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Expandable saccule provided with modified coating on surface and preparation process of expandable saccule

A technology of modified coating and preparation process, applied in coatings, dilators, balloon-shaped catheters, etc., can solve the problems of high drug loss, low adhesion, limiting the efficacy of medical balloons, etc., to improve the prevention and treatment of restenosis. Effect

Active Publication Date: 2014-07-30
GUANGDONG BROSMED MEDICAL DEVICE CO LTD
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Problems solved by technology

However, the disadvantages of the existing drug-coated balloons are that the surface of the main body of the balloon is smooth, the adhesion between the balloon and the coating drug is small, and the drug loading rate is low. The scouring of the blood flow causes more loss of drugs in the blood during delivery, so that less effective drugs reach the target blood vessels, thus limiting the efficacy of medical balloons

Method used

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  • Expandable saccule provided with modified coating on surface and preparation process of expandable saccule
  • Expandable saccule provided with modified coating on surface and preparation process of expandable saccule
  • Expandable saccule provided with modified coating on surface and preparation process of expandable saccule

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Embodiment Construction

[0026] The present invention will be further described below in conjunction with accompanying drawing:

[0027] Such as Figure 1 to Figure 3 As shown, the technical scheme adopted by the present invention is as follows: a dilatable balloon with a modified coating on the surface is characterized in that: it includes a balloon body 1 and a modified coating 2, wherein the above-mentioned balloon body 1 is high Molecular material, the modified coating 2 is a water-insoluble polymer.

[0028] Preferably, the balloon body 1 is a nylon material or Pebax material well known to those skilled in the art. On the premise of not affecting the physical, chemical and mechanical properties of the balloon material, its surface is modified to make it rough, improving the For drug adhesion and loading rate.

[0029] Preferably, the water-insoluble polymer is a polymethacrylate compound monomer.

[0030] Preferably, the modified coating 2 has a thickness of 0.05-0.3 μm, preferably 0.1 μm.

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Abstract

The invention discloses an expandable saccule provided with a modified coating on the surface. The expandable saccule is characterized by comprising a saccule body and the modified coating, wherein the saccule body is a high-molecular material, and the modified coating is a water-insoluble high-molecular polymer. A preparation process of the expandable saccule provided with the modified coating on the surface is characterized by comprising the following steps: a, pretreatment of the surface of the saccule body; b, preparation of a coating solution; c, surface coating; d, UV light triggered polymerization; e, pore formation by washing of a solvent; f, low-temperature drying. During use, the expandable saccule disclosed by the invention can be used for ensuring a drug to be firmly adhered and loaded on the outer surface of a coating on the periphery of the saccule body and in pores of a porous structure of the saccule body, the initial drug loaded capacity is increased and drug loss during a conveying process of the saccule is reduced as well, so that enough drug is ensured to be released to diseased regions during an expansion process of the saccule, and thus the performances of preventing and treating lesions such as restenosis and intimal hyperplasia by expanding the saccule of blood vessels can be better improved.

Description

technical field [0001] The invention relates to a medical expansion balloon, in particular to an expansion balloon with a nanoscale / microscale honeycomb hole structure modified coating on the surface of the balloon and a preparation process thereof. Background technique [0002] The application of percutaneous coronary intervention (percutaneons coronary intervention, PCI) to implant stents in narrow coronary arteries is one of the most effective methods for revascularization of cardiovascular diseases. However, after the stent is implanted, due to the tearing of the intima by the expansion of the stent, the rupture of the atheromatous plaque in the lesion, and the outflow of atheromatous material, it may lead to secondary early acute and subacute thrombosis and late stent infarction. Restenosis has become a major problem that urgently needs to be solved in the treatment of percutaneous coronary intervention. [0003] The advent of drug-coated stents (durg eluting sent, DES...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14A61L31/10A61L31/14A61M25/10A61M29/02
Inventor 董超李斌刘艳宇张志军李诚王朝勇
Owner GUANGDONG BROSMED MEDICAL DEVICE CO LTD
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