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Method for constructing annular chitosan microgel

A technology of chitosan and microgel, which is applied in the field of building ring microgels, can solve the problems of lack of ring microgel construction methods, etc., and achieve the effects of excellent adsorption, good repeatability, and easy mass production

Inactive Publication Date: 2015-03-25
HARBIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the technical problems that the microgel prepared by the existing method is spherical and lacks the technical problem of the annular microgel construction method, and a method for constructing annular chitosan microgel is provided

Method used

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  • Method for constructing annular chitosan microgel
  • Method for constructing annular chitosan microgel
  • Method for constructing annular chitosan microgel

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specific Embodiment approach 1

[0016] Specific embodiment one: in the present embodiment, the method for constructing cyclic chitosan microgel is carried out according to the following steps:

[0017] 1. Set the molecular weight to 2×10 4 ~1×10 5 The chitosan is dissolved in an acid with a mass concentration of 0.5% to 2%, to obtain a chitosan solution with a mass concentration of 0.5% to 3%;

[0018] 2. Inject the chitosan solution into a container with a hole at the bottom, the inner diameter of the hole is 0.15-3.8 mm, and place a sodium tripolyphosphate coagulation solution with a molar concentration of 0.25-1 mol / L under the container with a hole at the bottom;

[0019] 3. The chitosan solution is dripped into the sodium tripolyphosphate coagulation solution at a dropping speed of 1.3-1.8m / s, and the chitosan solution is soaked in the sodium tripolyphosphate coagulation solution for 0.5-2 hours, and then centrifuged to obtain the ring chitosan microgels.

specific Embodiment approach 2

[0020] Embodiment 2: This embodiment is different from Embodiment 1 in that the acid described in step 1 is one of glacial acetic acid, acetic acid, hydrochloric acid and nitric acid or a mixture of several of them. Others are the same as in the first embodiment.

[0021] When the acid described in this embodiment is a mixture, the ratio between the respective components is arbitrary.

specific Embodiment approach 3

[0022] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the mass concentration of the chitosan solution in step 1 is 0.8% to 2.3%. Others are the same as those in the first or second embodiment.

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Abstract

The invention discloses a method for constructing annular chitosan microgel and relates to a method for constructing annular microgel. The annular microgel can be used as drugs, catalysts or other substance carriers. For solving the technical problems that the microgel prepared by using the existing method is spherical and the method for constructing the annular microgel is not available, the method comprises the following steps: step one: preparing a chitosan solution; step two: injecting the chitosan solution into a container with a hole at the bottom, putting a sodium tripolyphosphate solidification solution below the container with the hole at the bottom; step three: dropwise adding the chitosan solution in the sodium tripolyphosphate solidifying solution for soaking, centrifugally separating to obtain the microgel. The method for constructing the annular microgel or annular stent material provided by the invention is simple and easy to implement and good in repeatability, can be put into batch production easily. The method belongs to the preparation field of microgel.

Description

technical field [0001] The invention relates to a method for constructing ring-shaped microgel, which can be used as drug, catalyst or other substance carrier. Background technique [0002] Biomaterials are one of the key areas of development in the "Twelfth Five-Year Plan" and have significant social and economic benefits. The voids of the space network structure of the microgel system are filled with the liquid (up to 95%) as the dispersion medium, so the microenvironment is similar to the extracellular medium environment and has good biocompatibility, so that it is widely used in pharmaceuticals. , drug carriers, loadable cell scaffolds and other fields have a wide range of applications. [0003] The shape of the microgel not only determines its physical properties, but also directly regulates the release of its loaded drugs or the proliferation and differentiation of loaded cells. For example, the comparative areas of 1 volume of spherical microgel, cubic microgel, and...

Claims

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Application Information

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IPC IPC(8): C08J3/00C08L5/08
Inventor 王永亮韩志东李保强
Owner HARBIN UNIV OF SCI & TECH