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A kind of transdermal absorption preparation

A technology for transdermal absorption preparations and penetration enhancers, which is applied in the field of external TDS preparations and can solve the problems of inconvenient use and poor targeting of tobramycin

Active Publication Date: 2016-08-31
嘉善县魏塘资产管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the disadvantages of inconvenient use and poor targeting of existing tobramycin, the present invention invented a tobramycin skeleton transdermal absorption preparation

Method used

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  • A kind of transdermal absorption preparation

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Embodiment 1

[0018] Including four parts: storage layer, adhesive layer, backing layer and protective layer. The medicine storage layer of the storage layer includes two layers: medicine storage layer 1 and medicine storage layer 2. The composition of medicine storage layer 1 is tobramycin 6g, polyvinyl chloride 52g, serine 0.5g, N-ethylpyrrolidone 2g, sodium lauryl sulfate 4g; the composition of drug storage layer 2 is tobramycin 6g, pressure sensitive adhesive 1g, serine 0.5g, N-ethyl 2 g of pyrrolidone and 2 g of sodium lauryl sulfate; the adhesive layer includes 3 g of pressure-sensitive adhesive. The other component of this example is water. Preferably, the aforementioned 1 "g" represents 1 gram.

[0019] The preparation method is as follows: Dissolve the drug tobramycin in the drug storage layer 1 with water, mix it with polyvinyl chloride, serine, N-ethylpyrrolidone, and sodium lauryl sulfate, and place it on a clean, flat and smooth glass plate , Make it into a thin film, dry at 60-...

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Abstract

The application relates to a TDS preparation for external use, in particular, a skeleton-type transdermal absorption preparation with tobramycin as an active ingredient and a preparation process thereof, wherein a combination of serine, N-ethylpyrrolidone and sodium lauryl sulfate is used As a penetration enhancer, the weight ratio of the three is 1:4:6.

Description

Technical field [0001] This application relates to a TDS preparation for external use, specifically, a skeleton type transdermal absorption preparation with tobramycin as an active ingredient and a preparation process thereof. Background technique [0002] Tobramycin is an aminoglycoside drug that is actively transported through the bacterial cell membrane and binds to the special receptor protein of the 30S subunit of the bacterial ribosome. It interferes with the formation of the initial complex between the message ribonucleic acid and the 30S subunit, and inhibits Protein synthesis; misreading DNA, leading to the synthesis of non-functional proteins; making polyribosomes split and lose the function of protein synthesis. It is clinically used for local infections of external eyes and appendages caused by sensitive bacteria. Compared with other aminoglycoside antibiotics, it has a wider antibacterial spectrum, higher curative effect, and less toxic reaction. Staphylococcus aur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/702A61K47/22A61P31/04
Inventor 李淑兰
Owner 嘉善县魏塘资产管理有限公司