Compound tripterygium wilfordii gel paste with high effect and low toxicity and preparation method thereof

The technology of rattan gel paste and tripterygium wilfordii, which is applied in the field of traditional Chinese medicine production, can solve problems such as unfavorable extraction and poor control of toxicity, and achieve the effects of accurate content, reduced toxicity, and improved safety

Active Publication Date: 2014-12-24
THE THIRD AFFILIATED HOSPITAL OF ZHEJIANG CHIENSE MEDICAL UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is not only unfavorable for the extraction of effective components in the toxic Chi

Method used

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  • Compound tripterygium wilfordii gel paste with high effect and low toxicity and preparation method thereof
  • Compound tripterygium wilfordii gel paste with high effect and low toxicity and preparation method thereof
  • Compound tripterygium wilfordii gel paste with high effect and low toxicity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] prescription composition

[0045] Tripterygium wilfordii extract (calculated as norzera wood aldehyde) 0.175g Nuxychnium extract (calculated as strychnine) 1.75g

[0046] Paeoniae Alba 65g, Smilax 60g, Honeysuckle 70g, Mori 58g, Licorice 20g, Danpi 50g, Myrrh 50g

[0047] Preparation:

[0048] 1) Decoction pieces of the whole root of Tripterygium wilfordii 55g, extracted twice under reflux with ethyl acetate, 1 hour each time, 550mL for the first time, 330mL for the second time. Combine the extracts. The ethyl acetate was recovered, and dried under reduced pressure to obtain 2.75 g of Tripterygium wilfordii extract (containing 6.83% of norzeralin).

[0049] 2) 250 g of Nuxychnium Semen coarse powder was extracted twice under reflux with 50% ethanol at pH 5.0, 3 hours each time, 2500 mL for the first time and 1500 mL for the second time. The extracts were combined and concentrated. Add 40% sodium hydroxide solution to adjust the pH to 12.0, extract with ethyl acetat...

Embodiment 2

[0056] prescription composition

[0057] Tripterygium twig extract (calculated as norzera wood aldehyde) 0.25g Nuxychnium extract (calculated as strychnine) 5.5g

[0058] Paeoniae Alba 67g, Smilax 63g, Lonicerae 65g, Turmeric 50g, Licorice 27g, Herba sativa 50g, Frankincense 50g

[0059] Preparation:

[0060] 1) Decoction pieces of the whole root of Tripterygium wilfordii 80g, heated and extracted twice with ethyl acetate, 1 hour each time, 800mL for the first time, 480mL for the second time. Combine the extracts. The ethyl acetate was recovered and dried under reduced pressure to obtain 4.02 g of Tripterygium wilfordii extract (containing 6.73% of norzeralin).

[0061] 2) 700 g of Nuxychnium Semen coarse powder was extracted twice under reflux with 50% ethanol at pH 5.0, 3 hours each time, 7000 mL for the first time and 4200 mL for the second time. The extracts were combined and concentrated. Add 40% sodium hydroxide solution to adjust the pH to 12.0, extract 3 times wit...

Embodiment 3

[0068] prescription composition

[0069] Tripterygium twig extract (calculated as norzera wood aldehyde) 0.35g Nuxychnium extract (calculated as strychnine) 3.5g

[0070] Paeoniae Alba 70g, Smilax 65g, Honeysuckle 60g, Mori 50g, Licorice 23g, Frankincense 40g, Paeonol 40g

[0071] Preparation:

[0072] 1) 110g decoction pieces of the whole root of Tripterygium wilfordii, extracted twice under reflux with ethyl acetate, 1 hour each time, 1100mL for the first time, 660mL for the second time. Combine the extracts. The ethyl acetate was recovered, and dried under reduced pressure to obtain 5.5 g of Tripterygium wilfordii extract (containing 6.66% of norzeralin).

[0073] 2) Nuxychnium coarse powder 450, 50% ethanol with pH 5.0 was heated and refluxed twice, each time for 3 hours, the first time was 4500 mL, the second time was 2700 mL. The extracts were combined and concentrated. Add 40% sodium hydroxide solution to adjust the pH to 12.0, extract 3 times with ethyl acetate, a...

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Abstract

The invention discloses a compound tripterygium wilfordii gel paste and a preparation method thereof. The compound tripterygium wilfordii gel paste is prepared from the following raw materials accompanied by a matrix in parts by weight: 0.175-0.7 part of tripterygium wilfordii extractives calculated in terms of the content of demethylzeylasteral, 1.75-7 parts of semen strychni extractives calculated in terms of the content of strychnine, 60-70 parts of radix paeoniae alba, 60-70 parts of glabrous greenbrier rhizome, 60-70 parts of caulis lonicerae japonicae, 20-30 parts of liquorice, one of the following two raw materials: less than or equal to 50 parts of myrrh and less than or equal to 50 parts of frankincense, and one or more of the following four raw materials: less than or equal to 60 parts of ramulus mori, less than or equal to 50 parts of cortex moutan, less than or equal to 50 parts of rhizoma curcumae longae and less than or equal to 50 parts of herba siegesbeckiae. The compound tripterygium wilfordii gel paste disclosed by the invention has the advantages of reasonability of formula, high effect and low toxicity, can be used for treating the wind-dampness arthromyodynia and provides a new choice of medicines for general patients suffering from the wind-dampness arthromyodynia.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine production, and specifically relates to a medicine with the functions of expelling wind and dampness, eliminating numbness and relieving pain, and is mainly used for rheumatoid arthritis, joint redness, heat pain or joint swelling pain, stiffness and deformation caused by rheumatic heat and wind-cold dampness. , activity limitation embolism compound tripterygium wilfordii gel ointment. The invention also provides a preparation method of the gel paste. Background technique [0002] Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic progressive joint synovial lesions, which can occur in any age group, and the peak incidence is between 30 and 50 years old. , female patients are about 2.5 times that of males. The course of RA is protracted and persistent and recurrent, which can lead to the destruction of cartilage and bone in the joints, resulti...

Claims

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Application Information

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IPC IPC(8): A61K36/90A61K36/896A61K36/9066A61K9/06A61P29/00A61P19/02
Inventor 方剑乔马凤森陈海波方多凤方芳梁宜刘丹
Owner THE THIRD AFFILIATED HOSPITAL OF ZHEJIANG CHIENSE MEDICAL UNIV
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