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Application of calycosin in preparation of immunity inhibitors

A technology of calycosin and immunosuppressant, which is applied in the field of medicine and can solve the problems of unreported uses

Inactive Publication Date: 2014-10-22
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Calycosin is one of the important compounds in astragalus isoflavones, and its use in immunosuppression has not been reported yet

Method used

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  • Application of calycosin in preparation of immunity inhibitors
  • Application of calycosin in preparation of immunity inhibitors
  • Application of calycosin in preparation of immunity inhibitors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0011] Example: Effect of Calycosin A (ConA)-Induced Mouse T Cell Proliferation

[0012] 1 material

[0013] 1.1 Animals

[0014] BALB / c mice, male, weighing 18-20 g, were provided by the Experimental Animal Department of Peking University (permit number: SCXK11-00-0008). The animals were kept in a standard environment: temperature (23±1)°C, relative humidity (55±5)%, light and dark cycle 12h / 12h, and standard pellet feed.

[0015] 1.2 Reagents

[0016] ConA and thiazolyl blue (MTT) were purchased from Sigma, USA; fetal bovine serum (FBS) was purchased from GIBCO, USA; red blood cell lysate, 1640 culture medium, and phosphate (PBS) buffer were purchased from Beijing Maichen Biotechnology Company; DMSO (dimethyl sulfoxide, batch number 20101008) was purchased from Beijing Chemical Plant. Calycosin samples were prepared in DMSO.

[0017] 1.3 Instruments

[0018] Bro-Rad iMark microplate reader (Bio-Rad, USA), Sigma3K-15 centrifuge (Sigma, Germany), CO 2 Incubator (Thermal...

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Abstract

Through the experiments and researches on calycosin, it has been found for the first time that calycosin can prominently inhibit the T lymphocyte proliferation induced by concanavalin A (Con A), has an immunity inhibiting effect, and is advantageously used to prepare immunity inhibitors.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the use of calycosin in preparing immunosuppressants. Background technique [0002] Astragalus membranaceus is a traditional Chinese medicine that strengthens the spleen and replenishes qi. It has the functions of invigorating qi and solidifying the surface, diuretic and detoxification, draining pus, astringing sores and promoting granulation. Hematochezia and metrorrhagia, surface deficiency and spontaneous sweating, Qi deficiency and edema, carbuncle and gangrene, persistent ulceration, blood deficiency and yellowish yellow, internal heat and thirst, chronic nephritis, proteinuria and diabetes (see: National Pharmacopoeia Committee. Pharmacopoeia of the People's Republic of China ( Part One) [z]. Beijing: Chemical Industry Press, 2005: 212-213.). Modern pharmacological studies believe that Astragalus can regulate the immune function of the body and has antiviral effects (see: Yan Hongb...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P37/06
Inventor 徐风叶加张微微蔡少青
Owner PEKING UNIV
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