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Use of rhizoma bletillae ethyl acetate extract

A technology of ethyl acetate extraction and ethyl acetate, which is applied in the direction of medical preparations containing active ingredients, plant raw materials, plant/algae/fungus/moss components, etc., to achieve good inhibitory effect and protect individual from bacterial infection

Inactive Publication Date: 2014-07-23
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Through literature search, it is found that current pharmacological research mainly focuses on whitening and hemostatic effects, and there are few reports on antibacterial activity in China.

Method used

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  • Use of rhizoma bletillae ethyl acetate extract
  • Use of rhizoma bletillae ethyl acetate extract
  • Use of rhizoma bletillae ethyl acetate extract

Examples

Experimental program
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Effect test

Embodiment 1

[0020] The preparation method of embodiment 1 white and ethyl acetate extract

[0021] Weigh 250g of Baiji medicinal material, pulverize, add 95% v / v ethanol to heat and reflux to extract twice, the first time is 10 times the amount, the second time is 8 times the amount, each time for 1 hour. The two extracts were combined, filtered, and the solvent was recovered from the filtrate under reduced pressure to obtain 31 g of crude extract. Take the crude extract, add about 250ml of water, ultrasonically suspend, transfer to a 1000ml separatory funnel, add petroleum ether to extract 8 times, 300ml each time, and extract the remaining water layer with ethyl acetate 10 times, 250ml each time, reduce Ethyl acetate was recovered under pressure to obtain 8 g of ethyl acetate extract.

Embodiment 2

[0022] The preparation method of embodiment 2 white and ethyl acetate extract

[0023] Weigh 500g of Baiji medicinal material, pulverize it, add 80% v / v ethanol to heat and reflux to extract twice, the first time is 10 times the amount, the second time is 8 times the amount, each time for 1 hour. The two extracts were combined, filtered, and the solvent was recovered from the filtrate under reduced pressure to obtain a crude extract. Take the crude extract, after drying, add petroleum ether and shake and extract for 5 times, then shake and extract the remaining water layer with ethyl acetate for 5 times, combine the parts of ethyl acetate, recover ethyl acetate under reduced pressure, and obtain ethyl acetate for extraction thing.

Embodiment 3

[0024] The preparation method of embodiment 3 white and ethyl acetate extract

[0025] Weigh 100g of Baiji medicinal material, pulverize it, add 90% v / v ethanol to heat and reflux to extract twice, the first time is 12 times the amount, the second time is 10 times the amount, each time for 1 hour. The two extracts were combined, filtered, and the solvent was recovered from the filtrate under reduced pressure to obtain a crude extract. Take the crude extract, dry it, add petroleum ether and soak it warmly for 3 times, and soak the remaining water layer with ethyl acetate for 5 times, combine the ethyl acetate parts, recover the ethyl acetate under reduced pressure, and obtain the ethyl acetate extract.

[0026] The beneficial effects of the present invention are illustrated below through test examples.

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Abstract

The invention provides use of a rhizoma bletillae ethyl acetate extract in preparing anti-clinical drug-resistance bacteria drugs. The rhizoma bletillae ethyl acetate extract has a good inhibiting effect to various Gram negative bacteria, Gram positive bacteria and drug-resistance bacteria and can effectively protect bacteria infected individuals. The pharmacodynamics activity of the extract is equivalent to that of antibiotics. In particular, the extract can further effectively resist methicillin-resistant staphylococcus aureus, thereby providing a better choice for clinical medication.

Description

[0001] This application is a divisional application of the patent application with application number: 201210590325.0. The filing date of the original application: December 31, 2012, the name of the invention: the use of white and ethyl acetate extracts. technical field [0002] The present invention relates to the new application of the extract of white and ethyl acetate. Background technique [0003] Infectious diseases have always been regarded as extremely dangerous diseases. It was not until Alexander Fleming accidentally discovered penicillin in 1928 and used it clinically that human beings had a major breakthrough in the fight against infectious diseases. However, with the widespread use of antibiotics, the harm of overuse of antibiotics is far beyond people's imagination: Jevons in the United Kingdom discovered methicillin-resistant Staphylococcus aureus (MRSA) for the first time. One of the important pathogens of infection. Studies have found that, in addition to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P31/04
Inventor 彭成万峰彭芙熊亮曹小玉
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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