Method for preparing antioxidant coated polymer nano-vesicle

An antioxidant and nanovesicle technology, applied in the field of skin beauty and health care chemicals, can solve the problems of no way to eliminate free radicals, skin damage, human body harm, etc. Effect

Inactive Publication Date: 2014-07-30
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing sunscreen products, both organic and inorganic, have major defects and are often harmful to the human body; inorganic products including titanium dioxide, zinc oxide or some other heavy metal oxides have strong photocatalytic capabilities, and these active ingredients will be released in the human body. The

Method used

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  • Method for preparing antioxidant coated polymer nano-vesicle
  • Method for preparing antioxidant coated polymer nano-vesicle
  • Method for preparing antioxidant coated polymer nano-vesicle

Examples

Experimental program
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Effect test

Embodiment 1

[0029] 0.5g macroinitiator PEO 43 -Br, 0.08g of catalyst ligand PMDETA, 0.8g of monomer DMA and 2ml of anhydrous methanol were added to the round bottom flask, macroinitiator PEO 43 The molar ratio of -Br, catalyst ligand PMDETA and monomer DMA is 1:1:20; Add 0.08g catalyst CuBr under the condition of anhydrous and oxygen-free; 43 The number of moles of -Br is the same. Atom transfer radical polymerization (ATRP) was carried out under the protection of argon or nitrogen, the reaction temperature was 25°C, and the reaction time was 8 hours. After the reaction, 3.9 g of monomeric styrene was dissolved in 10 ml of p-xylene, and added to the flask after deoxygenation. The reaction temperature was 60° C., and the reaction time was 50 hours. The prepared polymer is rotary evaporated, dissolved, passed through a neutral alumina column, precipitated, filtered, and vacuum-dried to obtain the amphiphilic block copolymer PEO 43 -b-PDMA 20 -b-PS 110 ; Wherein the mol ratio of styrene...

Embodiment 2

[0031] 0.5g macroinitiator PEO 43 -Br, 0.24g catalyst ligand PMDETA, 2.4g monomer DMA and 2ml anhydrous methanol were added to the round bottom flask, macroinitiator PEO 43 The molar ratio of -Br, catalyst ligand PMDETA and monomer DMA is 1:3:60; Add 0.08g catalyst CuBr under the condition of anhydrous and oxygen-free; 43 The number of moles of -Br is the same. Atom transfer radical polymerization (ATRP) was carried out under the protection of argon or nitrogen, the reaction temperature was 40°C, and the reaction time was 13 hours. After the reaction, 7.8 g of monomeric styrene was dissolved in 10 ml of p-xylene, and added to the flask after deoxygenation. The reaction temperature was 80° C., and the reaction time was 60 hours. The prepared polymer is rotary evaporated, dissolved, passed through a neutral alumina column, precipitated, filtered, and vacuum-dried to obtain the amphiphilic block copolymer PEO 43 -b-PDMA 60 -b-PS 220 ; Wherein the mol ratio of styrene and bro...

Embodiment 3

[0034] 0.5g macroinitiator PEO 43 -Br, 0.4g catalyst ligand PMDETA, 3.2g monomer DMA and 3ml anhydrous methanol were added to the round bottom flask, macroinitiator PEO 43 The molar ratio of -Br, catalyst ligand PMDETA and monomer DMA is 1:4:80; Add 0.08g catalyst CuBr under the condition of anhydrous and oxygen-free; 43 The number of moles of -Br is the same. Atom transfer radical polymerization (ATRP) was carried out under the protection of argon or nitrogen, the reaction temperature was 50°C, and the reaction time was 18 hours. After the reaction, 11.7 g of monomeric styrene was dissolved in 15 ml of p-xylene, and added to the flask after deoxygenation. The reaction temperature was 130° C., and the reaction time was 12 hours. The prepared polymer is rotary evaporated, dissolved, passed through a neutral alumina column, precipitated, filtered, and vacuum-dried to obtain the amphiphilic block copolymer PEO 43 -b-PDMA 80 -b-PS 340 ; Wherein the mol ratio of styrene and br...

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Abstract

The invention discloses a method for preparing an anti-oxidant coated polymer nano-vesicle. The method comprises the following steps: mixing bromo-polyoxyethylene, pentamethyldiethylenetriamine, dimethylaminoethyl methacrylate and a solvent in water-free and oxygen-free condition, adding cuprous bromide or cuprous chloride, and performing atom transfer radical polymerization in argon or nitrogen protection at 20-80 DEG C for 6-20 hours; dissolving styrene in anhydrous paraxylene, deoxidizing, and adding into the atom transfer radical polymerization to react at 40-130 DEG C for 12-72 hours; evaporating and dissolving the prepared polymer, passing the prepared through a neutral alumina column, precipitating, filtering and drying in vacuum to obtain an amphiphilic block copolymer PEO-b-PDMA-b-PS; dissolving the PEO-b-PDMA-b-PS and an antioxidant in THF (tetrahydrofuran), dripping deionized water or methanol which is 3-10 times of the THF at a speed of 1-60d/min under intense stirring; dialyzing in deionized water, and drying to obtain the product. The product obtained by the method can play a good health-care effect on skin, and can be used for delaying skin aging.

Description

technical field [0001] The invention belongs to the technical field of skin beauty and health care chemicals, and relates to a preparation method of a skin care product that can effectively delay skin aging, in particular to a preparation method of polymer nanovesicles coated with antioxidants. Background technique [0002] With the progress of the industrialization era, various toxic gases are discharged into the atmosphere, and the resulting environmental problems have become increasingly prominent; among them, the destruction of the ozone layer is a very prominent problem. Due to the destruction of the ozone layer, a large amount of ultraviolet rays pass through the atmosphere and directly irradiate the human skin. Excessive ultraviolet radiation not only causes great damage to people's skin, but also greatly increases the chance of suffering from skin cancer. Therefore, there are an endless stream of sunscreen products on the market, and these products mainly absorb or ...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K45/00A61K8/14A61K8/86A61K8/81A61K8/67A61K8/64A61K8/36A61K47/32A61K47/34C08F293/00C08F212/08C08F220/34A61P17/18A61Q17/04A61Q19/08A23L1/29A23P1/00A23L33/00A23P10/00
Inventor 杜建忠孙辉
Owner TONGJI UNIV
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