Polymethylmethacrylate bone cement

A bone cement and polymer technology, applied in surgical adhesives, medical science, tissue regeneration, etc., can solve problems such as increased flow resistance of guiding cement

Inactive Publication Date: 2014-09-10
HERAEUS MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, an increase in the viscosity of the cement dough is accompanied by an

Method used

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  • Polymethylmethacrylate bone cement

Examples

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Embodiment Construction

[0106] The invention is explained in more detail in the examples set forth below, which do not, however, limit the scope of the invention.

[0107] In Examples 1 to 3 and Comparative Examples, polymethyl methacrylate-co-methyl acrylate (molar mass> 500,000 g / mol) was used; commercially available dibenzoyl peroxide (BPO, with 25 wt% water desensitization), Aerosil® 380 (Evonik) and glyceryl-1,2,3-tri-caprylate (Sigma-Aldrich).

[0108]

[0109] The composition of the monomer liquid was 99.3 wt% methyl methacrylate and 0.7 wt% N,N-dimethyl-p-toluidine. Methyl methacrylate contained 10 ppm hydroquinone as a stabilizer.

[0110] The powdered cement compositions of Examples 1 to 3 and Comparative Example were each mixed with 10 ml of monomer liquid over a period of 30 seconds. In Examples 1-3, this produced a non-dripping cement dough after about 40 seconds with a processing time of about 8-9 minutes. During the processing phase, the sample could be pressed through an 18 G ca...

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Abstract

The subject matter of the invention is a curable composition for use as bone cement, in particular for augmentation of osteoporotic bone tissue, comprising at least one organic polymer and at least one monomer for radical polymerisation, at least one particulate inorganic additive having a BET surface of at least 40 m2/g, whereby the additive comprises covalently bound hydroxyl groups, whereby the composition further comprises at least one fatty acid ester or a mixture of fatty acid esters. Another subject matter of the invention is the use of said composition for augmentation of osteoporotic bone tissue and particularly preferably for vertebroplasty, kyphoplasty, and augmentation of drill holes in osteoporotic bone tissue, as well as a kit for producing said composition.

Description

technical field [0001] The subject of the present invention is a curable composition for use as bone cement, in particular for the filling of osteoporotic bone tissue, comprising at least one organic polymer and at least one Monomer, at least one BET surface area of ​​at least 40 m 2 / g of particulate inorganic additive, wherein the additive comprises covalently bonded hydroxyl groups, wherein the composition further comprises at least one fatty acid ester or mixture of fatty acid esters. Another subject of the present invention is the use of said composition for filling osteoporotic bone tissue, and particularly preferably for vertebroplasty, kyphoplasty and osteoporotic bone Filling of boreholes in tissue, and kits for preparing said compositions. The composition according to the invention is preferably a polymethylmethacrylate cement. Background technique [0002] Polymethylmethacrylate bone cement (PMMA bone cement) has been known for decades and is based on the pione...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/02A61L27/00A61L31/04A61L31/02A61L31/00
CPCA61L24/06A61L2430/02A61L27/16
Inventor S.福格特
Owner HERAEUS MEDICAL
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