A kind of polypeptide and its preparation method and use

A technology of polypeptides and polypeptide fragments, applied in the field of polypeptides and their preparation, can solve the problems of low yield of AstressinB, high production cost of AstressinB, high market price, etc.
CN104231059BInactive Publication Date: 2016-12-28HYBIO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HYBIO PHARMA
Publication Date
2016-12-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of polypeptide synthesis and particularly relates to a polypeptide as well as a preparation method and use thereof. The amino acid sequence of the polypeptide is shown in SEQ ID NO: 1, and the terminal N of the polypeptide is acetylated. From the terminal N, amido bond cyclization is carried out on an X8 main chain at the 22nd site and an X9 side chain at the 25th site in the polypeptide. The polypeptide after amido bond cyclization provided by the invention retains the biological activity of Astressin B, is high in metabolic stability and can be used for effectively preventing and treating alopecia. The preparation method of the polypeptide has the advantages of low production cost and high yield.
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Description

technical field

[0001] The invention relates to the field of polypeptide synthesis, in particular to a polypeptide and its preparation method and application. Background technique

[0002] Alopecia refers to the phenomenon that hair falls out, comprises physiological alopecia and pathological alopecia. Physiological hair loss refers to the phenomenon of hair loss in the catagen and telogen phases. Since the hair entering the catagen and the newly entering the growth phase is constantly in a dynamic balance, it can maintain a normal amount of hair. Pathological alopecia refers to the abnormal or excessive shedding of hair. The main reason is that the heat and toxin in the human blood cannot be discharged, so that certain diseases occur in the human body. The hair follicles shrink, the hair falls off, and the hair is easy to break. Elasticity, the more serious cases are general removal and complete removal. According to different pathogenesis, pathological alopecia is mainly...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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