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Preparation method of polypeptide-polylactic-co-glycolic acid-polyvinylpyrrolidone double-grafted copolymer

A technology of polyvinylpyrrolidone and polylactic acid glycolic acid, which is applied in the field of biodegradable polymer material preparation, and achieves the effect that the preparation method is simple and easy to master

Inactive Publication Date: 2014-07-23
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, this double-graft copolymer has not been reported in the literature.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1) Synthesis of Polypeptide-poly(lactic-co-glycolic acid) graft copolymer

[0015] Add 8 grams of poly(r-benzyl-L-glutamate) with a molecular weight of 30,000, 4.2 grams of poly(lactic acid glycolic acid monododecyl ether) with a molecular weight of 1000, and 1.2 grams of p-toluenesulfonate in the dry reactor. acid, and then add 200 ml of 1,1,2-trichloroethane solvent, under an inert atmosphere, stir the reaction at 55°C for 3 days, terminate the reaction, and then obtain the target compound by filtration, dialysis, and drying.

[0016] 2) Synthesis of Polypeptide-PLGA-Polyvinylpyrrolidone Double Graft Copolymer:

[0017] Add 7 grams of polypeptide-poly(lactic-co-glycolic acid) graft copolymer, 1.6 grams of polyvinylpyrrolidone monododecyl ether with a molecular weight of 500 and 1.11 grams of p-toluenesulfonic acid into the drying reactor, and then add 140 milliliters of 1,1 , 2-trichloroethane solvent, under an inert atmosphere, stirred and reacted at 55°C for 3 days...

Embodiment 2

[0020] 1) Synthesis of Polypeptide-poly(lactic-co-glycolic acid) graft copolymer

[0021] Add 8 grams of poly(r-ethyl-L-glutamate) with a molecular weight of 40,000, 6.1 grams of poly(lactic acid glycolic acid monododecyl ether) with a molecular weight of 1500, and 1.3 grams of p-toluenesulfonic acid in the dry reactor. and 180 ml of dimethyl sulfoxide solvent, under an inert atmosphere, stirred and reacted at 56° C. for 2 days, terminated the reaction, and then filtered, dialyzed, and dried to obtain the target product.

[0022] 2) Synthesis of Polypeptide-PLGA-Polyvinylpyrrolidone Double Graft Copolymer:

[0023] Add 7 grams of polypeptide-polylactic-co-glycolic acid graft copolymer, 1.8 grams of polyvinylpyrrolidone monododecyl ether and 0.92 grams of p-toluenesulfonic acid with a molecular weight of 600, and then add 130 milliliters of dimethyl Sulfoxide solvent, under an inert atmosphere, stirred and reacted at 56°C for 2 days, terminated the reaction, and then filtered,...

Embodiment 3

[0026] 1) Synthesis of Polypeptide-poly(lactic-co-glycolic acid) graft copolymer

[0027] Add 9 grams of poly(r-methyl-L-glutamate) with a molecular weight of 50,000, 8.8 grams of poly(lactic acid glycolic acid monododecyl ether) with a molecular weight of 2000, and 1.35 grams of p-toluenesulfonic acid in the dry reactor. and 250 ml of 1,1,2-trichloroethane solvent, under an inert atmosphere, stirred and reacted at 58° C. for 3 days, terminated the reaction, and then obtained the target compound by filtration, dialysis, and drying.

[0028] 2) Synthesis of Polypeptide-PLGA-Polyvinylpyrrolidone Double Graft Copolymer

[0029] Add 8 grams of polypeptide-poly(lactic-co-glycolic acid) graft copolymer, 2.3 grams of polyvinylpyrrolidone monododecyl ether with a molecular weight of 700 and 1.06 grams of p-toluenesulfonic acid into the drying reactor, and then add 150 milliliters of 1,1 , 2-trichloroethane solvent, under an inert atmosphere, stirred and reacted at 58°C for 3 days, te...

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Abstract

The invention discloses a preparation method of a polypeptide-polylactic-co-glycolic acid-polyvinylpyrrolidone double-grafted copolymer. The preparation method comprises the following steps: 1) synthesizing a polypeptide-polylactic-co-glycolic acid grafted copolymer: adding a polypeptide homopolymer, polylactic-co-glycolic acid monododecylether, a solvent and a catalyst into a drying reactor, and performing stirring reaction at the temperature of 55-58 DEG C for 2-3 days under an inert atmosphere to obtain a target object; and 2) synthesizing the polypeptide-polylactic-co-glycolic acid-polyvinylpyrrolidone double-grafted copolymer: adding the polypeptide-polylactic-co-glycolic acid grafted copolymer, the catalyst, the solvent and the polyvinylpyrrolidone monododecylether into the drying reactor, and performing stirring reaction at the temperature of 55-58 DEG C for 2-3 days under the inert atmosphere to obtain the target object of the invention. The process of the invention is simple, and the obtained target object is a novel degradable biological material.

Description

technical field [0001] The invention relates to a preparation method of a polypeptide-polylactic acid glycolic acid-polyvinylpyrrolidone double graft copolymer, belonging to the technical field of biodegradable polymer material preparation. Background technique [0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability, which can be widely used in medicine as a carrier for the preparation of sustained-release drug systems; however, the polypeptide material is relatively hard and has poor hydrophilicity. As a result, its application is limited to a certain extent. Poly(D,L) lactic acid glycolic acid has good biocompatibility and biodegradability, and is relatively soft. Polyvinylpyrrolidone has excellent biocompatibility and biodegradability, and has good hydrophilicity. First graft the poly(lactic-co-glycolic acid) segment to the polypeptide molecular chain to obtain the polypeptide-poly(lactic-co-glycolic acid) graft copolymer, and then graft th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08G81/02
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH
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