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Composition for treating hyperuricemia and application thereof

A technology of hyperuricemia and composition, which is applied in the field of composition for the treatment of hyperuricemia, can solve the problems of many side effects and few side effects, and achieve the effect of lowering uric acid, no toxic side effects, and good effect

Inactive Publication Date: 2014-08-27
金鑫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, benzbromarone has the best inhibitory effect on URAT1 among commonly used gout drugs in clinical practice. Discover new drug for treating hyperuricemia with better effect and fewer side effects

Method used

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  • Composition for treating hyperuricemia and application thereof
  • Composition for treating hyperuricemia and application thereof
  • Composition for treating hyperuricemia and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] In this example, experiments have proved that the extract of Tianguo has a good effect in treating hyperuricemia.

[0026] Materials and Methods

[0027] 1.1 Test compounds

[0028] Name: Sky Fruit Extract

[0029] 1.2 Preparation of Tianguo extract solution

[0030] Preparation method of Xiangtianguo extract: crush 500g of Xiangtianguo fruit, pass through a 20-mesh sieve, add 10 times the mass of water, extract at a temperature of 65°C for 4 hours, and centrifuge the obtained extract. Concentrate below 70°C to the same quality as the raw material to obtain the Tianguo extract.

[0031] First, dissolve 81.1 mg of Tianguo extract in 4055 μL DPBS, vortex for 1 min, sonicate for 10 min, and centrifuge at 10,000 rpm for 5 min to obtain a mother solution with a concentration of 20 mg / mL. Then dilute the mother liquor with DPBS, respectively to the final concentration containing 0.06, 0.2, 0.6, 2, 6, 20 mg / mL of the fruit extract solution.

[0032] Detection Syst...

Embodiment 2

[0067] In this example, experiments have proved that the composition has a good effect in treating hyperuricemia.

[0068] The preparation method of the composition: the raw materials are mixed according to the following weight ratio, 15 grams of ebony plum, 68 grams of knotweed, 32 grams of herb, 118 grams of Xiangtian fruit, 30 grams of purple grape, 65 grams of winter melon seeds, kelp The buds are 18 grams.

[0069] First wash with clean water to remove impurities, then soak it in warm water of equal quality at 40°C for 2 hours, then add water 4 times the weight of the raw material, extract 4 times at 82°C, cool and filter, then concentrate below 65°C to become the same as the raw material Liquid extracts of equal quality, shake well and seal, obtain the composition for treating hyperuricemia and store in a cool and ventilated place.

[0070] Materials and Methods

[0071] 1.1 Test compounds

[0072] Name: Composition for treating hyperuricemia

[0073] 1.2 Prepa...

Embodiment 3

[0098] In this example, experiments have proved that the urea-lowering composition has a good effect in treating hyperuricemia.

[0099] The difference with embodiment 2 only lies in:

[0100] The preparation method of the composition: the raw materials are mixed according to the following weight ratio, 10 grams of black plum, 50 grams of knotweed, 35 grams of atractylodes, 100 grams of xiangtianguo, 26 grams of purple grapes, 80 grams of winter melon seeds, kelp The buds are 10 grams.

[0101] First wash with clean water to remove impurities, then soak it in warm water at 50°C for 1 hour, then add water three times the weight of the raw material, extract at 75°C for 5 times, cool and filter, then concentrate below 65°C to become the same as the raw material Liquid extracts of equal quality, shake well and seal, obtain the composition for treating hyperuricemia and store in a cool and ventilated place.

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Abstract

The invention belongs to the technical field of medicine preparation, and particularly relates to a composition for treating hyperuricemia and an application thereof. The composition for treating hyperuricemia is characterized by comprising a sky-fruit extractive. The composition comprises 10-20 parts of dark plum, 50-70 parts of polygonum cuspidatum, 12-35 parts of rhizoma atractylodis, 100-120 parts of sky fruit, 26-40 parts of purple grapes, 55-80 parts of waxgourd seeds and 10-20 parts of kelp sprout. The composition is suitable for treatment of hyperuricemia or gout or uric acid nephropathy, particularly treatment of gout and hyperuricemia. The composition for treating hyperuricemia has the beneficial effects that 1. experiments prove that the composition has a relatively good uric acid reduction effect; and 2. by adopting compatibility of traditional Chinese medicines, the composition is capable of improving immunity of organisms while treating the hyperuricemia and has no toxic or side effects.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a composition for treating hyperuricemia and an application thereof. Background technique [0002] Fructus Swietenia Macrophylla (scientific name: Fructus Swietenia Macrophylla), also known as Fructus Swietenia Macrophylla, is a plant belonging to Meliaceae. It originates in the Solomon Islands in the South Pacific. The height of the Fructus Swietenia Macrophylla tree is about 30 meters to 40 meters. It is named for its fruit growing upward , It takes 15 years of growth to bear fruit; Xiangtian fruit is known as "the queen of plants". Unfortunately, due to the lack of modern scientific research and refinement, the value contained in Xiangtian fruit has not been fully developed and widely used for many years. [0003] Xiangtian fruit helps to regulate the internal environment balance between various organs of the human body, guarantee the normal activity of each cell,...

Claims

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Application Information

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IPC IPC(8): A61K36/58A61K36/87A61P19/06A61P13/12
Inventor 金鑫
Owner 金鑫
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