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A kind of anti-cancer synergistic composition

A composition and drug technology, applied in the field of medicine, can solve the problems of not using carotin combined with cyclophosphamide for anti-cancer literature, and not using carotin for anti-cancer, so as to achieve low side effects and adverse reaction rates, low toxicity, and reduced Toxic effects

Inactive Publication Date: 2016-02-24
甘肃皓骏药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] By searching the existing technologies at home and abroad, it is found that there is no literature report on the use of carotin to fight cancer, and there is no literature report on the use of carotin combined with cyclophosphamide to fight cancer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 injection

[0016] Carotene 1.6g

[0017] Cyclophosphamide 0.1g

[0018] Soybean oil for injection 18g

[0019] Glycerin 2.6g

[0020] Soy Lecithin 1.5g

[0021] Add water for injection to 100ml

[0022] Preparation process: Disperse soybean lecithin and glycerin in 60ml of water for injection, then mix carrotin, cyclophosphamide and soybean oil for injection evenly to prepare an oil phase, then add the oil phase to the water phase, and add Stir while stirring, after homogenization, ultrasonication for 1 hour, then dilute to 100ml with water for injection, then transfer to a high-pressure homogenizer, emulsify for 30 minutes, fill, sterilize, and obtain.

Embodiment 2

[0023] The preparation of embodiment 2 injection

[0024] Carotene 3.2g

[0025] Cyclophosphamide 0.1g

[0026] Soybean oil for injection 18g

[0027] Glycerin 2.0g

[0028] Propylene glycol 5.0g

[0029] Soy Lecithin 1.5g

[0030] Add water for injection to 100ml

[0031] Preparation process: first disperse soybean lecithin, glycerin, and propylene glycol in 60ml of water for injection, then mix carrotin, cyclophosphamide, and soybean oil for injection evenly to prepare an oil phase, and then add the oil phase to the water phase, Stir while adding, after homogenization, sonicate for 1 hour, then dilute to 100ml with water for injection, then transfer to a high-pressure homogenizer, emulsify for 30 minutes, fill, and sterilize to obtain the product.

Embodiment 3

[0032] Embodiment 3 carotin combined with cyclophosphamide on S 180 Influence test of tumor inhibition rate in tumor-bearing mice

[0033] 40 KM mice, 18-22 g, half male and half male. S 180 Ascites of sarcoma was inoculated for 8 days, and 5 mL of ascites was extracted, put into a sterile petri dish, diluted with normal saline to a 1:3 tumor cell suspension, mixed well, and inoculated with S 180 The sarcoma was found in the right forelimb armpit of all KM mice. After 24 hours, they were randomly divided into the following four groups: model control group, carotin group, cyclophosphamide group, and combined drug group. There were 10 mice in each group, half female and half male. From the second day of inoculation, intraperitoneal injection administration, the test substance and dosage of each group are as follows:

[0034] Model control group: equal volume of normal saline;

[0035] Carotin group: 200mg / (kg·d) carotin;

[0036] Cyclophosphamide group: 25mg / (kg·d) cyclopho...

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Abstract

The invention discloses an anticancer synergistic composition. Active components of the anticancer synergistic composition comprise daucosterol and cyclophosphamide, and preferably, a weight ratio of daucosterol to cyclophosphamide is 10-50: 1. The daucosterol and cyclophosphamide can produce synergistic cancer-resistant effects. Daucosterol is natural extract and has very small toxicity, small side effects and a low adverse reaction rate. The use amount of cyclophosphamide in the anticancer synergistic composition is only 1 / 2 of the conventional use amount and thus a cost, side effects and an adverse reaction rate are low.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an anticancer synergistic composition. Background technique [0002] At present, cancer is one of the major diseases that seriously affect human health and threaten human life. Together with cardiovascular and cerebrovascular diseases and accidents, cancer constitutes the top three causes of death in all countries in the world today. Therefore, the World Health Organization and the health departments of governments of various countries have listed conquering cancer as a top priority. There are three main ways to treat cancer in the world. One is surgical resection to remove diseased tissue to prevent the spread of cancer cells; chemotherapy or radiotherapy is used to kill cancer cells; the third is drug treatment. Adopt the method for surgical excision to increase patient's misery, hurt its vitality, and expense is huge. With radiotherapy, while killing cancer cel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P35/00A61K31/675
Inventor 于法周
Owner 甘肃皓骏药业有限公司
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