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Method for manufacturing flexible-substrate metal microneedle array

A flexible substrate and microneedle array technology, applied in the directions of microneedles, metal material coating process, needle heads, etc., can solve the problems of limiting the development and promotion of metal microneedles, synchronizing the expensive production cycle of X-rays, and the process being complicated and difficult to control. Achieve significant economic and social benefits, easy operation, and easy mass production.

Active Publication Date: 2015-01-28
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high cost of synchronous X-rays and the long production cycle, the cost of producing microneedles with LIGA technology is very high, and the process is complicated and difficult to control. Metal processing technology limits the development and promotion of metal microneedles.

Method used

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  • Method for manufacturing flexible-substrate metal microneedle array
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  • Method for manufacturing flexible-substrate metal microneedle array

Examples

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Embodiment 1

[0032] A method for manufacturing a metal microneedle array on a flexible base, the metal microneedle array on a flexible base comprises a flexible base 1 and a microneedle array 2, wherein the microneedle array 2 is fixed on the flexible base 1;

[0033] The fabrication method of the flexible base metal microneedle array comprises the following steps:

[0034] a. Production of "solidifiable ferromagnetic fluid": the solidifiable ferromagnetic fluid includes magnetic nano or micro particles, polymer materials and curing agents, which are mixed in an appropriate proportion according to performance requirements. The present embodiment selects magnetic nanoparticle, and selects epoxy resin as polymer material, selects epoxy resin curing agent as curing agent, and its ratio is: magnetic nanoparticle: epoxy resin: epoxy resin curing agent=5:3: 2;

[0035] b. According to the predetermined design, the soft solid material is made into a sheet-like flexible substrate 1, which i...

Embodiment 2

[0040]This embodiment is similar to Embodiment 1, except that the method of "arranging the droplets of solidifiable ferromagnetic fluid in an array on the flexible substrate 1" in this embodiment is: The fluid is loaded into the cavity formed by the hole mold 5, the piston and the barrel wall, and the pressure is applied through the piston to make the solidifiable ferromagnetic fluid flow out from the small hole of the hole mold 5 and adhere to the flexible substrate 1 to form a droplet array.

Embodiment 3

[0042] This embodiment is similar to Embodiment 1, except that the method of "arranging the solidifiable ferrofluid droplets on the flexible substrate 1 in an array" in this embodiment is: using a hollow needle mold 6 , to form a droplet array in a manner of pouring into the flexible substrate 1 .

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Abstract

The invention relates to the technical field of biomedical engineering methods, in particular to a method for manufacturing a flexible-substrate metal microneedle array. The method includes a, preparing solidifiable iron magnetic fluid; b, manufacturing a flexible substrate; c, arranging liquid drops of the solidifiable iron magnetic fluid on the flexible substrate in an array manner to form a combination of a solidifiable iron magnetic fluid liquid drop array and the flexible substrate; d, disposing the combination obtained in the step c in a magnetic field to enable each liquid drop to become needle-shaped, and solidifying each liquid drop to form a stable and solidified microneedle array structure; e, forming a layer of metal uniform in texture on the surface of the microneedle array structure obtained in the step d through vacuum sputtering to form a metal microneedle array. The microneedle array structure is formed by through mutual action between the magnetic field and the iron magnetic fluid liquid drops containing magnetic nanoscale iron magnetic particles.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering methods, and more specifically, to a method for manufacturing a flexible base metal microneedle array. Background technique [0002] The improvement of drug delivery is a basic and important topic in the medical field. [0003] Its traditional methods mainly include oral administration and injection. Although the former is convenient and easy to implement, the efficiency of the drug is low due to the interference of the digestive system; while the latter avoids the shortcomings of oral administration, but it often brings more pain to patients. In addition, both of the above-mentioned aspects of drug sustained release still need to be improved. [0004] Currently, emerging drug delivery methods mainly include transdermal drug delivery and injection drug delivery. The former relies on the penetration of drugs into the skin for drug delivery. Due to the obstruction of the skin, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00B81C1/00
CPCA61M37/0015A61M2037/0023A61M2037/0053
Inventor 蒋乐伦陈志鹏任磊唐珮珺陈珂云
Owner SUN YAT SEN UNIV
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