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A kind of glutathione anticancer composition

A technology of glutathione and composition, which is applied in the field of glutathione anticancer composition, and can solve problems such as applications that have not been reported

Active Publication Date: 2016-01-20
潘宏涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] At present, there is no report on the application of combining Chinese herbal medicine and glutathione in the treatment of cancer

Method used

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  • A kind of glutathione anticancer composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, the preparation of Chinese medicine extract

[0027] Heat and extract 100g of Salvia miltiorrhiza, 100g of Sanqi, 50g of Atractylodes macrocephala, 20g of Fangfeng, 10g of dodder and 10g of horsetail with 80% ethanol by volume, combine the extracts, filter, and concentrate the filtrate to a clear paste; add ethanol to make the alcohol content reach 70% , standing for 24 hours, filtered, and the filtrate was concentrated under reduced pressure to recover ethanol to obtain the extract.

Embodiment 2

[0028] Embodiment 2, the preparation of tablet

[0029] Get 10g of the extract prepared by the method of Example 1, add reduced glutathione 10g, and sodium carboxymethyl starch 50g, microcrystalline cellulose 45g, lactose 35g, citric acid 3g, micronized silica gel 8g, magnesium stearate 3g, 10g of talcum powder, fully stirred and mixed to form granules, dried at 60°C for 4 hours, and pressed into 1000 pieces.

Embodiment 3

[0030] Example 3, Application of Compositions Comprising Chinese Medicine Extracts and Glutathione in Inhibiting Tumor Cell Growth

[0031] The tumor cells (human liver cancer BEL-7402 cells, human colon cancer HCT-8 cells, human lung cancer A-549 cells, human breast cancer MDA-MB-231 cells and human prostate cancer LNCaP cells) were digested with 0.25% trypsin, Then suspend the cells with DMEM complete medium containing 10% (volume percentage) fetal bovine serum to make a cell suspension, and dilute each tumor cell to 1.0×105 cells / mL, and inoculate them into 96 wells In the culture plate, 200 μL per well, each tumor cell was inoculated into 3 wells, at 37°C, 5% CO 2 Cultivate in an incubator for 24 hours; then pour out the culture solution in each well.

[0032] Get appropriate amount of the Chinese medicine extract that embodiment 1 makes and dissolve in ethanol, then dilute with DMEM complete medium, obtain Chinese medicine extract solution, make the final concentration o...

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Abstract

The invention relates to a composition containing glutathione. The composition comprises glutathione and traditional Chinese medicine extract, wherein the traditional Chinese medicine extract is prepared from 10 weight parts of salviae miltiorrhizae, 10 weight parts of pseudo-ginseng, 5 weight parts of white atractylodes rhizome, 2 weight parts of divaricate saposhnikovia root, 1 weight part of seed of Chinese dodder and 1 weight part of thalictrum glandulosissimum. The composition disclosed by the invention has application of treating cancers.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a glutathione anticancer composition and its application. Background technique [0002] Survival and recovery rates for cancer patients have improved with the development of chemotherapy. However, anticancer agents have the disadvantages of high toxicity and harm to normal cells. In order to overcome the above-mentioned side effects, many studies have recently been conducted to develop alternative anticancer substances and selectively inhibit the proliferation of tumor cells, thus obtaining many drug candidates with anticancer activity. However, the newly developed anticancer compounds that can specifically inhibit the proliferation of tumor cells are obtained through chemical synthesis, so they may have serious side effects in vivo. [0003] The disadvantages of traditional anticancer agents have prompted many researchers to devote themselves to the development of anticancer substance...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/06A61P35/00A61K36/71
Inventor 潘宏涛
Owner 潘宏涛
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