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A kind of preparation method of glabridin

A technology of glabridin and licorice glabra is applied in the field of preparation of glabridin, can solve the problems of complicated purification process, complicated operation process and high cost, and achieves the effects of simple preparation method, good color and low cost

Active Publication Date: 2016-08-24
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that there are many impurities in the extraction and the yield is low; the organic solvent extraction method is also the most reported, but it has the disadvantages of complicated operation process, long time and high solvent cost. For example, in the patent application 201110151677.1, 80% ethanol microwave extract
The two extraction methods also have the disadvantages of complicated subsequent purification process, long purification cycle and high cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Prepare liquid resin extract: dissolve polyvinylpyrrolidone in water to obtain liquid resin extract PVP-K17 aqueous solution, and the content of polyvinylpyrrolidone in the liquid resin extract is 200mg / L;

[0024] (2) Extraction: Grind 100kg of raw licorice glabra and add it to 800kg of the liquid resin extract described in step (1), filter after leaching for 24 hours, add the filter residue to 500kg of liquid resin extract for extraction once, centrifuge Combine the extract after filtering;

[0025] (3) Precipitation: In the state of stirring, add calcium chloride solution with a concentration of 10% to the extract prepared in step (2) until the calcium concentration is 0.02 mol / L, and then let it stand for 12 hours until the precipitation is complete. filter;

[0026] (4) Extraction, concentration, and drying: Add 30kg of ethyl acetate aqueous solution to the precipitate prepared in step (3), the mass of ethyl acetate and water is 1:1, and then add 0.2mol / L phos...

Embodiment 2

[0028] (1) Prepare liquid resin extract: dissolve polyvinylpyrrolidone in water to obtain liquid resin extract PVP-K18 aqueous solution, and the content of polyvinylpyrrolidone in the liquid resin extract is 240mg / L;

[0029] (2) Extraction: crush 100kg of licorice glabra as the raw material and add it to 1000kg of the liquid resin extract described in step (1), filter after leaching for 24 hours, add the filter residue to 600kg of liquid resin extract for extraction once, centrifuge Combine the extract after filtering;

[0030] (3) Precipitation: In the state of stirring, add calcium chloride solution with a concentration of 10% to the extract prepared in step (2) until the calcium concentration is 0.04 mol / L, and then let it stand for 12 hours until the precipitation is complete. filter;

[0031] (4) Extraction, concentration, and drying: add 40kg of ethyl acetate aqueous solution to the precipitate prepared in step (3), the mass ratio of ethyl acetate to water is 1:1, and ...

Embodiment 3

[0033] (1) Prepare liquid resin extract: dissolve polyvinylpyrrolidone in water to obtain liquid resin extract PVP-K18 aqueous solution, and the content of polyvinylpyrrolidone in the liquid resin extract is 500mg / L;

[0034] (2) Extraction: crush 100kg of raw material Glycyrrhizae glabra and add it to 800kg of the liquid resin extract described in step (1), filter after leaching for 24 hours, add the filter residue to 600kg of liquid resin extract for extraction once, centrifuge Combine the extract after filtering;

[0035] (3) Precipitation: In the state of stirring, add calcium chloride solution with a concentration of 10% to the extract prepared in step (2) until the calcium concentration is 0.06 mol / L, and then let it stand for 12 hours until the precipitation is complete. filter;

[0036] (4) Extraction, concentration, and drying: Add 30kg of ethyl acetate aqueous solution to the precipitate prepared in step (3), the mass ratio of ethyl acetate to water is 1:1, and then...

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PUM

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Abstract

The invention discloses a preparation method of glabridin, which comprises the following steps: (1) dissolving polyvinylpyrrolidone in water to obtain a liquid resin extract; (2) crushing the raw material licorice glabra and adding it to the liquid resin extract , leached for 24 hours, filtered, then leached again, and combined the extracts; (3) Added calcium chloride solution to the extract until the calcium concentration was 0.02-0.06 mol / L, then stood still until precipitation precipitated, and filtered; (4 ) Add ethyl acetate aqueous solution to the precipitate prepared in step (3), then add acid to adjust the pH value of the solution to 2.0, extract and turn to dissolve and stand to separate layers to take the ethyl acetate layer, and carry out the ethyl acetate layer solution Concentrate under reduced pressure, then vacuum dry to obtain glabridin with a content ≥ 40%. The preparation method of the glabridin in the present invention is simple, direct and low in cost, and the finally prepared glabridin has a high yield and good color.

Description

Technical field [0001] The present invention involves a method of preparation of luster gifted, which is a chemical extraction technology field. Background technique [0002] Light licorice is derived from the perennial herbaceous plant licorice. It is a flavonoid ingredients unique to light fruit licorice. The content in light fruit licorice is about 0.2%, accounting for about 11%of the ingredients of licorice flavonoids.Chemical structures shown: [0003] (Ι). [0004] Optical licorice is the best active ingredient for the whitening effect of licorice; it has excellent whitening, anti -inflammatory, antibacterial, antioxidant and other effects; in the global makeup industry, light licorice is known as "whitening gold"; in additionThe research of the world is relatively hot. Basic pharmacological tests show that it has a good antioxidant effect and a certain effect of lowering blood lipids and blood pressure. It shows good research value in the prevention and control of cardio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/04
CPCC07D493/04
Inventor 魏元刚杨永安钟慧汤文建
Owner JIANGSU TIANSHENG PHARMA