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Application of rabdosia japonica in preparing anti-acute lung injury drugs

A technology for the preparation of anti-acute lung injury medicines for the preparation of the anti-acute lung injury of the blue calyx fragrant tea

Active Publication Date: 2014-08-20
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on whether or not the blue calyx fragrant tea has the effect of anti-acute lung injury. The present invention finds that it has the activity of anti-acute lung injury

Method used

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  • Application of rabdosia japonica in preparing anti-acute lung injury drugs
  • Application of rabdosia japonica in preparing anti-acute lung injury drugs
  • Application of rabdosia japonica in preparing anti-acute lung injury drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Anti-acute lung injury experiment of the ethanol extract (RJ) of the calyx calyx

[0034] 1. Experimental medicines and reagents: ethanol extract of Lemonia japonica; 0.5% sodium carboxymethylcellulose; lipopolysaccharide (LPS), Sigma-Aldrich Company of the United States; control drug, dexamethasone acetate tablets, Zhejiang Xianju Pharmaceutical Co., Ltd.; distilled water; normal saline; 20% urethane-normal saline; 4% formalin, H-E staining solution, etc.

[0035]2. Experimental mice: Kunming mice, male, weighing 24-28 grams, provided by the Experimental Animal Center of Soochow University, experimental animal production license: XCYK (Su) 2002-0008. The experimental animals were raised in an environment with a temperature of 24±1° C. and a relative humidity of 40% to 80%, with free access to food and water. Before the experiment, they were adaptively fed for 7 days.

[0036] 3. Other materials: ELISA kit, Shanghai Chuanfu Trading Co., Ltd.; nitric oxide (NO), BCA, s...

Embodiment 2

[0053] Anti-acute lung injury experiment of macroporous resin fractions (RJFs) of the ethanol extract of C.

[0054] The experimental drugs and reagents, experimental mice, other equipment, test methods and experimental data used in this example are all processed in the same manner as in Implementation 1. Among them, the ethanol extract (RJ) of R. japonica was changed to the macroporous resin fraction (RJFs) of the ethanol extract of R. japonica (RJFs), and the dosage of the control group was changed to 25.6mg / kg. The samples of large and medium The administration doses of the low-dose and low-dose groups were 6.4 mg / kg, 12.8 mg / kg, and 25.6 mg / kg, respectively.

[0055] After the experimental data was processed, the indicators for evaluating acute lung injury were compared among the experimental groups, and the results were as follows: Figure 10-18 shown.

[0056] From Figure 10-12 It can be seen that compared with the blank group, the W / D weight ratio, NO (nitric oxide)...

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Abstract

The invention discloses an application of rabdosia japonica in preparing anti-acute lung injury drugs. A rabdosia japonica ethanol extract and a macroporous resin part of the rabdosia japonica ethanol extract are respectively made into animal drugs, a mouse is subjected to in vivo drug delivery, lipopolysaccharide LPS is utilized to induce mouse acute lung injury, and then a wet / dry lung weight ratio and the contents of nitric monoxide (NO) and proteins in a bronchoalveolar lavage fluid (BALF) are measured; myeloperoxidase (MPO) and superoxide dismutase (SOD) activities in a lung tissue homogenate are detected; the contents of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in the BALF are detected; and a pathological change of mouse lung tissues after H&E staining is observed. Rabdosia japonica is indicated to have the anti-acute lung injury activity.

Description

technical field [0001] The invention relates to the application of a kind of blue calyx fragrant tea in the preparation of anti-acute lung injury medicine. Background technique [0002] Acute lung injury (ALI) is based on diffuse lung cell injury, pulmonary edema and pulmonary inflammatory cell infiltration caused by pulmonary vascular injury are its pathological features, and the main clinical manifestation is severe hypoxemia , diffuse pulmonary infiltration and pulmonary edema; some patients will eventually develop acute respiratory distress syndrome (ARDS), resulting in irreversible acute respiratory failure and multiple organ dysfunction, with a mortality rate as high as 30-40% The pathogenesis of ALI is complex, and the risk factors for ALI can be direct damage from the lung, or indirect damage to the lung caused by extrapulmonary factors through systemic inflammatory response. (See: Baffert F, Le T, Thurston G, et al. Angiopoietin-1 decreases plasma leakage by reduci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P11/00
Inventor 张健褚纯隽李显伦任慧玲徐乃玉李贺然吴天威陈喜华
Owner SUZHOU UNIV
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