A spectrally encoded confocal and optical coherence tomography collaborative imaging method and system

Abstract

The invention discloses a spectrally encoded confocal and optical coherence tomography collaborative imaging method and system. The system is based on the combination of optical coherence tomography (OCT) imaging technology and spectrally encoded confocal microscopy (SECM) technology. The sample arm of the sample arm and the sample arm of the SECM system share the same optical path, so that the beams emitted from the OCT system and the SECM system in the sample arm scan the same position of the sample synchronously, and the light returned from the single scattering of the sample is transmitted to the detection arm. The proposed detection arm uses two fiber optic collimating mirrors to irradiate the grating at different incident angles, so that the grating diffracts two sets of non-overlapping spectral signals, which are the signals of SECM and OCT. The optical path of the sample arm in the present invention is simpler , is easy to implement, the optical path is more compact and stable, the imaging quality of the system is high, and the imaging of biological tissue structures is more accurate.

Description

technical field [0001] The present invention relates to spectral encoding confocal microscopy technology and optical coherence tomography imaging technology, in particular to a synchronous imaging technology of spectral encoding confocal and optical coherence tomography. Background technique [0002] Optical coherence tomography (OCT) technology is an emerging biomedical optical imaging technology, which can realize non-contact, non-destructive, high-resolution imaging of the structure and physiological functions of biological tissues. Early detection and in vivo biopsy have broad application prospects. [0003] Spectrally Encoded Confocal Microscopy (SECM) technology is a confocal imaging method of micro-invasive single-mode fiber, which uses a broadband light source and a diffraction grating to simultaneously detect the reflectance at multiple lateral positions of the sample. By detecting the spatial information of the sample arm, the light-encoded confocal microscopy sys...

AI Technical Summary

Problems solved by technology

[0005] Most of the currently proposed collaborative imaging methods for the OCT system and the SECM system are based on the swing of the scanning galvanometer to switch between the two systems. The structure of the system using the galvanometer as a mechanical switch is relatively complicated, and there is no To achieve real simultaneous scanning and imaging, if the sample to be measured is a living sample, it is very likely that the imaging positions of the two systems will not be aligned due to the movement of the living body during the switching process

In addition, most of the currently proposed collaborative imaging methods for the OCT system and the SECM system use two light sources for the OCT system and the SECM system respectively, and also use two detection arms to detect the sample signal of the OCT system and the SECM system respectively. sample signal, which makes the integrated system too complicated, not stable enough, and the construction cost is high

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