Multi-concentration animal oral-nasal inhalation dynamic exposure equipment

Abstract

The invention discloses a multi-concentration animal oral-nasal inhalation dynamic exposure equipment which comprises an air compressor, an aerosol generation system, an oral-nasal exposure unit and a waste gas recovery treatment system, wherein the oral-nasal exposure unit comprises an experiment group exposure chamber; the aerosol generation system is connected with an aerosol inlet of the experiment group exposure chamber; a waste gas outlet of the experiment group exposure chamber is connected with the waste gas recovery treatment system; the equipment also comprises a multi-concentration dilution system; the experiment group exposure chamber comprises multiple sections of experiment exposure chambers; and the multi-concentration dilution system comprises a second aerosol diluter arranged among the sections of experiment exposure chambers and a third air flow controller for controlling the air inflow in the second aerosol diluter. The second aerosol diluter is arranged among the sections of experiment exposure chambers and used for diluting the aerosol entering the second section of experiment exposure chamber from the first section of experiment exposure chamber so as to meet the experiment requirements and perform experiment comparison in different concentration conditions.

Description

technical field [0001] The invention relates to the field of animal inhalation toxicology experiments, in particular to a multi-concentration animal oral and nasal inhalation dynamic exposure device. It can be used for the safety evaluation of inhalation toxicology drugs, the inhalation experiment research of acute toxicity of pesticides, the construction of various animal models of COPD and the experimental research of its drug efficacy, the research of the influence of air pollutants on the respiratory system of animals, etc. Background technique [0002] At present, in various scientific researches related to inhalation toxicology, especially the research on some substances harmful to human health, such as PM2.5, etc., because it cannot be tested directly or first on humans, experimental animals are often used for inhalation. exposure evaluation. Therefore, animal exposure devices have a wide range of applications in industry, agriculture, medicine, environmental polluti...

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Problems solved by technology

[0004] The purpose of the embodiments of the present invention is to provide a multi-concentration animal oral and nasal inhalation dynamic exposure equipment, which solves the problem in the prior art that animal inhalation toxicology experiments cannot be performed on the same experimental equipment and at multiple concentrations at the same time

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