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Application of ghrelin in prevention or/and treatment of radiation-induced lung injury

A radiation-induced lung injury and ghrelin technology, applied to medical preparations containing active ingredients, peptide/protein components, respiratory diseases, etc., can solve problems such as unreported ghrelin

Inactive Publication Date: 2014-10-22
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, ghrelin has anti-inflammatory and anti-fibrosis effects. Studies have reported that exogenous administration of ghrelin can alleviate acute lung injury caused by bleomycin or sepsis ( Nakazato M .etal. Eur J Pharmacol. 2011,672(1-3):153-8; Wang P.et al.Am J Respir Crit Care Med2007,176:805-13), but there is no report on the use of ghrelin for the prevention or / and treatment of radioactive lung injury

Method used

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  • Application of ghrelin in prevention or/and treatment of radiation-induced lung injury
  • Application of ghrelin in prevention or/and treatment of radiation-induced lung injury
  • Application of ghrelin in prevention or/and treatment of radiation-induced lung injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The ghrelin was dissolved in PBS and prepared as an injection.

[0025] Take this injection as an example to study the effect of ghrelin on the prevention and treatment of radiation-induced lung injury.

experiment example 1

[0026] Experimental Example 1 Animal experiment of medicine of the present invention

[0027] 1. Experimental method

[0028] 1. Male mice were irradiated with 16Gy of whole lung after adapting to the environment;

[0029] 2. The male mice were randomly divided into 4 groups, n in each group;

[0030] Normal control group (PBS): 0.65mg / kg PBS, i.p., every other day;

[0031] Simple ghrelin group (G): 0.65mg / kg ghrelin, i.p., every other day;

[0032] Irradiation + buffer solution group (RT+PBS): 0.65mg / kg PBS, i.p., every other day; chest irradiation 16Gy once 24 hours before the first injection;

[0033] Radiation + ghrelin treatment group (RT+G): 0.65 mg / kg ghrelin, i.p., every other day; chest irradiation 16Gy once 24 hours before the first injection;

[0034] Each group of mice n≥5.

[0035] 2. In vivo experiment (mouse model of radiation-induced lung injury)

[0036] 1. Establishment of radiation-induced lung injury model mice

[0037] After 1 month of treatment of...

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Abstract

The invention provides a novel medicinal application of ghrelin, namely application of ghrelin in prevention or / and treatment of radiation-induced lung injury, radiation-induced pneumonia and late pulmonary fibrosis. In-vivo experiments verify that the ghrelin is effective in the fields of prevention or / and treatment of radiation-induced lung injury, radiation-induced pneumonia and late pulmonary fibrosis. According to the novel medicinal application of the ghrelin, the ghrelin is creatively applied to prevention or / and treatment of radiation-induced lung injury, radiation-induced pneumonia and late pulmonary fibrosis, and a novel choice is provided to clinical treatment.

Description

technical field [0001] The present invention relates to a new use of ghrelin, in particular to the use of ghrelin in preventing or / and treating radiation-induced lung injury. Background technique [0002] Lung cancer is one of the malignant tumors with high morbidity, poor treatment effect and highest cancer-related mortality. Radiation therapy is an important means of lung cancer treatment, about 50% of lung cancer patients need to receive radiation therapy. Radiation-induced lung injury (RILI) is the most common complication of radiotherapy for lung cancer, with an incidence of 10% to 20%. Radiation-induced lung injury manifests as radiation pneumonitis in the early stage, and progresses to radiation-induced pulmonary fibrosis in the later stage, leading to death in severe cases. At present, RILI still lacks effective prevention and treatment methods. Adrenocorticosteroids, broad-spectrum antibiotics, bronchodilators, and immunosuppressants are still the main means of tr...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P11/00
Inventor 卢铀薛建新周麟
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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