Method for measuring content of 2-pyrazinecarboxylic acid

A pyrazinecarboxylic acid and determination method technology, applied in the field of medicine and chemical industry, can solve the problems of long time, high cost, complicated operation, etc., and achieve the effects of good precision, low precision and overcoming the lack of accuracy

Inactive Publication Date: 2014-10-22
SUNSHINE LAKE PHARM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method is complicated to

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  • Method for measuring content of 2-pyrazinecarboxylic acid
  • Method for measuring content of 2-pyrazinecarboxylic acid
  • Method for measuring content of 2-pyrazinecarboxylic acid

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Embodiment Construction

[0015] A kind of content assay method of 2-pyrazinecarboxylic acid provided by the invention, it comprises the following steps:

[0016] a) Weigh a certain amount of sample, dissolve it in the solution to prepare the test solution, and record the sample weighing;

[0017] b) Perform acid-base neutralization titration on the test solution with a standard solution prepared with an alkaline reference substance, and record the volume of the standard solution consumed at the titration end point, where the concentration of the standard solution is known;

[0018] c) then adopt the following formula to calculate the content of 2-pyrazinecarboxylic acid in the sample:

[0019]

[0020] Wherein, 124.1 is the molecular weight of 2-pyrazinecarboxylic acid, the unit of volume is milliliter, the unit of concentration is mole per liter, and the unit of mass is gram. In said method, the basic reference substance therein can be a hydroxide compound, preferably a metal salt of hydroxide, m...

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Abstract

The invention provides a method for measuring the content of 2-pyrazinecarboxylic acid, and relates to the field of medicine chemical engineering. The method comprises the steps of performing acid-base neutralization titration on the 2-pyrazinecarboxylic acid in a sample through a standard solution prepared by an alkaline reference substance, and calculating the content of the 2-pyrazinecarboxylic acid in the sample according to the amount of the consumed standard solution. The method disclosed by the invention is simple and quick, high in accuracy, low in cost and practicable.

Description

technical field [0001] The invention relates to the field of medicine and chemical industry, in particular to a method for determining the content of 2-pyrazinecarboxylic acid. Background technique [0002] 2-Pyrazinecarboxylic acid, also known as pyrazine-2-carboxylic acid, is a nitrogen heterocyclic compound with a molecular weight of 124.1. Its structural formula is as follows: [0003] [0004] It is often used as an intermediate in spices or pharmaceutical chemicals. In the field of pharmaceutical chemicals, it is mainly used to synthesize the anticancer drug oltipraz and the first-line anti-tuberculosis drug pyrazinamide. At the same time, it is also a widely used bridging ligand, which can coordinate with various metals (such as transition metals and rare earth elements) and is a commonly used coordination reagent. 2-pyrazinecarboxylic acid is a kind of white needle-like crystal, which can be slightly soluble in cold water, soluble in hot water, and insoluble in ...

Claims

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Application Information

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IPC IPC(8): G01N27/42
Inventor 宋学志
Owner SUNSHINE LAKE PHARM CO LTD
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