Medicine composition for preventing and treating migraine disease, as well as preparation method and application thereof

A technology of migraine and medicine, which is applied in the field of combination of substances of traditional Chinese medicine with the effect of preventing and treating migraine, and in the field of combination of substances of Chinese medicine, which can solve the problems of unseen research reports on migraine disease.

Active Publication Date: 2015-04-01
石任兵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no related report on the purification and preparation of anti-migraine drug substance combination from Xiongshao Fang, and there is no related research report on the composition in the treatment of migraine diseases

Method used

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  • Medicine composition for preventing and treating migraine disease, as well as preparation method and application thereof
  • Medicine composition for preventing and treating migraine disease, as well as preparation method and application thereof
  • Medicine composition for preventing and treating migraine disease, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0031] Experimental Example 1: Anti-migraine effect of active components on rats with nitroglycerin-induced migraine model

[0032] 70 SD rats, half male and half male, were divided into 7 groups, 10 rats in each group, respectively blank group, model group, control group 1 (Zhengtian pill group), control group 2 (Tianshu capsule group), water extract group, alcohol extract group, alcohol preparation group. Replicate the nitroglycerin migraine model (10mg / kg), administer intragastrically immediately after modeling, take blood from the abdominal aorta immediately after 15min, centrifuge to obtain plasma, then take the brain, and measure the calcitonin gene-related phthalein content in the brain ( CPGR) (measured by ELISA method), content of endothelin (ET-1) (measured by ELISA method), and content of 5-hydroxytryptamine (5-HT) in plasma.

[0033] Experimental results: Comparison of 5-HT content in plasma and CGRP and ET-1 in brain of rats in each group

[0034]

[0035] No...

Embodiment 1

[0047] Embodiment 1: The preparation technology of Chinese medicinal material combination of prevention and treatment of migraine

[0048] Chuanxiong 333.4g White peony 333.3g Goat horn 333.3g

[0049] Take 0.6667 kg of Rhizoma Chuanxiong and Radix Paeoniae Alba according to the above ratio, 8 times the amount of 50% ethanol for reflux extraction twice, each extraction for 1 hour, and recover the solvent under reduced pressure to obtain the extract; add water to disperse and dissolve, so that the concentration of the aqueous solution is 0.05g / mL (Based on the amount of raw medicinal materials, the content of ferulic acid is 0.0180mg / ml, the content of chlorogenic acid is 0.0278mg / ml, the content of caffeic acid is 0.0010mg / ml, the content of chuanxionglide I is 0.0223mg / ml, and the content of chuanxionglide H content 0.0038mg / ml, paeoniflorin content 0.2283mg / ml), through 6.1L AB-8 macroporous adsorption resin, adsorption flow rate 2BV / h, resin column diameter-to-height ratio ...

Embodiment 2

[0056] Embodiment 2: preparation technology of traditional Chinese medicine drug substance combination for preventing and treating migraine

[0057] Chuanxiong 333.4g White peony 333.3g Goat horn 333.3g

[0058] Take 0.6667 kg of Rhizoma Chuanxiong and Radix Paeoniae Alba in accordance with the above ratio, 8 times the amount of 60% ethanol for reflux extraction once, and extract for 0.5 hours each time, recover the solvent under reduced pressure to obtain the extract; add water to disperse and dissolve, so that the concentration of the aqueous solution is 0.05g / mL (Based on the amount of raw medicinal materials, the content of ferulic acid is 0.0180mg / ml, the content of chlorogenic acid is 0.0278mg / ml, the content of caffeic acid is 0.0010mg / ml, the content of chuanxionglide I is 0.0223mg / ml, and the content of chuanxionglide H content 0.0038mg / ml, paeoniflorin content 0.2283mg / ml), through 6.1L AB-8 macroporous adsorption resin, adsorption flow rate 2BV / h, resin column diame...

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Abstract

The invention belongs to the field of researches and development of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating a migraine disease. The composition is prepared by screening a formula of ligusticum wallichii and radix paeoniae alba based on traditional Chinese medical clinical experience, wherein the formula is obtained by means of solvent extraction and macroporous resin purification and enrichment, and mainly comprises ingredients of amino acids, phenolic acids, phthalides, terpenes and alkaloids. Pharmacodynamic experiments prove that the medicine composition can be used for reducing the content of 5-HT in plasma of a rat model, reducing the content of related peptide of calcitonin genes and reducing the content of endothelin, so that the migraine can be prevented and treated.

Description

technical field [0001] The invention relates to a combination of Chinese medicinal substances, in particular to a combination of traditional Chinese medicinal substances capable of preventing and treating migraine, and a method for simultaneously preparing the combination. The invention belongs to the field of drug research and development. Background technique [0002] Migraine is a common clinical disease characterized by severe headache, left or right, and recurrent, frequently-occurring disease. Epidemiological survey shows that the incidence rate of migraine in my country is 985.2 / 100,000, and the annual incidence rate is 79.5 / 100,000. The incidence rate of the age group over 30 years old is increasing year by year, and the annual economic loss caused by it is as high as 130. At present, the exact pathophysiological mechanism of migraine is still not very clear in western medicine, although some western medicines such as serotonin receptor agonists, ergotamines, non-ster...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P25/06A61K35/32
CPCA23L2/38A23V2002/00A61K35/32A61K36/236A61K36/65A61K36/71A61K2236/33A61K2236/333A61K2300/00A23V2200/322A23V2250/21
Inventor 石任兵王庆国王永炎迟蕾彭平姜艳艳孙雅姝左胜杨书娟
Owner 石任兵
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