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Preparation method of medicinal carboxymethyl starch

A technology of carboxymethyl starch and a production method, applied in the field of starch production, can solve problems such as difficulty in discharging, gelatinization, reaction failure, etc., and achieve the effects of low degree of substitution and high gelatinization temperature

Active Publication Date: 2015-01-28
DONGGUAN DONGMEI FOOD
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  • Abstract
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AI Technical Summary

Problems solved by technology

Gelatinization and gelation are prone to occur during the production process, resulting in reaction failure, difficulty in discharging, and product scrapping

Method used

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Examples

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Effect test

Embodiment 1

[0021] A kind of production method of medicinal carboxymethyl starch, the preparation of carboxymethyl starch comprises the following steps:

[0022] (1) Use an electronic balance to weigh 100 units of starch at room temperature, put it into a reaction tank, add 25 units of 95% ethanol to stir and disperse it into a uniform starch slurry, and move the reaction tank into a water bath with a stirrer. Start stirring, and heat up the water bath until the slurry temperature reaches 55~60°C;

[0023] (2) Take 25 units of 40% NaOH solution, slowly drop it into the starch slurry, after adding, react for 25~30min;

[0024] (3) Take 10 units of chloroacetic acid, dissolve in 125 units of 95% ethanol, stir well, add all of them into the reaction slurry, and react for 25-30 minutes;

[0025] (4) Take 40% NaOH 35 unit mass, slowly drop into the starch slurry, after adding, react for 20~25min;

[0026] (5) Take 10 units of chloroacetic acid, add it directly into the reaction slurry, and r...

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PUM

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Abstract

The invention provides a preparation method of medicinal carboxymethyl starch. The preparation method of the carboxymethyl starch is characterized by comprising the steps of adding ethanol, mixing and heating, adding alkali liquor, adding chloroacetic acid, adding ethanol for the second time, adding alkali liquor for the second time, adding chloroacetic acid for the second time, neutralizing, dehydrating, washing, drying, discharging powder and the like; the medicinal carboxymethyl starch with the substitution degree of 0.28 can be prepared; the finished product can be swelled in a small amount of cold water; particles are expanded and insoluble after absorbing water, and do not form a colloidal solution, the solubility in water is increased with the increase of the substitution degree, the substitution degree is low, and the gelatinization temperature is high. Conditions that the medicinal carboxymethyl starch is used as an efficient disintegrating agent and excipient of insoluble drugs and soluble drug tablets are satisfied.

Description

technical field [0001] The invention relates to the technical field of starch production, in particular to a production method of medicinal carboxymethyl starch. Background technique [0002] In the current general practice, the solvent method is mainly used to produce carboxymethyl starch. Among various organic solvents, using isopropanol as the solvent, the degree of substitution of carboxymethyl starch obtained is relatively high and the reaction efficiency is high. However, isopropanol has a high boiling point, is not easy to volatilize, and consumes a lot of energy. Moreover, isopropanol containing water is corrosive to a certain extent, which affects the life of the equipment. [0003] Methanol can dissolve sodium hydroxide and mix evenly with starch, which avoids side reactions of hydrolysis and increases the rate of etherification reaction, but methanol is toxic. [0004] Using ethanol as a solvent, the degree of substitution of carboxymethyl starch is relatively l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B31/12A61K47/36
Inventor 刘秋凤梁肖容王凯娜吴海茂
Owner DONGGUAN DONGMEI FOOD
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