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Applications of Xinnaoxin capsule in preparation of antidepressant medicines

A technology of antidepressants and capsules, applied in the field of medicine, to achieve the effects of protecting brain tissue, reducing NO level and increasing MDA level

Inactive Publication Date: 2015-01-07
三普药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the effect has not been reported in antidepressants

Method used

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  • Applications of Xinnaoxin capsule in preparation of antidepressant medicines
  • Applications of Xinnaoxin capsule in preparation of antidepressant medicines
  • Applications of Xinnaoxin capsule in preparation of antidepressant medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Antidepressant Animal Experiment of Xinnaoxin Capsule

[0011] 1 Experimental materials

[0012] 1.1 Drugs and reagents

[0013] Xinnaoxin Capsules, the contents are tan powder, 0.5g / capsule, batch number: 120803 Sanpu Pharmaceutical Co., Ltd.; during the experiment, remove the shell of the capsules, grind the contents, and prepare the required concentration with double distilled water. Amitriptyline, specification: 25 mg, batch number: H43020561, Hunan Dongting Pharmaceutical Co., Ltd.; during the experiment, it was ground into powder and prepared to the required concentration with double distilled water. Kits for iNOS, NO, SOD, MDA, and GSH were purchased from Nanjing Jiancheng Institute of Bioengineering. Acetic acid (Nanjing Chemical Reagent Co., Ltd., batch number 13040710461); absolute ethanol (Nanjing Chemical Reagent Co., Ltd., batch number 050410352); chloral hydrate (Sinopharm Chemical Reagent Co., Ltd., batch number 20130314).

[0014] 1.2 Experimental ani...

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Abstract

The invention discloses applications of a Xinnaoxin capsule in preparation of antidepressant medicines, particularly applications in preparation of medicines treating depression caused by bilateral damage to olfactory bulbs, and applications in preparation of medicines treating depression caused by high-concentration NO. The capsule plays an anti-depression role by inhibiting activity of iNOS, reducing the NO level and inhibiting cell apoptosis. In addition, the capsule protects brain tissues by balancing an oxidation and anti-oxidation system, and plays a role of protecting nerves, thus achieving anti-depression effects.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Xinnaoxin capsules in the preparation of antidepressants. Background technique [0002] The mechanism of depression is complex. Studies have shown that the occurrence of depression is related to the excessive generation or reduction of active oxygen and active oxygen free radicals. When the elimination ability of the endogenous antioxidant defense system is exceeded, excessive free radicals directly Indirectly cause biological membrane lipid peroxidation, intracellular protein and enzyme denaturation, DNA damage, which leads to nerve cell apoptosis. As an atypical nerve messenger in cells and between cells, NO plays a dual role in the central nervous system. Physiological concentration of NO acts as a signaling molecule, which can guide axon growth, participate in synaptic remodeling, and play a role in regulating, Transduction; but high concentration of NO...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K9/48A61P25/24
CPCA61K36/41A61K36/185A61K36/815
Inventor 史公权邹存生马俊仓吴留强夏彬牛蓉贺生玲李成秀
Owner 三普药业有限公司
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