple and does not need to import other materials; and through controlling the concentration of the magnesium ions, the physical and chemical properties and the biological property of the hydrogel can be effectively adjusted and convenience is brought to the practical application.

Description

[0001] technical field [0002] The invention belongs to the field of biomedicine, and relates to an alginate hydrogel and a preparation method thereof, in particular to an illumination-magnesium ion double-crosslinked alginate hydrogel and a preparation method thereof. Background technique [0003] Bone defects caused by trauma, tumors, infections, and abnormal development have always been a difficult point in clinical treatment. Bone transplantation is the main method for reconstructing defective bone tissue, but when using autologous bone transplantation, the source of autologous bone is less, and it will bring some pain to the patient; when using allogeneic bone transplantation, there are problems such as infection and rejection. The development of tissue engineering provides a new way of thinking for the development of ideal bone grafts. Scaffold is one of the three elements of bone tissue engineering. In addition to non-toxicity, non-immunogenicity, degradability and...

Claims

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Application Information

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IPC IPC(8): C08B37/04C08J3/28C08J3/24
Inventor 王家伟尹苗徐飞邓婷
Owner WUHAN UNIV
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