Small molecular donkey-hide gelatin pure powder tablet and preparation method thereof

A technology of small-molecule donkey-hide gelatin and pure powder tablets, which is applied in the field of medicine, can solve the problems of adding large excipients, etc., and achieve the effects of easy absorption, low fragmentation rate, and convenient taking and carrying

Active Publication Date: 2014-10-22
SHAN DONG DONG E E JIAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem that a large amount of auxiliary materials must be added when small-molecular donkey-hide gelatin is made into tablets in the current technology, the present invention provides a pure powder tablet using small-molecular donkey-hide gelatin as a raw material without adding any auxiliary materials

Method used

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  • Small molecular donkey-hide gelatin pure powder tablet and preparation method thereof
  • Small molecular donkey-hide gelatin pure powder tablet and preparation method thereof
  • Small molecular donkey-hide gelatin pure powder tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] 1. Take 1 kg of oil-free and sugar-free donkey-hide gelatin block and add 3 kg of water, heat the glue until it melts into a uniform glue, and pass through a 120-mesh sieve to remove impurities. After the glue is removed from impurities, cool down to 30°C, add collagen to hydrolyze Enzyme 15g, enzymatically hydrolyzed for 2 hours to obtain donkey-hide gelatin hydrolyzate; then heat and boil the obtained donkey-hide gelatin hydrolyzate, maintain the boiling state for 20 minutes, inactivate the enzyme activity, and carry out fine filtration through a plate and frame filter to obtain a small molecule donkey-hide gelatin liquid and then spray dry The small molecule donkey-hide gelatin fine powder with a water content of 5.3wt% and a total sugar content of 2wt% was obtained.

[0065] 2. Compress the above-mentioned small molecule donkey-hide gelatin fine powder into large pieces and then pulverize it into 20-mesh granules.

[0066] 3. The small-molecule donkey-hide gelatin p...

Embodiment 2

[0069] 1. Take 1 kg of oil-free and sugar-free donkey-hide gelatin block and add 3 kg of water, heat the glue until it melts into a uniform glue, and pass through a 120-mesh sieve to remove impurities. After the glue is removed from impurities, cool down to 32°C and add alkaline protease 5g, collagen hydrolytic enzyme 7g, enzymatically hydrolyzed for 2 hours to obtain donkey-hide gelatin hydrolyzate; then heated and boiled the obtained donkey-hide gelatin hydrolyzate, kept boiling for 20 minutes, inactivated the enzyme, and filtered through a plate and frame filter to obtain small molecule The donkey-hide gelatin liquid was spray-dried to obtain small molecular donkey-hide gelatin fine powder with a water content of 5.3wt% and a total sugar content of 3wt%.

[0070] 2. Compress the above-mentioned small molecule donkey-hide gelatin fine powder into large pieces and then pulverize it into 20-mesh granules.

[0071] 3. The small-molecule donkey-hide gelatin particles prepared in...

Embodiment 3

[0074] 1. Take 1 kg of oil-free and sugar-free donkey-hide gelatin block and add 3 kg of water, heat the glue until it melts into a uniform glue, and pass through a 120-mesh sieve to remove impurities. After the glue is removed from impurities, the glue is cooled to 30°C, and then add papaya Protease 3g, alkaline protease 5g, collagen proteolytic enzyme 5g, enzymatically hydrolyze for 2 hours to obtain donkey-hide gelatin hydrolyzate; then heat and boil the obtained donkey-hide gelatin hydrolyzate, maintain the boiling state for 25 minutes, inactivate the enzyme activity, and pass through a plate and frame filter After fine filtration, the small molecule donkey-hide gelatin liquid was obtained and then spray-dried to obtain a small-molecule donkey-hide gelatin fine powder with a water content of 5.3wt% and a total sugar content of 5.8wt%.

[0075] 2. Compress the above-mentioned small molecule donkey-hide gelatin fine powder into large pieces and then pulverize it into 20-mesh ...

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Abstract

The invention relates to small molecular donkey-hide gelatin pure powder tablets and a preparation method thereof. The small molecular donkey-hide gelatin pure powder tablets take small molecular donkey-hide gelatin as a raw material for the first time, and are processed into tablets without any auxiliary material (the tablets being lozenge tablets or swallowing tablets except for specific explanation). The appearance and hardness of the tablets meet quality standards of tablets. The small molecular donkey-hide gelatin pure powder tablets take 10-30 meshes of small molecular donkey-hide gelatin that contains 2-15 wt% of water and 2-9 wt% of total sugar as a sole raw material and obtained by directly tabletting. The tablets prepared by the preparation process have low granulating rate and lobes rate and good appearance, with hardness, disintegration and friability of the tablets meeting the quality requirements of tablets. The small molecular donkey-hide gelatin pure powder tablets are easy to carry, convenient for taking and accurate in dosage, thereby enlarging suitable population of the donkey-hide gelatin.

Description

technical field [0001] The invention relates to a small molecular donkey-hide gelatin pure powder tablet and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Donkey-hide gelatin is sweet and flat, and its main function is to nourish blood, nourish yin, moisten dryness, and stop bleeding. Therefore, it is often used for blood deficiency and chlorosis, dizziness and palpitations, muscle flaccidity and weakness, restlessness and insomnia, internal movement of deficiency wind, dryness of the lungs, cough, cough and bloody cough, Hematemesis and hematuria, hematochezia and metrorrhagia, fetal leakage during pregnancy, etc. As early as the Eastern Han Dynasty, in the famous medical book "Shen Nong's Materia Medica", donkey-hide gelatin was listed as "top grade", and it was recorded that "long-term use can benefit qi and lighten the body". Modern pharmacological research also shows that donkey-hide gelatin has the functions of nourish...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/36A61K9/20A61P7/04A61P7/06A61P37/04A61P39/06A61P1/08A61P9/06A61P11/14A61P15/00
Inventor 秦玉峰周祥山刘海峰聂洪霞方喆
Owner SHAN DONG DONG E E JIAO
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