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Use of patchoulone and its derivatives

A patchoulone ketone and application technology are applied in the application field of patchoulone and its derivatives, achieving good clinical application prospect and remarkable inhibitory effect.

Inactive Publication Date: 2017-11-07
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no related reports about anti-tumor growth at home and abroad.

Method used

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  • Use of patchoulone and its derivatives
  • Use of patchoulone and its derivatives
  • Use of patchoulone and its derivatives

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0027] Experimental Example 1 In vitro anti-tumor experiment of patchouli ketone of the present invention

[0028] 1. Materials and instruments

[0029] 1.1 Cell lines

[0030] PC3 cells (human androgen-independent prostate cancer cells) and DU145 cells (human androgen-independent prostate cancer cells) were purchased from the Cell Bank of Shanghai Chinese Academy of Sciences.

[0031] 1.2 Drugs and control drugs

[0032] Experimental drug: invented drug: patchouli ketone.

[0033] Positive drug: paclitaxel injection: the specification is 6mg / ml, 5ml / bottle. Produced by Taiji Group Sichuan Taiji Pharmaceutical Co., Ltd. Approval number: Guoyao Zhunzi H19994040, production batch number: 12060014.

[0034] 1.3 Media, reagents and consumables

[0035] F-12 medium (Gibco TM company); fetal bovine serum (Lanzhou Minhai Bioengineering Co., Ltd., batch number 20120510); 0.25% EDTA-pancreatin (KGI Biological Company); tetramethylazolazolium blue (MTT) is Amerseo product; penici...

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Abstract

The invention provides the application of patchoulone or its pharmaceutically acceptable salt or hydrate in preparing medicine for treating cancer. The invention also provides an antitumor drug. The patchouli ketone of the present invention has an anti-tumor effect, especially a remarkable inhibitory effect on prostate cancer, can be effectively used for treating prostate cancer and its metastatic lesions, and has good clinical application prospects.

Description

technical field [0001] The invention relates to a new application of patchoulone, in particular to the application of patchoulone in the preparation of anticancer drugs. Background technique [0002] Prostate cancer is one of the most common malignant tumors in elderly men. Worldwide, the incidence of prostate cancer ranks second among all malignant tumors in men. In the United States, the incidence of prostate cancer ranks first among all male malignancies, and the death rate ranks second. In our country, its incidence rate has leapt to the third among malignant tumors of the genitourinary system in recent years. Prostate cancer has few clinical symptoms in the early stage, and most patients have reached the advanced stage when they are diagnosed, losing the opportunity for radical surgery. Among patients undergoing radical prostatectomy, 27% to 53% have local recurrence or distant metastasis within 10 years after operation. Endocrine therapy is currently the main treat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/366A61P35/00A23G3/36A23F3/14
Inventor 彭成蔡剑熊亮万峰
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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