Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of amlodipine besylate oral preparation and preparation method thereof

The technology of amlodipine besylate and amlodipine besylate tablets, which are applied in the field of medicine, can solve the problems of complicated preparation by liposome technology, and achieve the effects of rapid drug dissolution, simple preparation process and improved drug stability

Inactive Publication Date: 2016-08-24
QINGDAO UNIV
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite improved dissolution and increased stability, liposome technology is complex to prepare

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of amlodipine besylate oral preparation and preparation method thereof
  • A kind of amlodipine besylate oral preparation and preparation method thereof
  • A kind of amlodipine besylate oral preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034]

[0035] Preparation Process:

[0036] (1) Dissolve acrylic resin E in absolute ethanol, adjust the pH to 3.0 with citric acid, add amlodipine besylate, and stir to dissolve;

[0037] (2) adding the liquid paraffin solution containing Span;

[0038] (3) Gradually heat up to 35°C, stir, and filter under reduced pressure to obtain microspheres;

[0039] (4) the microspheres are washed with n-hexane to remove free amlodipine besylate on the surface;

[0040] (5) Mix the microspheres with lactose, crospovidone and magnesium stearate evenly, and press into tablets to obtain.

Embodiment 2

[0042]

[0043] Preparation Process:

[0044] (1) Dissolve acrylic resin E in absolute ethanol, adjust the pH to 7.0 with citric acid, add amlodipine besylate, and stir to dissolve;

[0045] (2) adding the liquid paraffin solution containing Span;

[0046] (3) Gradually heat up to 35°C, stir, and filter under reduced pressure to obtain microspheres;

[0047] (4) the microspheres are washed with n-hexane to remove free amlodipine besylate on the surface;

[0048] (5) Mix the microspheres with lactose, crospovidone and talcum powder evenly, and press into tablets to obtain the product.

Embodiment 3

[0050]

[0051]

[0052] Preparation Process:

[0053] (1) Dissolve acrylic resin E in absolute ethanol, adjust the pH to 5.5 with citric acid, add amlodipine besylate, and stir to dissolve;

[0054] (2) adding the liquid paraffin solution containing Span;

[0055] (3) Gradually heat up to 35°C, stir, and filter under reduced pressure to obtain microspheres;

[0056] (4) the microspheres are washed with n-hexane to remove free amlodipine besylate on the surface;

[0057] (5) Mix the microspheres with microcrystalline cellulose, crospovidone and talcum powder evenly, and press into tablets to obtain the product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

An oral preparation of amlodipine besylate and a preparation method thereof. Amlodipine besylate and acrylic resin E are prepared into microspheres, and then directly compressed into tablets with pharmaceutically acceptable auxiliary materials.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oral preparation containing amlodipine besylate and a preparation method thereof. Background technique [0002] Amlodipine besylate is the third-generation long-acting dihydropyridine calcium channel antagonist, which mainly inhibits the calcium storage capacity of myocardial and vascular smooth muscle cell membranes and the ability to combine with calcium ions, allowing extracellular calcium ions to enter through slow channels. The reduction of flow muscle cells directly relaxes vascular smooth muscle, expands vascular arterioles, reduces peripheral resistance, and achieves the effect of lowering blood pressure. It has long half-life, high bioavailability, mild, slow and long-lasting action, few side effects, remarkable curative effect, easy to use, does not affect blood lipid and blood sugar metabolism, and has no damage to liver and kidney functions. The struc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/4422A61K47/32A61P9/12A61P9/08
Inventor 徐丽洒孙勇袁海成徐平沈若武
Owner QINGDAO UNIV