Agents, methods, and devices for affecting nerve function
A medicament, a functional technology, applied in the field of treating a disease of the autonomic nervous system in a patient
Inactive Publication Date: 2014-12-10
艾米丽 A 斯坦 +3
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- Abstract
- Description
- Claims
- Application Information
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Problems solved by technology
Finally, damage to renal nerves by RF ablation is not a well-controlled (all or nothing) process and does not easily direct itself in terms of specifically targeting nerve cells and limiting induced damage to adjacent cells. damage adjustment
Method used
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Examples
Experimental program
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Effect test
example 1
[0072] The efficacy of different agents in affecting nerve function was evaluated using a rat sciatic nerve block model. Groups of rats were injected with 0.3cc of the drug formulation in the left leg near the sciatic notch. These rat groups, agents, and doses are listed in the table below:
[0073] Group
potion
Dose (mg / kg)
1
100％
2
Guanethidine
5.77
3
1.06
4
1.44
5
3.82
6
0.27、0.36
7
Digoxin + Captopril + Indomethacin
0.27、5.88、0.22
[0074] Figures 12A-12D The results of these different agents on rat left leg muscles are shown. The effects of these agents were measured based on four tests: (1) nerve conduction, (2) sensory ability, (3) motor function, and (4) applied pressure.
[0075] Figure 12A Results of nerve conduction tests are shown. The nerve conduction test evaluates...
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Abstract
Agents, methods, and devices for affecting nerve function are described. One embodiment of an agent includes a cardiac glycoside, an ACE inhibitor, and an NSAID. The agent may be delivered locally in a site-specific manner to a targeted nerve or portion of a nerve. For example, the agent may be delivered locally to the renal nerves to impair their function and treat hypertension. One embodiment of a delivery device includes one or more needle housings supported by a balloon. A delivery needle is slidably disposed within a needle lumen of each needle housing.
Description
[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Patent Application No. 61 / 551,921, filed October 26, 2011, which is incorporated by reference in its entirety. Background technique [0003] Renal denervation involves removing nerves from the kidney to treat high blood pressure. Sympathetic feedback from the kidneys has been found to be at least partly responsible for hypertension, and renal denervation has the effect of lowering blood pressure. [0004] One approach to renal denervation involves ablation of renal nerves using high frequency (RF) energy. An RF catheter is placed within the renal artery and placed in contact with the renal artery wall prior to application of RF energy to the vascular tissue and renal nerves. Disadvantages of this approach include damage to the renal artery wall and other surrounding tissues. In addition, the long-term effects of RF ablation are not well understood. For example, th...
Claims
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IPC IPC(8): A61K31/401A61K31/405A61K31/704A61P9/02
CPCA61K31/4166A61K31/405A61K33/14A61K31/7048A61K31/401A61K31/55A61K31/198A61K31/4164A61K31/4409A61K31/4704A61K31/496A61K31/635A61K39/395A61K45/00A61K2300/00A61P11/00A61P11/06A61P21/00A61P25/00A61P25/06A61P25/24A61P25/28A61P29/00A61P3/04A61P9/00A61P9/02A61P9/06A61P9/12A61K9/0012A61K38/1787A61K45/06A61M25/0084A61M25/10A61M2025/0086A61M2025/1093
Inventor 艾米丽·A·斯坦克里斯蒂娜·D·斯汪森迈克尔·A·埃文斯空达帕瓦勒·T·文卡特斯瓦拉-拉欧
Owner 艾米丽 A 斯坦